Influence of Periodontal Therapy on the Regulation of Soluble Cell Adhesion Molecule Expression in Aggressive Periodontitis Patients

Abstract

Periodontal therapy reduces plasma sE-selectin levels. Whether this leads to a reduction in risk of future cardiovascular events in patients with aggressive periodontal disease warrants further studies.

Evidence that periodontal treatment improves biomarkers and CVD outcomes

“…We retrieved evidence from six different clinical trials. A statistically significant reduction of soluble sE-selectin levels after periodontal therapy was reported in some of them , Pischon et al 2007. No evidence of a similar effect of periodontal therapy on sICAM-1 and sVCAM-1 was found (Lalla et al 2007, Pischon et al 2007, Marcaccini et al 2009a.…”

“…Note that D'Aiuto et al (2006) was not included, since there was no untreated control group. Other randomized trials that were not included were as follows: Pischon et al (2007) (groups had SRP -contrast was use or none use of an antibiotic), T€ uter et al (2007) (a study of host modulation therapy with lowdose doxycycline, LDD versus SRP) and Payne et al (2011) (only supportive periodontal therapy in both groups with one group receiving LDD).…”

“…Buhlin et al (2009) reported significant changes in IL-18 12 months after periodontal therapy, but not in other ILs (-1b, -4, -5, -6, -8, -10). A number of clinical trials reported no efficacy of periodontal therapy on ILs profiles (Lalla et al 2007, Pischon et al 2007, Correa et al 2010) and these are summarized in Appendix S6. The most consistent finding was a reported increase of IL-6 levels following periodontal therapy in the short term (1 month) and some evidence of a reduction in IL-6 levels in the medium terms (6 months).…”

Lipoproteins and lipoprotein metabolism in periodontal disease

“…The effects of periodontal treatment on circulating hsCRP are subject to modulation by confounders, such as obesity [185]. Soluble cell adhesion molecules are elevated in subjects with generalized aggressive periodontitis [33,39], but soluble E-selectin declines when subjects are treated by scaling and root planing [186]. Periodontal therapy also ameliorates subclinical indices of atherosclerosis.…”

Initial Periodontal Therapy Reduced Systemic and Local 25‐Hydroxy Vitamin D3 and Interleukin‐1β in Patients With Aggressive Periodontitis

“…In a previous study, 16 we demonstrated that plasma levels of IL‐6 of patients with GAgP were significantly higher than those of the healthy controls. A study by Pischon et al 17 indicated that plasma IL‐6 levels of patients with AgP did not significantly change after periodontal therapy. To our knowledge, the impact of periodontal therapy on IL‐6 levels in the GCF of patients with GAgP has not been reported and needs further study.…”