Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces

Boateng, Joshua; Auffret, Anthony D.; Matthews, Kerr H.; Humphrey, Michael; Stevens, H. N. E.; Eccleston, Gillian M.

doi:10.1016/j.ijpharm.2010.01.008

Cited by 112 publications

(69 citation statements)

References 18 publications

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“…However, excess of plasticiser could result in higher free volume between polymers that are highly slippery and difficult to handle (very sticky) as shown in mechanical properties and SEM images of BK HPMC films obtained from polymeric solution with GLY above 2% w/v. Therefore a balance between flexibility and toughness with an optimum elongation ideally between 30-50% is desirable [28].…”

Section: Discussionmentioning

confidence: 99%

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Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

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Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations were characterised using texture analyser (tensile and hardness, mucoadhesion), scanning electron microscopy, x-ray diffractometry, attenuated total reflection -Fourier transform infrared (ATR-FTIR), differential scanning calorimetry (DSC) and swelling capacity. Drug loaded films and wafers were characterised for content uniformity (HPLC) whilst the drug loaded wafers only were further characterised for in vitro drug dissolution. SA modified and improved the functional properties of HPMC at optimum ratio of HPMC: SA of 1.25 : 0.75. Generally, both films and wafers (blank and drug loaded) were amorphous in nature which impacted on swelling and mucoadhesive performance.HPMC-SA composite wafers showed a porous internal morphology with higher mucoadhesion, swelling index and drug loading capacity compared to the HPMC-SA composite films which were non-porous. The study demonstrates the potential use of composite HPMC-SA wafers in the buccal delivery nicotine.

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Section: Discussionmentioning

confidence: 99%

“…Films are usually prepared by solvent evaporation method [9,10] while wafers are prepared by a sublimation process known as freeze-drying [11]. There has been research reported on the delivery of NIC via the buccal route using films [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Okeke

Boateng

2016

International Journal of Biological Macromolecules

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“…It was observed that the wafers had a higher mucoadhesion capacity compared to the films. Since wafers are porous in nature, they hydrate more quickly in the presence of mucin solution and form strong hydrogen bonding more quickly with the protein 42 . POL-CAR-BLK wafers showed the highest stickiness values (3.12±0.4 N) and lowest cohesiveness (2.48±0.3mm).…”

Section: Mucoadhesion Studies By Texture Analysis In the Presence Of mentioning

confidence: 99%

“…Among the blank formulations, POL-CAR-BLK film showed slower diffusion of the mucin while the corresponding POL-CAR-BLK wafer showed a wavy diffusion profile which may be associated with the porous nature of the wafers which caused unequal distribution of mucin through these pore channels. Previously, Boateng and co-workers reported that wafers have the capacity to hydrate more quickly than their corresponding films 42 . The same trend was observed when comparing POL-SA-BLK film and wafer whilst diffusion was faster overall for both POL-SA-BLK films and wafers compared to their corresponding CAR containing formulations respectively.…”

Section: Comparison Of Blank Films and Wafersmentioning

confidence: 99%

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

Boateng

Pawar

2015

RSC Adv.

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The adhesive properties of two dressing types, solvent cast films and freeze-dried wafers have been determined and compared using two analytical techniques, combined with chemometrics data analysis. Films and wafers were prepared from gels containing polyox (POL) combined with carrageenan (CAR) or sodium alginate (SA), glycerol (GLY) as plasticiser (films) with streptomycin and diclofenac as model drugs. The gels were dried in an oven at 40°C or freeze-dried to obtain films and wafers respectively. The adhesive performance of the films and wafers was assessed with 6.67% w/v gel using a texture analyser to measure the stickiness, work of adhesion and cohesiveness. The effect of viscosity of simulated wound fluid[(containing (2% w/w or 5% w/w bovine serum albumin)] and mucin solution (2% w/w) present on the gelatin surface on texture analyser profiles was investigated. Furthermore, the adhesive properties were estimated and evaluated using attenuated total reflectance Fourier transform infrared spectroscopy by monitoring the diffusion of mucin solution [2% w/w in phosphate buffered saline (PBS) pH 7.4] through the formulations. The diffusion data was analysed using target factor analysis (chemometrics approach) to establish proof of concept for predicting adhesion by measuring mucin interaction and its diffusion through films and wafers. There was a significant effect of simulated wound fluid, viscosity, plasticizer (for films) and drug loading on the adhesive performance of both films and wafers. POL-SA films showed higher mucoadhesive performance in the presence of viscous simulated wound fluid containing 5% bovine serum albumin. Wafers and plasticised films demonstrated high detachment force indicating strong interactions between the chains of the polymers (POL, SA and CAR) and the model wound surface (gelatin). ATR-FTIR spectroscopy showed that mucin diffused independently through the solvent and across the films and wafers. POL-CAR films generally showed slower diffusion of mucin when compared with POL-SA films whilst the opposite effect was observed for diffusion through POL-CAR wafers and POL-SA wafers. Generally, diffusion through wafers was faster than the corresponding films.

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“…Hot-melt extrusion [35][36][37] In hot-melt extrusion, A blend of pharmaceutical ingredients is molten.…”

Section: 92mentioning

confidence: 99%

A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System

Dave

Mishra

2017

Curr. Res. Pharm. Sci.

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Bioadhesive drug delivery system has gained sufficient attention of researchers not only due to their enormous advantages but also feasibility of formulation and patient compliance. In this review an effort was made to describe aspects of bioadhesive films, their preparation methods, polymer used in the formulation of this type of drug delivery system, different mechanism of how plasticizer work in drug delivery films and different evaluation parameters of this type of formulation so that this can be further studied and formulated with wide spectrum drug by checking suitability of the formulation with the active pharmaceutical ingredient.

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Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces

Cited by 112 publications

References 18 publications

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy

Evaluation of in vitro wound adhesion characteristics of composite film and wafer based dressings using texture analysis and FTIR spectroscopy: a chemometrics factor analysis approach

A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System

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