Changes in the hematopoietic system and blood under the influence of heavy metal salts can be reduced with vitamin e

Romaniuk, Anatolii Mykolaiovych; Lyndin, Mykola Serhiiovych; Lуndіna, Yulia; Sikora, Vladyslav; Hrintsova, Natalia; Тимакова, О Ю; Gudymenko, Olena; Гладченко, О. М.

doi:10.5146/tjpath.2017.01412

Cited by 11 publications

(24 citation statements)

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“…2 ) -0.1 mg/l and chromium K 2 Cr 2 O 7 ) -0.1 mg/l. The selected concentration of salts in the mixture was due to the presence of such concentrations of these salts in the soil and drinking water of Ukraine some regions according to literature sources [1,2].…”

Section: Methodsmentioning

confidence: 99%

“…An important environmental problem in some northern regions of Ukraine today is the accumulation of heavy metal salts (zinc, chromium, lead, manganese, copper and iron) in soil, water and air, which is observed in various combinations depending on the region and causes adverse effects on people's health. Such a negative impact determines the development and course of oncological pathology, disorders of homeostasis and morphological transformations in various tissues [1,2]. The endocrine system together with the immune and nervous systems maintains homeostasis in the body.…”

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confidence: 99%

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Hryntsova¹,

Tymakova²,

Romaniuk³

2020

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An important environmental problem is the pollution of the environment with heavy metal salts, which are in various combinations depending on the region and cause adverse effects on public health. The endocrine system together with the immune and nervous system maintains homeostasis in the body. In order to study the morphofunctional rearrangements of the epiphyseal-parathyroid axis structural components in rats during 30 days of readaptation after 90 days of exposure to heavy metal salts (zinc (ZnSO4 · 7H2O) — 5 mg/l, copper (CuSO4 · 5H2O) — 1 mg/l, iron (FeSO4 ) — 10 mg/l, manganese (MnSO4 · 5H2O) — 0.1 mg/l, lead (Pb(NO3 ) 2 ) — 0.1 mg/l and chromium K2Cr2O7) — 0.1 mg/l) an experiment was performed on 24 white sexually mature male rats weighing 250–300 g, aged 7–8 months. The animals of the experimental group consumed ordinary drinking water for 30 days. Morphological, statistical, immunohistochemical and biochemical research methods were used. The 30-day period of readaptation after 90 days of heavy metal salts intake is insufficient to completely restore homeostasis in the epiphyseal-parathyroid system, which is at the stage of chronic stress «subcompensation». Significant morphological changes on the part of the vascular bed of the pineal gland and parathyroid glands (blood stasis, erythrocyte aggregation, sludge phenomenon) were determined, an active glial reaction was formed in the pineal gland, and the structure of the epithelial trabeculae of the glands was disturbed. The levels of parathyroid hormone and calcium in the blood of experimental animals were significantly lower than those of experimental animals. There is a greater vulnerability and faster dynamics of the regenerative processes in the parathyroid glands to the action of salts of heavy metals in comparison with the pineal gland. The development of hypofunction of the parathyroid glands, of course, has a negative effect on the overall calcium metabolism in the body, the development of compensatory and adaptive processes and the course of the general adaptation syndrome in response to the damaging agent.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Hryntsova¹,

Tymakova²,

Romaniuk³

2020

PEP

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“…The experimental group included rats, which for 90 days received drinking water with a mixture of heavy metal salts: zinc (ZnSO 4 ×7H 2 O) -5 mg/l, copper (CuSO 4 ×5H 2 O) -1 mg/l, iron (FeSO 4 ) -10 mg/l, manganese (MnSO 4 ×5H 2 O) -0.1 mg/l, lead (Pb(NO 3 ) 2 ) -0.1 mg/l, and chromium (K 2 Cr 2 O 7 ) -0.1 mg/l. The selected concentration of salts in the mixture was due to the presence of such concentrations of these salts in the soil and drinking water of some regions in Ukraine according to literature sources (Romanjuk et al, 2018a(Romanjuk et al, , b, 2019.…”

Section: Experimental Microelementosis Modelmentioning

confidence: 99%

“…Pollution with heavy metal salts is an important environmental problem today, having an adverse effect on public health. Such a negative effect determines development and course of oncological pathology, disorders of the body homeostasis and morphological transformations in various tissues (Romanjuk et al, 2018a(Romanjuk et al, , 2019, as each trace element with excessive exposure can be potentially toxic (Bharti et al, 2014). It is believed that the formation of free radicals, lipid peroxidation and changes in the antioxidant defence system play an important role in the toxic effects of heavy metals.…”

