Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Eraslan, Gökhan; Kanbur, Murat; Silici, Sibel; Altınordulu, Şule; Karabacak, Mürsel

doi:10.1538/expanim.57.453

Cited by 42 publications

(33 citation statements)

References 37 publications

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“…Plasma TG also increased significantly in their study. TG levels in our study increased progressively until the end of treatment, as has been observed during acute CYP intoxication reported in other studies at higher doses (Eraslan et al, 2008). In relation to albumin, an acute phase protein, our results indicated that doses of CYP and DEL which were above permissible limits, caused a decrease albumin levels.…”

Section: Discussionsupporting

confidence: 87%

Hepatic Effects from Subacute Exposure to Insecticides in Adult Male Wistar Rats

Aldana-Madrid¹,

Shibayama²,

Calderon³

et al. 2012

Insecticides - Advances in Integrated Pest Management

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Section: Discussionsupporting

confidence: 87%

Hepatic Effects from Subacute Exposure to Insecticides in Adult Male Wistar Rats

Aldana-Madrid¹,

Shibayama²,

Calderon³

et al. 2012

Insecticides - Advances in Integrated Pest Management

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“…However, in the propolis+CA group, the plasma urea level demonstrated to be significantly decreased compared with the levels in the CA group. Eraslan et al (27) have reported similar effects. In both groups administered with propolis, increase in uric acid levels may be related to either the increase in protein degradation, which is involved in uric acid formation, or the influence of propolis on the kidneys.…”

Section: Discussionmentioning

confidence: 76%

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Baykara

Silici

Özçelik³

et al. 2015

Diagn Interv Radiol

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C ontrast agents are often used in diagnostic imaging or interventional procedures in clinical radiology or nuclear medicine for the purpose of providing contrast enhancement in images. Additional contrast improves the accuracy of detecting pathologic abnormalities in the underlying biological system or the outcome of the intervention. Some of the contrast agents, however, expose the patient to toxic side effects. Diatrizoate is one of those radiocontrast agents used for imaging kidney and its related structures. It has a high-osmolality and contains iodine for absorption of X-rays and hence for producing localized hyperintensities in computed tomography images. In patients with kidney dysfunction, as measured by serum creatinine clearance level of less than 60 mL/min, diatrizoate may lead to kidney failure (1). This effect is called contrast-induced nephropathy (CIN) and constitutes one of the most common causes of hospital-acquired renal failures in clinical practice. Therefore, it is important to develop preventive and/or protective strategies for safeguarding the kidney to be exposed to diatrizoate.Diatrizoate induces kidney damage through a combination of renal ischemia and direct toxic effect on renal tubular cells (2). The mechanism of pathogenesis includes factors such as impaired nitric oxide production, blockade of vasodilation and generation of reactive oxygen species, all promoting oxidative stress. For preventing kidney from acquiring CIN, past attempts were focused on interventions against toxicity and oxidative stress. In this regard, pharmaceuticals N-acetylcystein (NAC) and calpain inhibitor-1 were investigated and determined to be effective (3). As alternative to such man-made pharmaceuticals, natural compounds found in folk medicine have also gained popularity as viable options in health care. The natural product propolis has been explored on various fronts and its therapeutic

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“…Decreased activity of SOD and CAT has been reported in rats exposed to pyrethroids (Eraslan, Kanbur, and Silici 2008;Hussein, Elnaggar, and Al-Dailamy 2012). Significant decrease in the activity of GPx (Raina et al 2009;Dubey, Raina, and Khan 2012;Dubey, Khan, and Raina 2013;Khan et al 2013b;Dar et al 2013) and GST (Singh, Saxena, and Sharma 2009;Dar et al 2013) has also been reported with several pyrethroids in various tissues.…”

Section: Discussionmentioning

confidence: 95%

Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Dar

Khan

Raina

et al. 2015

Toxicological & Environmental Chemistry

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The oxidative-stress-inducing potential of the pyrethroid, bifenthrin, in the brain of rats was evaluated following daily oral administration of 5.8 mg/kg body weight. Lipid peroxidation in the brain was increased, while the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase decreased. The activity of acetylcholinesterase (AChE) in erythrocytes and brain also decreased. Bifenthrin induces severe oxidative stress in brain, and inhibits brain and erythrocyte AChE.

show abstract

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Abstract: SOD and CAT, liver SOD and GSH-Px, kidney SOD and brain SOD, CAT and GSH-Px

Cited by 42 publications

References 37 publications

Hepatic Effects from Subacute Exposure to Insecticides in Adult Male Wistar Rats

Hepatic Effects from Subacute Exposure to Insecticides in Adult Male Wistar Rats

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

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