Fragrance material review on cinnamaldehyde

Cocchiara, J.; Letizia, C.S.; Lalko, J.; Lapczynski, A.; Api, A.M.

doi:10.1016/j.fct.2004.09.014

Cited by 115 publications

(84 citation statements)

References 185 publications

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“…It has been used as an anticancer agent (Nagle et al, 2012), an insecticide (Cheng et al, 2009), a fungicide (Bang et al, 2000;Shreaz et al, 2011), and a bactericide (Nostro et al, 2012). It is also used commercially as an additive in many foods and in fragrances (Cocchiara et al, 2005). The dental literature has reports of adverse reactions to CAD, and one case report links heavy use of cinnamon-flavored gum to the development of squamous cell carcinoma on the tongue (Westra et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Behar

Davis

Wang

et al. 2014

Toxicology in Vitro

218

211

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a b s t r a c tIn a prior study on electronic cigarette (EC) refill fluids, Cinnamon Ceylon was the most cytotoxic of 36 products tested. The purpose of the current study was to determine if high cytotoxicity is a general feature of cinnamon-flavored EC refill fluids and to identify the toxicant(s) in Cinnamon Ceylon. Eight cinnamon-flavored refill fluids, which were screened using the MTT assay, varied in their cytotoxicity with most being cytotoxic. Human embryonic stem cells were generally more sensitive than human adult pulmonary fibroblasts. Most products were highly volatile and produced vapors that impaired survival of cells in adjacent wells. Cinnamaldehyde (CAD), 2-methoxycinnamaldehyde (2MOCA), dipropylene glycol, and vanillin were identified in the cinnamon-flavored refill fluids using gas chromatography-mass spectrometry and high-pressure liquid chromatography (HPLC). When authentic standards of each chemical were tested using the MTT assay, only CAD and 2MOCA were highly cytotoxic. The amount of each chemical in the refill fluids was quantified using HPLC, and cytotoxicity correlated with the amount of CAD/ product. Duplicate bottles of the same product were similar, but varied in their concentrations of 2MOCA. These data show that the cinnamon flavorings in refill fluids are linked to cytotoxicity, which could adversely affect EC users.

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Section: Discussionmentioning

confidence: 99%

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Behar

Davis

Wang

et al. 2014

Toxicology in Vitro

218

211

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“…15 Cinnamaldehyde for example is both a food and perfume additive, 1 conferring the flavour and aroma of cinnamon, and also serves as an insect repellent. 2 Such aldehydes are typically derived by selective oxidation of their corresponding allylic alcohols.…”

Section: Introductionmentioning

confidence: 99%

Tunable Pt nanocatalysts for the aerobic selox of cinnamyl alcohol

et al. 2013

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The selective aerobic oxidation of cinnamyl alcohol over Pt nanoparticles has been tuning via the use of 5 mesoporous silica supports to control their dispersion and oxidation state. High area two-dimensional SBA-15, and three-dimensional, interconnected KIT-6 silica significantly enhance Pt dispersion, and thus surface PtO 2 concentration, over that achievable via commercial low surface area silica. Selective oxidation activity scales with Pt dispersion in the order KIT-6 ≥ SBA-15 > SiO 2 , evidencing surface PtO 2 as the active site for cinnamyl alcohol selox to cinnamaldehyde. Kinetic mapping has quantified key 10 reaction pathways, and the importance of high O 2 partial pressures for cinnamaldehyde production.

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“…The skin irritation relating cinnamaldehyde at high dosages has been reported by Cocchiara et al, 2005 based on experiments in animal models of mice, gunea pigs, and rabbits. Other essential oil from plant, for example, tea tree oil induced membranetoxicity owing to the presence of monoterpenoid components 10 .…”

Section: Ijpsr (2017) Volume 8 Issue 8 (Review Article)mentioning

confidence: 99%

“…Typically, essential oils are highly complex mixtures of often hundreds of individual aroma compounds 5 . Toxicity of Essential Oils: Cinnamaldehyde is considered to have low toxicity, yet reported to cause skin irritation to humans 9 . Other conceivable toxin found in the bark of cinnamon is coumarins which cause poisonous effect as compared to that of cinnamaldehyde.…”

Section: Ijpsr (2017) Volume 8 Issue 8 (Review Article)mentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:Eessential oils are known to possess antimicrobial activity. This review article explains the antimicrobial reaction, application, effects, and characteristics of cinnamaldehyde. Amongst the different essential oils, Cinnamaldehyde is observed to be the most effective antimicrobial agent. The current studies on cinnamaldehyde in the field of microbiology have been highlighted. This review explains the different methods, those are used for antimicrobial evaluation. Additionally, the anti-physiologic effect of antimicrobial agents using microbial respiration rate is also discussed.

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Fragrance material review on cinnamaldehyde

Cited by 115 publications

References 185 publications

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Tunable Pt nanocatalysts for the aerobic selox of cinnamyl alcohol

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