Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report

Abstract

Adenocarcinoma and adenosquamous carcinoma (AS) are 2 rare histological types of cervix uteri cancer constituting almost 20% of all cervix cancers, leading to a lack in patient management guidelines. We report the case of a 32-year-old woman with an oligometastatic cervix AS for which a multimodal treatment approach was used. Despite the patient’s bad prognosis, a complete response was achieved, which further resulted in excellent local control and prolonged survival. This case report serves the purpose of encouraging multidisciplinary team work and out-of-the-box thinking that should result in an individualized treatment for rare cancer subtypes.

Radiation response of soft‐tissue extramedullary plasmacytoma in multiple myeloma—A case report

“…As for the treatment of EMP, a local approach is considered the most suitable and with increased chances of success rate. Unlike in other radioresistant tumors (eg, cervix uteri, colorectal) 15,16 that showed unpredictable radiation response, for plasmacytoma previously published data showed a more favorable outcome even at lower radiation doses. Therefore, surgery or local radiotherapy have been associated with encouraging results in previously published studies 17 leading to high 10 years local control (>70%) and OS (>50%) survival rates.…”

Distribution of Human Papilloma Virus (HPV) in Cervical Adenocarcinoma and Adenosquamous Carcinoma

“…The incidence of cervical adenocarcinoma and other type epithelial cancer, including adenosquamous carcinoma, was approximately 20-30% of cervical cancer. Both are rarely found so that guidelines in the management of therapy have not been established yet (Molijn et al 2016, Georgescu et al 2020. However, the incidence of cervical adenocarcinoma tends to increase, including in 13 European countries (Bray et al 2005), as well as in the Netherlands (Horst et al 2017).…”

“…The remaining is cervical adenocarcinoma and adenosquamous carcinoma that around 20 -25% of cervical cancer (Fujiwara et al 2014, Siriaunkgul et al 2013. In the last decades, the incidence of squamous cell carcinoma tends to decrease, but adenocarcinoma and adenosquamous carcinoma tend to increase (Gien et al 2010, Zhang et al 2020. Recently, both adenocarcinoma and adenosquamous carcinoma is still treated in the same way as squamous cell carcinoma, although it has a different microscopic appearance.…”

“…Both of adenocarcinoma or adenosquamous carcinoma are located deeper than the ectocervix (Stolnicu et al 2018, Kurman et al 2011. Some studies showed that the prognosis of adenocarcinoma and adenosquamous carcinoma is worse than squamous cell carcinoma (Gien et al 2010, Fujiwara et al 2014, so that early detection and histopathological diagnosis are important to use as the basis for determining the management of this cancer therapy.…”

How COVID-19 Pandemics Changed the Treatment Protocols for Patients with Gynecological Tumors

“…Monogenic diabetes (MD) c a single gene is a separate form etiology, clinical presentation, ther nogenic diabetes is a heterogenous diabetes caused by mutations in diff genes that are pivotal for pancreas of the level of glucose for insulin tabolism, cell membrane depolariza synthesis/excretion [13][14][15][16][17][18][19]. Mon common, but it does account for diabetes cases [20].…”