ARTERIAL HYPERTENSION IN THE PRESENCE OF OVERWEIGHT AND OBESITY. THE CAPABILITIES OF AMLODIPINE AND LISINOPRIL COMBINATION. Part 2. Antihypertensive and Organoprotective Effects of Amlodipine/Lisinopril Fixed-Dose Combination in Patients with Arterial Hypertension in the Presence of Overweight and Obesity

Остроумова, О Д; Кочетков, А. И.; Kopchjonov, I. I.; Fomina, V. M.

doi:10.20996/1819-6446-2017-13-6-841-850

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…Целесообразность совместного применения амлодипина и лизиноприла при АГ (в том числе у пациентов с ишемической болезнью сердца (ИБС), СД и заболеваниями почек) подробно описаны в целом ряде публикаций [10,12,13,14,15,21]. В нескольких клинических исследованиях было установлено, что комбинированная терапия амлодипином и лизиноприлом, в виде отдельных таблетированных препаратов и в индивидуально подобранных дозах, оказывает выраженный гипотензивный эффект и отличается хорошей переносимостью у больных АГ II и III степени с поражением органов-мишеней (ПОМ) и ассоциированными клиническими состояниями (АКС), а также уменьшает диастолическую дисфункцию левого желудочка (ЛЖ) у пациентов с АГ и снижает альбуминурию у лиц с СД 2-го типа и диабетической нефропатией [16,17,18].…”

Section: оригинальные исследованияunclassified

The optimal combination of Lysinopril and Amlodipine for the treatment of patients with hypertension

Джунусбекова

Tundybayeva²,

Leonovich

et al. 2020

Medicine

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Arterial hypertension (AH) remains one of the most common diseases in the world. Reducing cardiovascular risk of mortality from cardiovascular complications is a priority in the treatment of hypertension. Targets of hypertension therapy is to achieve SBP/DBP <140/80 mm Hg. article, regardless of cardiovascular risk and comorbidity. The choice of antihypertensive therapy depends on blood pressure levels, the presence or absence of concomitant diseases, lesion of target organs. Effective and long-lasting control of AH proved by the use of combinations of antihypertensive drugs, including antagonists and ACE inhibitors. The purpose of the study. Evaluation of clinical efficacy and safety of fixed combination antihypertensive therapy using lisinopril combined with amlodipine in patients with hypertension. Material and methods. The study included 30 respondents from essential hypertension II-III degree (ESH/ESC, 2018) aged 35 to 75 years. Patients were treated with the schema a (lisinopril 10 mg, amlodipine 5 mg) and scheme b (lisinopril 20 mg, amlodipine 10 mg) fixed combination therapy with the drug VivaCor® once in the morning. The period of observation was 3 months. At the time of inclusion and at the end of the study all respondents was performed echocardiography, daily monitoring of blood pressure, evaluation of laboratory and instrumental methods of research. Results and discussion. The combination of lisinopril with amlodipine has a fairly high antihypertensive activity, provides a significant cardioprotective effect and is an integral part of antihypertensive therapy in the long-term strategy of administering patients with high hypertensive / very high total cardiovascular risk. Conclusions: 1. The use of a fixed combination of lisinopril and amlodipine in patients with hypertension instead of free or other two-component combinations leads to its target level within 3 months of therapy. 2. Taking a fixed combination of lisinopril and amlodipine is effective and safe. 3. Therapy using the combined drug VivaCor® in patients with high / very high risk of hypertension prevents further pathological remodeling of the heart. 4. The combination of amlodipine and lisinopril is metabolically neutral and well tolerated by patients. Keywords: arterial hypertension, lisinopril, amlodipine, VivaCor.

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Section: оригинальные исследованияunclassified

The optimal combination of Lysinopril and Amlodipine for the treatment of patients with hypertension

Джунусбекова

Tundybayeva²,

Leonovich

et al. 2020

Medicine

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The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)

Кочетков

Lopukhina²,

Kotaeva

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart.

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Cited by 2 publications

References 42 publications

The optimal combination of Lysinopril and Amlodipine for the treatment of patients with hypertension

The optimal combination of Lysinopril and Amlodipine for the treatment of patients with hypertension

The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)

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