Changes of Left Atrial Phasic Function Assessed by Speckle Tracking Echocardiography in Untreated Hypertension

Abstract

KEY WORDShypertension, left atrium, speckle tracking echocardiography, strain, strain rate Changes in the three phases of left atrial (LA) function have not been well studied in hypertension. We studied phasic function of LA by speckle tracking echocardiography (STE) in hypertension. Sixty-one consecutive untreated hypertension patients and 32 sex-and age-matched healthy participants were included. Two-dimensional (2D) images obtained from apical four-chamber and two-chamber views were used for STE analysis of LA. LA peak positive strain (39.8 AE 10.9 vs. 45.3 AE 12.7 %, p Z 0.031), peak negative strain (À2.2 AE 1.5 vs. À3.0 AE 1.9 %, p Z 0.029), and conduit strain rate (À2.0 AE 0.5 vs. À2.4 AE 0.6 1/s, p Z 0.005) were significantly decreased in hypertension. Twenty hypertensive patients (32%) had diastolic dysfunction. Positive strain (34.8 AE 7.2 vs. 42.2 AE 11.6 %, p Z 0.012) and conduit strain rate (À1.7 AE 0.4 vs. À2.2 AE 0.5 1/ s, p < 0.001) were decreased in patients with diastolic dysfunction. Only conduit strain rate was independently associated with diastolic dysfunction (OR 11.9, p Z 0.026) after multivariable analysis. LA phasic function is decreased in untreated hypertension. Decreased LA conduit function is associated with diastolic dysfunction in hypertension. ª

Echocardiographic parameters versus CHA2DS2-VASc score in prediction of overall cardiac events, heart failure, and stroke in non-valvular atrial fibrillation

“…The method for LA deformation analysis by speckle tracking echocardiography has been described in detail in our previous studies [14,15]. In patients with AF, we analyzed only the peak systolic positive strain (LAe R ) and strain rate (LASR R ) during LA filling (reservoir phase), and the peak negative conduit strain rate (LASR CD ) in LV early filling while discarding the contractile strain and strain rate (peak negative strain and strain rate after the P-wave) [14].…”

Predictive Value of Left Atrial Deformation on Prognosis in Severe Primary Mitral Regurgitation

“…16 The method for LA deformation analysis by STE was described in detail in our previous studies. 13,14 The endocardial border of the left atrium was manually deflned using a point-and-click technique. Epicardial surface tracing was automatically generated by the system, creating a region of interest that was manually adjusted to cover the full thickness of the myocardium in the systolic frame.…”

ARTERIAL HYPERTENSION IN THE PRESENCE OF OVERWEIGHT AND OBESITY. THE CAPABILITIES OF AMLODIPINE AND LISINOPRIL COMBINATION. Part 2. Antihypertensive and Organoprotective Effects of Amlodipine/Lisinopril Fixed-Dose Combination in Patients with Arterial Hypertension in the Presence of Overweight and Obesity

“…Сни-жение деформационных способностей ЛЖ у больных с ГБ является фактором риска ХСН, впервые возник-шей стенокардии, внезапной сердечной смерти, МИ [52]. Ремоделирование левого предсердия (ЛП) и его дилатация наблюдаются уже на ранних стадиях АГ и ассоциируются с риском развития фибрилляции пред-сердий, а также МИ [53]. Таким образом, на сего-дняшний день изменения упруго-эластических свойств миокарда ЛЖ и левого ЛП представляют собой новые факторы риска у пациентов с АГ.…”