Community-acquired pneumonia (AP) caused by infectious agents is a dangerous respiratory disease that can lead to death. This determines the relevance of the topic. Materials and methods. A descriptive epidemiological study was conducted: the analysis of the primary incidence of community-acquired pneumonia in children from 1 month of age up to 17 years. Results. The incidence of AP among children in 2014-2018 on the RD was 286.9 per 100 thousand children and adolescents. Among children aged 6 months up to 1 year, AP was detected in 599.9 per 100 thousand surveyed. The obtained data on the EAP show that this indicator throughout the country did not exceed the Russian level, as well as the level of AP morbidity in the North Caucasus Federal district. The analysis of infant mortality from respiratory diseases showed a decrease in its level from 0.5% in 2014 to 0.2% in 2018 in the whole RD, including in rural areas, there was a decrease in the mortality rate from pneumonia from 0.5% to 0.3%, in urban areas from 0.4% to 0.1% over the observed period. Conclusion. The established patterns may lead to the discovery of new diagnostic biomarkers of AP and bring us closer to its personalized therapy in children.
There are presented data from a comprehensive examination and treatment of 30 children with community-acquired pneumonia (CAP). For the treatment of young children with focal-confluent forms of CAP and the clinical manifestations of infectious-septic shock, Pentaglobin preparations containing IgM were used. Severe CAP with a tendency to destruction was more often observed in cases with the dominance of gram-negative flora in the etiological structure, most often detected in the foothill zone (18.2% of children), in the middle mountain zone - in- 13.3%, in the low-grade zone - in 5% of children. Pseudomonas aeruginosae was more commonly seeded in children in the foothill zone (12.5%), while in children living in the lowland and middle mountain zone in 2.5% and 6.6% correspondingly. The authors showed the preparation of intravenous immunoglobulin Pentoglobin is a safe, effective, easily tolerated means of etiotropic and pathogenetic therapy of severe CAP, caused more often by gram-negative and gram-positive bacterial microbiota.
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