Chapter 3 Noniridoid Bisindole Alkaloids

Sápi, János; Massiot, Georges

doi:10.1016/s0099-9598(08)60155-8

Cited by 5 publications

(2 citation statements)

References 132 publications

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“…An extensive variety of indole alkaloids have been isolated from marine organisms. − In our investigations into the chemistry of marine organisms, we have isolated a variety of simple indole alkaloids from a marine sponge, including a symmetrical bisindole alkaloid. We report here the isolation and structural elucidation of the symmetrical bisindole dimer 1,2-bis(1 H -indol-3-yl)ethane-1,2-dione ( 1 ) from the marine sponge Smenospongia sp (Thorectidae).…”

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confidence: 99%

1,2-Bis(1H-indol-3-yl)ethane-1,2-dione, an Indole Alkaloid from the Marine Sponge Smenospongia sp.

et al. 2002

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confidence: 99%

1,2-Bis(1H-indol-3-yl)ethane-1,2-dione, an Indole Alkaloid from the Marine Sponge Smenospongia sp.

et al. 2002

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“…Today, over 100 microbial products continue to be used clinically as antibiotics and anti-tumor agents. 4 A large variety of indole alkaloids have been isolated from marine organisms, [5][6][7][8][9][10] among which is the marine Streptomycete. [11][12][13][14] Terrestrial Streptomyctes was also investigated for its antibiotic contents.…”

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confidence: 99%

Biotransformation of Indole Alkaloid by Terrestrial Streptomyces Gw 14/587 Strain Into a Selective Phycotoxic Agent

Haggag

Laatsch

2004

Bulletin of Pharmaceutical Sciences. Assiut

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Methyl indole was isolated as a metabolite from the culture broth of terrestrial Streptomyces GW 14/587 strain which was fed with indole after two days growth and then inoculated for another two, three and four days to optimize the experiment condition for highest metabolite concentration. The structure of the isolated methyl indole was established using spectral techniques of HPLC-MS, EI-MS, 1 H and 13 CNMR. Also the bacterial extract showed a high selective phycotoxic activity against Scendensmus subspicatus among the different tested microalgae, yeast, fungi and bacteria.

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Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus

Zhang

Tian

et al. 2013

Natural Product Research

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Two new vinblastine-type N-oxide alkaloids, 17-desacetoxyvinblastine N'b-oxide (1) and 20'-deoxyvinblastine N'b-oxide (2), were isolated from the leaves of Catharanthus roseus. The structures of 1 and 2 were established by the analysis of their nuclear magnetic resonance and HR-ESI-MS spectroscopic data. All alkaloids were evaluated for their cytotoxic activities against the human hepatocellular carcinoma (HepG2) cell line, human colorectal carcinoma (Lovo) cell line and human breast carcinoma (MCF-7) cell line by the MTT method in vitro, respectively. The results showed that cytotoxic activities of alkaloids 1 and 2 exhibited moderate inhibitory activity on the proliferation of three cancer cells.

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Chapter 3 Noniridoid Bisindole Alkaloids

Cited by 5 publications

References 132 publications

1,2-Bis(1H-indol-3-yl)ethane-1,2-dione, an Indole Alkaloid from the Marine Sponge Smenospongia sp.

1,2-Bis(1H-indol-3-yl)ethane-1,2-dione, an Indole Alkaloid from the Marine Sponge Smenospongia sp.

Biotransformation of Indole Alkaloid by Terrestrial Streptomyces Gw 14/587 Strain Into a Selective Phycotoxic Agent

Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus

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