Changes in Soluble Adhesion Molecules in Gingival Crevicular Fluid Following Periodontal Surgery

Kuru, Leyla; Kirby, Alun C.; Griffiths, Gareth; Petrie, Aviva; Olsen, I

doi:10.1902/jop.2005.76.4.526

Cited by 7 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early post‐operative GCF volume increases are consistent with previous reports (Cattermole & Wade , Kuru et al. , ). However, early post‐operative PICF volume changes are reported for the first time.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Peri‐implant versus periodontal wound healing

Emecen‐Huja

Eubank

Shapiro

et al. 2013

J Clinic Periodontology

View full text Add to dashboard Cite

Aim Peri-implant gingival healing following one-stage implant placement was investigated and compared to periodontal healing. Methods Healing at surgical sites (implant (I) and adjacent teeth (T+)) was compared to non-operated tooth (T-) in non-smokers receiving one-stage implant. Periodontal Indices (PI, GI) were recorded at surgery and up to 12 weeks postoperatively. Peri-implant (PICF) and gingival crevicular (GCF) fluids were analyzed for cytokines, collagenases and inhibitors. Data was analyzed by linear mixed model regression analysis and repeated measures ANOVA. Results 40 patients (22 female; 21-74 yrs old) completed the study. Surgical site GI, increased at week 1, decreased significantly during early healing (weeks 1-3; p=0.0003) and continually decreased during late healing (weeks 6-12) for I (p<0.01). PICF volume decreased 3-fold by week 12 (p=0.0003). IL-6, IL-8, MIP-1β, and TIMP-1 levels significantly increased at surgical sites at week one, significantly decreasing thereafter (P<0.016). Week one IL-6, IL-8 and MIP-1β levels were ~3-fold higher, and TIMP-1 levels 63% higher, at I compared to T+ (p=0.001). Conclusion Peri-implant gingival healing, as determined by crevicular fluid molecular composition, differs from periodontal healing. The observed differences suggest that peri-implant tissues, compared to periodontal tissues, represent a higher pro-inflammatory state.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Kuru et al. (, ) also studied GCF composition during early post‐operative healing following surgery in “control” teeth (T+ equivalent) receiving crown lengthening; however, their GCF analysis was limited to TGFβ1 and specific adhesion molecules, thus precluding comparisons to the results reported here.…”

Section: Discussionmentioning

confidence: 96%

Peri‐implant versus periodontal wound healing

Emecen‐Huja

Eubank

Shapiro

et al. 2013

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…However, in contrast to the present intervention study, CAM levels were measured locally in the gingival crevicular fluid in these studies. Local total sICAM‐1 levels were reported to decrease during intervention in these studies, 29,30 whereas local sE‐selectin and sVCAM‐1 levels were not affected.…”

Section: Discussionmentioning

confidence: 67%

“…In one large cohort study, 28 circulating ICAM‐1 levels were systemically increased in periodontal inflammation, represented by increased bleeding on probing. Also, it was shown 29,30 that therapeutic intervention through SRP and periodontal surgery decreases CAM expression. However, in contrast to the present intervention study, CAM levels were measured locally in the gingival crevicular fluid in these studies.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicate upregulated CAM expression during periodontal inflammation 22‐28 . Also, studies suggest that scaling and root planing (SRP) and periodontal surgery decrease total sICAM‐1 levels in the gingival crevicular fluid 29,30 . However, it is not clear whether a therapeutic intervention in the periodontium influences systemic CAM levels.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Influence of Periodontal Therapy on the Regulation of Soluble Cell Adhesion Molecule Expression in Aggressive Periodontitis Patients

Pischon

Hägewald

Kunze

et al. 2007

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review

et al. 2019

View full text Add to dashboard Cite

Background Surgical treatments such as guided tissue regeneration (GTR) and access flap surgery are widely employed for the treatment of intrabony defects. However, little is known regarding the postoperative expression of gingival crevicular fluid (GCF) markers. Objective The aim of this systematic review was to compare the expression of GCF markers following treatment of periodontal intrabony defects with guided tissue regeneration or access surgery. The association of the markers' expression with the clinical outcome was also assessed. Methods An electronic literature search was conducted in MEDLINE, EMBASE, OpenGrey, LILACS and Cochrane Library up to December 2018 complemented by a manual search. Human, prospective clinical studies were identified. The changes from baseline up to 30 days (early healing) and 3 months (late healing) were assessed. Results A total of 164 publications were identified and reviewed for eligibility. Of these, 10 publications fulfilled the inclusion criteria. The included studies evaluated 15 different GCF markers with a follow-up time between 21 and 360 days postoperatively. PDGF, VEGF and TIMP-1 changes were often investigated in the included studies; however, contrasting results were reported. Two studies agreed that both GTR and OFD lead to similar OPG level changes. TGF-β1 is increased early postoperatively, irrespective of the surgical technique employed. Conclusion There is limited evidence available on the expression of GCF markers after surgical interventions of intrabony periodontal defects. However, OPG and TGF-β1 tend to increase early post-operatively, irrespective of the surgical technique employed, irrespective of the surgical technique employed. Clinical relevance More well-designed, powered studies with sampling periods reflecting the regenerative process are needed, and future research should focus on employing standardised protocols for collecting, storing and analysing GCF markers.

show abstract

Changes in Soluble Adhesion Molecules in Gingival Crevicular Fluid Following Periodontal Surgery

Cited by 7 publications

References 38 publications

Peri‐implant versus periodontal wound healing

Peri‐implant versus periodontal wound healing

Influence of Periodontal Therapy on the Regulation of Soluble Cell Adhesion Molecule Expression in Aggressive Periodontitis Patients

Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review

Contact Info

Product

Resources

About