Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green

Silva, V.M; Chen, C; Hennig, Gayle E.; Whiteley, Herbert E.; Manautou, José E.

doi:10.1016/s0278-6915(00)00138-1

Cited by 19 publications

(19 citation statements)

References 29 publications

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“…The degree of necrosis was expressed as the mean of 10 high power fields (HPFs), chosen at random and classified on a scale of 0–5 (no hepatocyte necrosis, 0; necrosis in few hepatocytes, 1; necrosis in more than 10% but less than 24% of hepatocytes, 2; necrosis in more than 25% but less than 39% of hepatocytes, 3; necrosis in more than 40% but less than 49% of hepatocytes, 4; and necrosis in more than 50% of hepatocytes, 5) as per Silva et al. [19].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Mujahid

Hussain

Siddiqui

et al. 2017

Journal of Ayurveda and Integrative Medicine

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BackgroundErythrina indica Lam. traditionally used in the treatment of laxative, diuretic, worm infestation, liver ailment and joints pain.ObjectiveTo evaluate the antihepatotoxic potential of Erythrina indica against isoniazid (INH) and rifampicin (RIF) induced hepatotoxicity in rats.Methods and materialLiver toxicity was induced by antitubercular drugs (INH+ RIF) at dose level of 50 mg/kg each, p.o for 28 days. 50% methanolic extract of Erythrina indica (100 and 200 mg/kg) were administered orally once daily for 28 days. The hepatoprotective activity was assessed using various biochemical parameters SGOT, SGPT, ALP, bilirubin, total protein, albumin and LDH. Meanwhile, in vivo antioxidant activities as SOD, CAT, GSH and, LPO were measured in liver homogenate also histological examinations were carried out to assess hepatoprotective activity.Statistical analysis usedThe values were subjected to one way analysis of variance (ANOVA) followed by Tukey multiple compare test. Results were considered statistically significant when P < 0.05.ResultsObtained results demonstrated that the treatment with Erythrina indica (E. indica) significantly prevented drug induced increase in serum levels of hepatic enzymes. Furthermore, Erythrina indica significantly reduced the lipid peroxidation (P < 0.01 tp P < 0.001) in the liver tissue and restored activities of defense antioxidant enzymes GSH (2.15 ± 0.08 to 2.48 ± 0.99; P < 0.05), SOD (2.69 ± 0.752 to 3.712 ± 0.056; P < 0.05 to P < 0.01) and CAT (10.20 ± 0.58 to 12.59 ± 0.42; P < 0.05 to P < 0.001) towards normal. Histopathology of liver tissue showed that Erythrina indica attenuated the hepatocellular necrosis, regeneration and repair of cells toward normal.ConclusionThe results of this study strongly indicate the protective effect of Erythrina indica against liver injury which may be attributed to its hepatoprotective activity, and there by scientifically support its traditional use.

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Section: Methodsmentioning

confidence: 99%

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Mujahid

Hussain

Siddiqui

et al. 2017

Journal of Ayurveda and Integrative Medicine

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“…Liver sections (3 m) were prepared, stained with Hematoxylin and Eosin (H&E) and graded for lesions by light microscopy using the following scale (0-5). No lesions = 0; minimal lesions involving single to few necrotic cells = 1; mild lesions, 10-25% necrotic cells or mild diffuse degenerative changes = 2; moderate lesions, 25-40% necrotic or degenerative cells = 3; marked lesions, 40-50% necrotic or degenerative cells = 4; severe lesions more than 50% necrotic or degenerative cells = 5 (Silva et al, 2001). Persons unaware of treatments evaluated the liver sections from different groups.…”

Section: Histological Analysismentioning

confidence: 99%

Protective effect of α- and β-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice

Oliveira

Chaves

Almeida

et al. 2005

Journal of Ethnopharmacology

139

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“…18) It is also evident that pretreatment with FSSC, which produced significant quantities of glutathione-related thiol compounds and mineral elements (e.g., selenium and zinc), suppressed AAP-induced liver injury. Marked elevations in plasma AST and ALT activities associated with AAP toxicity were reduced by FSSC in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 98%

Protective Effect of a Fermented Substance fromSaccharomyces cerevisiaeon Liver Injury in Mice Caused by Acetaminophen

Lai

Fang

Hsieh

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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The protective effect of a fermented substance from Saccharomyces cerevisiae (FSSC) on liver injury caused by acetaminophen (AAP) was studied in mice. Mice were pretreated with FSSC (0.5-2.0 g/kg, p.o.) for 4 d, and on the fourth day, the mice received an overdose of AAP (500 mg/kg, i.p.). Subsequently, they were sacrificed at 7 h, and blood was drawn from the abdominal vein and liver samples were collected. Histological and biochemical examinations revealed that the administration of AAP caused liver injury in the mice, including increases in plasma alanine aminotransferase and asparate aminotransferase activities and decreases in the hepatic reduced form of glutathione (GSH) content and antioxidant enzyme activities. Prior to AAP treatment, the mice pretreated with FSSC showed significantly reduced levels of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) activity. Liver histology in the FSSC-pretreated mice was significant. In these mice, pretreatment with FSSC also served to reduce hepatic GSH depletion and the inhibition of antioxidant enzyme activity caused by AAP overdose. In conclusion, oral administration of FSSC significantly reduced AAP-induced hepatic injury in the mice.

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Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green

Cited by 19 publications

References 29 publications

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Protective effect of α- and β-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice

Protective Effect of a Fermented Substance fromSaccharomyces cerevisiaeon Liver Injury in Mice Caused by Acetaminophen

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