Changes in some hematological and biochemical indices of rabbits induced by isoflavones and cypermethrin

Yousef, Mokhtar I.; El‐Demerdash, Fatma M.; Kamel, K.I.; Al‐Salhen, K. S.

doi:10.1016/s0300-483x(03)00145-8

Cited by 171 publications

(111 citation statements)

References 45 publications

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“…The elevated blood urea is correlated with an increased protein catabolism in the mammalian body or more efficient conversion of ammonia to urea as a result of increased synthesis of enzymes involved in urea production (Rodwell 1979). Urea is the end-product of the protein catabolism and this is confirmed by the decrease in plasma proteins and referred to kidney dysfunction as proven by enlargement of the relative weight of kidney as suggested by Yousef et al (2003). Additionally, the recorded oxidative stress that is indicated by the current elevation in MDA due to GA 3 administration is an agreement with various studies (De Melo et al 1998;Soliman et al 2010).…”

Section: Discussionsupporting

confidence: 76%

Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations

Hassan

Al-Rawi

2012

Cytotechnology

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The present study aims to investigate the heptonephro-protective effect of grape seeds proanthocyanidin extract (GSPE) against the risks induced by gibberellic acid (GA3) in male rats. The results recorded that GA3 caused a significant increase in total lipids, total cholesterol, triglycerides and LDL-C levels in serum, concomitant with a significant decrease in serum HDL-C. A significant increase in serum AST, ALT, urea and creatinine, while, a significant decrease in total protein content in serum was observed in rats given GA3. Hepatic and renal lipid peroxidation product (MDA) was significantly increased, meanwhile, total antioxidant capacity (TAC), glutathione, and catalase levels were significantly decreased. In addition, there was a negative change in liver structure including dilatation in the central veins with degeneration of endothelium cells and cellular injury around the veins as well as in the kidney structure such as lesion in both glomeruli and tubules, detachment of the Malpighian corpuscles from the Bowman's capsule's epithelium, shrinkage in the glomerular capillary network. However, almost all of these adverse effects seemed to be ameliorated by oral administration of GSPE with GA3 to rats for 2 month indicating the protective effect of grape seeds GSPE on GA3 induced oxidative stress in rats.

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Section: Discussionsupporting

confidence: 76%

Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations

Hassan

Al-Rawi

2012

Cytotechnology

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“…In previous studies, the influence of cypermethrin on biochemical parameters in various animal species, and those of detoxifying substances used for the alleviation of intoxication arising from the pesticides have been investigated. The detoxifying substances were determined to have had positive effects on these parameters [8,45]. In the present study, propolis, which has not previously been used as a detoxifier, was demonstrated to display beneficial effects on most of these parameters, by returning their values close to those of the control group after cypermethrin insult.…”

Section: Administration Of Cypermethrin Plus Propolismentioning

confidence: 56%

“…In these studies, oxidative stress markers and other biochemical parameters [7,13,22,27,31], and changes in these parameters upon the administration of detoxifying substances have been investigated [8,14,15,24,45]. However, no previous studies related to effectiveness of propolis against acute cypermethrin exposure exist.…”

Section: Discussionmentioning

confidence: 99%

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

et al. 2008

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“…7 Moreover, the liver, being the primary site for pyrethroid metabolism ultimately led to liver damage, and was found to accumulate large amounts of pyrethroid residues. 8 Several investigations have reported that pesticides adversely affect testicular functions in experimental animals 6,[9][10][11] and function as potent endocrine disrupters. 12,13 Few reports have demonstrated the induction of oxidative stress by pyrethroids.…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Das¹,

Ghosh²,

Paramanik³

et al. 2017

Toxicol Forensic Med Open J

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CitationPesticides are used frequently and may have various adverse effects on human health in different ways. Cypermethrin (CYP) is a synthetic type II pyrethroid pesticide that has been used extensively to control a wide variety of pests in agriculture, forestry, horticulture, and public health. Objectives: This study aimed to investigate the dose-dependent hematological, hepatic and gonadal toxicity of CYP in mature male and female Wistar rats. Methods: Rats were randomly divided into nine groups, different doses of CYP were administered for 14 consecutive days and different hematological, hepatic and gonadal parameters were assayed. Results: Erythrocyte count, hemoglobin percentage, hepatic reduced glutathione (GSH) content and sperm count were significantly diminished. Serum aspartic and alanine transaminase, hepatic malondialdehyde (MDA), testicular cholesterol content were increased following CYP treatment in male rats at 40 and 80 mg/kg body weight (1/9 and 1/4.5 LD 50 ). Elevated ovarian cholesterol content and decreased 17β hydroxy steroid dehydrogenase (HSD) levels were also observed in CYP-exposed female rats at a dose level of 34.33 and 51.5 mg/kg body wt. (1/9 and 1/6 LD 50 ). Conclusion: Taken together, CYP initiated hematological, hepatic and gonadal toxicity in mature male rats with a body weight of 40 mg/kg (1/9 LD 50 ) and gonadal toxicity in mature female rats with a body weight of 34.33 mg/kg (1/9 LD 50 ) and above.

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Changes in some hematological and biochemical indices of rabbits induced by isoflavones and cypermethrin

Cited by 171 publications

References 45 publications

Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations

Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

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