Chapter 5 The Pharmacology and Toxicology of the Papaveraceae Alkaloids

Preininger, V.

doi:10.1016/s1876-0813(08)60277-8

Cited by 18 publications

(6 citation statements)

References 241 publications

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“…6,8 Anti-arrhythmic effects have been also demonstrated for AL. 6,8 Anti-arrhythmic effects have been also demonstrated for AL.…”

Section: Effects On Cardiovascular System and Relaxant Effects On Smomentioning

confidence: 99%

“…The protopine alkaloids are synthesized in plants from ubiquitous L-tyrosine via the (S)-reticulin pathway 1 as protection against biotic stressors. 6 Currently, research on PR and AL is focused on elucidating the molecular biological mechanisms of action, discovery of further biological activities, and their applications as active constituents in human and veterinary phytopreparations. 2,3 However, systematic research on protopine alkaloids began in the sixties of the last century when the structure of the main protopines was clearly identified.…”

Section: Introductionmentioning

confidence: 99%

“…The first finding of protopine (PR) and allocryptopine (AL) in plants was reported by Hesse and Selle at the end of the 19 th century. The chemical and selected pharmacological properties of these alkaloids were reviewed by Guinaudeau, 7 Preininger, 6 Onda and Takahashi. 4,5 During the last quarter of the 20 th century, new methods for the analysis of both alkaloids in biological material were developed and their biological activities, toxicological parameters and biotransformation pathways were reported.…”

Section: Introductionmentioning

confidence: 99%

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The Chemical and Biological Properties of Protopine and Allocryptopine

Vacek¹,

Walterová²,

Vrublová³

et al. 2010

HETEROCYCLES

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“…6,8 Anti-arrhythmic effects have been also demonstrated for AL. 6,8 Anti-arrhythmic effects have been also demonstrated for AL.…”

Section: Effects On Cardiovascular System and Relaxant Effects On Smomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Chemical and Biological Properties of Protopine and Allocryptopine

Vacek¹,

Walterová²,

Vrublová³

et al. 2010

HETEROCYCLES

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“…Possui ação antimicrobiana (Pizzorno;Murray, 1985). Mostrou-se efi caz no tratamento de diarréias causadas por enterotoxinas, como Vibrio cholerae e Escherichia coli (Preininger, 1975). Tradicionalmente a raiz é usada para o tratamento de litíase biliar (Bruneton, 1991).…”

Section: A Robusterinaunclassified

Desenvolvimento e validação de metodologia para quantificação de alcalóides totais como berberina em fitoterápico contendo Berberis vulgaris L.

Oliveira¹,

Albuquerque²,

Xavier³

et al. 2006

Rev. bras. farmacogn.

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Unitermos: Robusterina® , fi toterápico, validação, alcalóides, doseamento.ABSTRACT: "Development and validation of a method for the quantifi cation of total alkaloids as berberine in an herbal medicine containing Berberis vulgaris L.". Robusterina ® is a herbal medicine, with effectiveness in the treatment of menstrual cycle disfunctions. Its composition includes Berberis vulgaris L., with sedative and antispasmodic action; Gossypium herbaceum L., with emmenagogue, hemostatic and ocitocic action; Viburnum opulus L., with antispasmodic action for the treatment of menstrual colics. In accordance with Resolution RDC N° 48, of 16 of March of 2004 (ANVISA, Brazil) the product meets the defi nition of "Fitoterápico" (phytotherapeutic agent). The presence of alkaloids in Berberis vulgaris and the absence of analytical methodologies for quantifi cation of the product, stimulated us to develop and validate a method in accordance with Resolution RE N° 899, of 29 of May of 2003. Such methodology is based on the determination of alkaloids using a spectrophotometric method, with Dragendorff as a precipitating reagent, and using berberine sulphate, as a standard. The calibration curve was determined with six concentrations ranging between 40 and 200 μg/mL. The equation of the calibration curve is y = 0.0038x + 0.0092 with R 2 of 0.9996. The parameters robustness, precision, specifi city, limit of detection and quantifi cation and accuracy have been evaluated using 95% confi dence interval (test t of Student, ANOVA). Keywords: Robusterina® , herbal medicine, validation, alkaloids, quantifi cation. INTRODUÇÃOA Robusterina ® é um medicamento (solução oral) de origem exclusivamente vegetal. Encontra-se no mercado nacional desde 1932, sendo utilizada no tratamento das disfunções e regulação do ciclo menstrual e, por estimular a contração uterina, seu uso é contraindicado no período gestacional. A dose média diária é de uma colher de sopa (15 mL) 3 vezes ao dia. O tratamento deve ser suspenso quando houver normalização do ciclo menstrual, ou no caso de gravidez. Apresenta-se em sua constituição três plantas: Berberis vulgaris, Gossypium herbaceum e Viburnum opulus.Para o estudo, foi dada ênfase a Berberis vulgaris, pois é a única planta que apresenta na sua constituição alcalóides, para a qual foi desenvolvida 358 Desenvolvimento e validação de metodologia para quantifi cação de alcalóides totais como berberina em fi toterápico contendo Berberis vulgaris L.

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“…Argemonr mexiccznci Linn (family Papaveraceae) is a wild plant whose seeds have superficial resemblance to the dark-coloured mustard seeds. Accidental or deliberate contamination of edible oils with argemone oil and consumption of such adulterated oils even for a short duration gives rise to a toxicity syndrome commonly referred to as epidemic dropsy [Hakim et al, 1961;Krishnamachari and Satyanarayana, 1972;Preininger, 1975;Khanna and Singh, 1983;Mohan et al, 1984;Kumar et al, 19921. The principal constituents responsible for the toxicity of argemone oil have been identified as the benzophenanthridine alkaloids, sanguinarine and dihydrosanguinarine ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: Role of Na⁺, K⁺‐ATPase

1993

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The effect of the argemone alkaloid, sanguinarine, was studied on the active transport of D-glucose and some of the L-amino acids in everted sacs of the small intestine of rats. Sanguinarine (1.0 mumole) was found to inhibit (61%) the transport of D-glucose, while an alkaloid concentration of 0.1 mumole was ineffective. Both 0.1 and 1.0 mumole of sanguinarine had no effect on the transport of the L-amino acids including aspartic acid, lysine, and tyrosine. Sanguinarine showed a dose dependent inhibition of intestinal and hepatic Na+,K(+)-ATPase in a non-competitive manner. The inhibition of Na+,K(+)-ATPase by sanguinarine may in turn inhibit the active transport of D-glucose which requires a sodium pump.

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Chapter 5 The Pharmacology and Toxicology of the Papaveraceae Alkaloids

Cited by 18 publications

References 241 publications

The Chemical and Biological Properties of Protopine and Allocryptopine

The Chemical and Biological Properties of Protopine and Allocryptopine

Desenvolvimento e validação de metodologia para quantificação de alcalóides totais como berberina em fitoterápico contendo Berberis vulgaris L.

Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: Role of Na⁺, K⁺‐ATPase

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Chapter 5 The Pharmacology and Toxicology of the Papaveraceae Alkaloids

Cited by 18 publications

References 241 publications

The Chemical and Biological Properties of Protopine and Allocryptopine

The Chemical and Biological Properties of Protopine and Allocryptopine

Desenvolvimento e validação de metodologia para quantificação de alcalóides totais como berberina em fitoterápico contendo Berberis vulgaris L.

Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: Role of Na+, K+‐ATPase

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Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: Role of Na⁺, K⁺‐ATPase