Section: Introductionmentioning

confidence: 99%

A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts

et al. 2022

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Pollution with heavy metal salts is an important environmental problem today, having an adverse effect on public health. The endocrine system maintains homeostasis in the body. The antioxidant protection (GPX-1) of the pineal gland in mature rats was studied. Animals of the experimental group represented a model of microelementosis, achieved by adding a mixture of heavy metal salts for 90 days to drinking water: zinc (ZnSO4×7H2O) – 5 mg/l, copper (CuSO4×5H2O) – 1 mg/l, iron (FeSO4) – 10 mg/l, manganese (MnSO4×5H2O) – 0.1 mg/l, lead (Pb(NO3)2) – 0.1 mg/l, and chromium (K2Cr2O7) – 0.1 mg/l. Morphological, statistical and immunohistochemical (GPX-1) research methods were used. Long-term (90-days) intake of heavy metal salts mixture in the body of experimental animals brought about development of the general adaptation syndrome, the stage of chronic stress “subcompensation” in the pineal gland. Morphological rearrangements were of nonspecific polymorphic nature as severe hemodynamics disorder in the organ, impairment of vascular wall morphology, development of tissue hypoxia and oxidative stress, accompanied by processes of accelerated apoptosis in part of pinealocytes, by a significant decrease in glutathione peroxidase level in the organ and reactive astrogliosis as a response to the damaging agent’s action. Along with the negative changes in the pineal gland, a compensatory-adaptive processes with signs of functional stress also occurred. A sufficiently high degree of glutathione peroxidase activity in 39% of pinealocytes located perivascularly, active adaptive glial reaction and activation of synthetic processes in some pinealocytes were also observed.

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“…Pollution by salts of heavy metals is an important environmental problem today, which negatively affects the health of the population. Such a negative impact determines the development of various pathologies, disruption of the body's homeostasis and morphological transformations in various tissues [24,25], since each trace element is potentially toxic in case of excessive exposure [5]. Various human diseases and toxicity are often associated with oxidative stress [5].…”

Section: Introductionmentioning

confidence: 99%

Morphological changes of sexually mature rat's pineal gland and cerebellar cortex under long-term exposure to heavy metal salts

et al. 2022

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Pollution with heavy metal salts is an important environmental problem today, having an adverse effect on public health. The endocrine system maintains homeostasis in the body. The purpose of the work is to study the morphological changes of the cerebellar cortex and epiphyses of sexually mature male rats under the condition of long-term exposure to the body of a complex of heavy metal salts. The morphological changes in the cerebellar cortex and epiphysis of sexually mature male rats under the condition of long-term exposure to heavy metal salts was studied. Animals of the experimental group were simulated microelementosis by adding to drinking water a mixture of heavy metal salts for 60 days: zinc (ZnSO4×7H2O) – 5 mg/l, copper (CuSO4×5H2O) – 1 mg/l, iron (FeSO4) – 10 mg/l, manganese (MnSO4×5H2O) – 0.1 mg/l, lead (Pb(NO3)2) – 0.1 mg/l and chromium (K2Cr2O7) – 0.1 mg/l. Morphological, morphometric and statistical research methods were used. Long-term (60-days) intake of heavy metal salts mixture in the body of experimental animals leads to the development of the general adaptation syndrome, the stage of chronic stress “subcompensation” in the pineal gland. Morphological changes in the organs had a nonspecific polymorphic character, such as a sharp violation of hemodynamics, a violation of the morphology of the vascular wall, the state of pinealocytes and Purkinje cells, the development of tissue hypoxia, processes of apoptosis and reactive astrogliosis as a response to the action of a damaging agent. The pineal gland of the experimental animals showed signs of indole production, but the evacuation of hormones (including melatonin) into the vascular bed was hampered due to the violation of the morphology of the vascular wall and the cell membrane of pinealocytes. This led to a deficiency of this hormone in the body of the experimental animals, which negatively affected the adaptive processes in the cerebellar cortex in response to the action of the stress agent. Compensatory and adaptive processes in the pineal gland and cerebellar cortex had signs of functional stress. Adaptive processes were observed both in a small number of pinealocytes and in Purkinje cells, as well as an active adaptive glial reaction in both organs.

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Changes in the hematopoietic system and blood under the influence of heavy metal salts can be reduced with vitamin e

Cited by 11 publications

References 5 publications

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A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts

Morphological changes of sexually mature rat's pineal gland and cerebellar cortex under long-term exposure to heavy metal salts

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