Changes in the Content of Microelements and Oxidative Stress Indices in Children With Chronic Bronchopulmonary Pathology

Abstract

Data on the analysis of changes in the content of antioxidants and pro-oxidants, as well as copper, zinc, iron, magnesium cations in the blood plasma and concentrations of these ions in erythrocytes in patients with chronic bronchopulmonary disease (CBPD) complicated by pulmonary arterial hypertension (PAH) are presented. 288 children with congenital malformations of bronchi and lungs and cystic fibrosis were examined. Patients were divided into 4 groups: 1. CBPD without both chronic pulmonary heart (CPH) and PAH (n = 110); 2. Children with both CBPD and PAH (n = 80); 3. Patients with CBPD and forming CPH (FCPH) against the background of PAH (n = 46); 4. Children with both CBPD and CPH (n = 52). Reference data were obtained in 20 conditionally healthy children. An increase in the concentrations of free intra-erythrocyte iron (Fein) in CBPD patients has been established. A significant increase in Fein, especially pronounced in group 1 patients and gradually decreasing in other patients, indicates to a progressive oxidative stress and the involvement of more and more free iron in it. A significant increase in the activity of hydroperoxides (HP) in CPHLS indicates to an increase in the levels of organic peroxides and compensation for a decrease in the activity of superoxide dismutase (SOD) and other antioxidants. In CPH patients, the ratio of anti- and pro-oxidants Zn/Cu and Znin/Cuin decreases compared to CBPD patients without CPH. The authors believe that in the complex treatment of CBPD in children it is necessary to provide the prescription of iron and zinc chelators to prevent the intensification of oxidative stress underlying the development of multiple organ failure in these forms of bronchopulmonary pathology