Two new vinblastine-type <i>N</i>-oxide alkaloids from <i>Catharanthus roseus</i>

Zhang, Wei-Ku; Xu, Jiaming; Tian, Hai‐Yan; Wang, Lei; Zhang, Xiaoqi; Xiao, Xu-Zhi; Li, Ping; Ye, Wen‐Cai

doi:10.1080/14786419.2013.790029

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…This is one of the most precious anticancer plants indigenous to Madagascar. Previously, approximately 30 bis-indole alkaloids and over 60 monomeric indole alkaloids have been isolated from the aerial parts and roots of C. roseus [ 85 , 86 ]. Wang et al [ 87 ] isolated three new cytotoxic dimeric indole alkaloids ( 32 – 34 ) along with other five known compounds from the whole plant of C. roseus collected from China ( Table 4 ).…”

Section: Phytochemistry Of Ethiopian Anticancer Plantsmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.

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Section: Phytochemistry Of Ethiopian Anticancer Plantsmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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“…Therefore, the employment of phytochemicals as complementary or first-line treatments for cancer came as a recurring alternative over the years [7,8]. Actually, different plantderived medicines are currently employed in chemotherapy medication for different cancer treatments, such as the alkaloids vincristine and vinblastine, originally obtained from Catharanthus roseus, being used in the treatment of acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer, bladder cancer, brain cancer, and testicular cancer, among others [9]. Paclitaxel, obtained from Taxus brevifolia, is used to treat breast, ovarian, lung, bladder, prostate, as well as other types of solid tumor cancers [10].…”

Section: Introductionmentioning

confidence: 99%

Quercetin-Rich Extracts from Onions (Allium cepa) Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties

Veiga¹,

Irioda²,

Mogharbel³

et al. 2022

Pharmaceuticals

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Adrenocortical carcinoma (ACC) is a rare subtype of cancer, with a poor prognosis in children and adults. Mitotane is the only approved adrenolytic drug for the treatment of ACC, which has controversies regarding its efficacy and side effects on patients. Onion (Allium cepa), a worldwide consumed food, is associated with many health benefits. Along with its glycosides, the flavonoid quercetin is abundant in onions. After evaluating the cytotoxicity of A. cepa extracts on adrenocortical carcinoma cell line (H295R), the rich quercetin fractions had better results. Then, we aimed to compare the quercetin vs. mitotane effectiveness, using adrenocortical carcinoma cell lines H295R and SW-13. Quercetin showed a higher cytotoxicity response on both cancerous cell lines after 10 µM concentration, while mitotane only after 30 µM. Cell cycle dynamics were altered upon quercetin treatments, with G2 phase increase with 30 µM of quercetin on H295R cell line and G1 arrest on SW-13 cell line with 15 µM. Early and late apoptosis, alongside intracellular calcium, were increased on SW-13 treated with 30 µM of quercetin, and ROS rates were reduced by quercetin on H295R. Therefore, quercetin-rich onions have the potential to be a natural source of anticancer agents for adrenocortical carcinoma.

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“…Most of the alkaloids isolated in the previous years from this plant were reported by Heijden et al, (2004) [194] . With the introduction of the HR-EI-MS technique, a greater number of new alkaloids have been reported in the past few years (Wang et al, 2011;Zhang et al, 2013) [206,116] . Recently, Zhang et al, (2013) [116] [204] isolated Catharoseumine from the whole plant at the concentration of 0.786 mg/kg.14', 15'didehydrocyclovinblastine, 17-deacetoxyvinamidine and 17deacetoxycyclovinblastine was also isolated by Wang et al…”

Section: Alkaloidsmentioning

confidence: 99%

A review on phytochemical constituents and pharmacological properties of Catharanthus roseus (L.) G. Don

Sharma,

Singla,

Kaur

et al. 2024

J. Med. Plants Stud.

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Ethnopharmacological relevance: Catharanthus roseus (also called Sadabahar in India), is utilized as a common traditional medicine in India, England, Thailand, Japan and Australia. It was traditionally used to treat wasp string, gonorrhoea, hypertension and menstrual cycle. Various compounds obtained from this plant are utilizeds for medicinal purposes. It is even commercially formulated for its anticancer properties. Aims: This review aims to provide a systematic summary of Catharanthus roseus and to reveal the correlation between the traditional uses and pharmacological activities so as to offer inspiration for future research. Materials and methods: All corresponding information about Catharanthus roseus was collected using Google Scholar and from various scientific databases including Springer, Science Direct, Wiley, and PubMed. Local dissertations and books were searched as well. Results: According to classical ayurvedic text, Catharanthus roseus dominantly displays antidiabetic effect in diabetes mellitus person and its hypertension properties which were verified in modern medicine for their use. In modern research, more than 200 compounds were identified from Catharanthus roseus. Leaves contain large number of alkaloids along with flavonoids, sterols, saponins, amino acid, polyphenols and anthocyanins. Alkaloids such as vindoline, vincristine, vinblastine, and catharanthine, are considered as the characteristic and active constituents of this plant. They exhibited anticancer, antidiabetic, antivirus, antibacterial effects, etc. Vinblastine and vincristine acts on the cancer cells by disrupting the mitotic spindle fibres thereby inhibiting cell division. Currently, there is no lethal effect of Catharanthus roseus at lower dosage on human i.e., less than 5000 mg/kg. Conclusions: Due to pantropical distribution of C. roseus, it has wide range of traditional uses in different countries. Among these uses antitumor, anticancer and antidiabetic potentialswere further supported by scientific research and clinical trials to develop commercial medicine. For future research, still other traditional uses are yet to be authenticated so more in vivo experiments and clinical studies are encouraged to further clarify the relation between these traditional uses and their modern applications.

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Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus

Cited by 15 publications

References 13 publications

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Quercetin-Rich Extracts from Onions (Allium cepa) Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties

A review on phytochemical constituents and pharmacological properties of Catharanthus roseus (L.) G. Don

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