Changes in Prealbumin, Nutrient Intake, and Systemic Inflammation in Elderly Recuperative Care Patients

Dennis, Richard A.; Johnson, Larry E.; Roberson, Paula K.; Heif, Muhannad; Bopp, Melinda M.; Cook, Judy; Sullivan, Dennis H.

doi:10.1111/j.1532-5415.2008.01789.x

Cited by 43 publications

(36 citation statements)

References 23 publications

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“…PA as a negative acute phase protein, 6-8 h after the stress state, can be a noticeable change. It has been confirmed serum PA levels decline in a variety of diseases, such as kidney injury, systemic inflammation, liver cirrhosis, brain trauma [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Gao

Zhang

et al. 2010

Clin Exp Med

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Low serum protein and albumin are considered to significantly associate with malnutrition, impaired functional status, poor outcome, and mortality. We hypothesized that serum prealbumin (transthyretin, PA) was a reliable and robust survival marker in young cerebral infarction patients and attempted to test the foregoing hypothesis. We analyzed the relationship between serum PA and stroke severity as determined by the modified Rankin Scale at discharge in 585 young cerebral infarction patients. By multivariate logistic regression modeling, we determined the influence of prealbumin on stroke severity, and the analyses were adjusted for the effects of potential confounders. Patients with a severe stroke had significantly more often prealbumin on admission in the lowest quintile (P = 0.031). Those cardiogenic cerebral infarction patients had significantly lower serum prealbumin concentrations and higher mRS scores. A logistic regression adjusted for confounders confirmed the following independent (odds ratio, 95% CI) good outcome predictors: uric acid (-0.002, 0.996-1.000) and prealbumin (-0.003, 0.995-1.000). Prealbumin is an independent predictor of the good clinical outcome of young cerebral infarction patients. The serum prealbumin may be a useful prognostic indicator for judging the prognosis of cerebral infarction.

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Section: Discussionmentioning

confidence: 99%

Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Gao

Zhang

et al. 2010

Clin Exp Med

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“…However, in these patients, the serum prealbumin provides prognostic value independent of the serum albumin and other established predictors of mortality in this population 3,7. In the older patients, repeated measurement of prealbumin is used to provide an assessment of the adequacy of nutrient intake over time 13. Several studies have advocated the use of serum prealbumin, as a better surrogate of nutritional status in HD patient population 9,14.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Nutritional Parameters among Adult and Elderly Hemodialysis Patients

Çelik¹,

Öç²,

Kara³

et al. 2011

Int. J. Med. Sci.

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Aim: The aim of this study was to compare the nutritional biochemical parameters, prealbumin levels, and bioimpedance analysis parameters of adult and elderly hemodialysis (HD) patients.Methods: This prospective cross-sectional study included 50 adult HD patients (42.0 % female). Nutritional status was assessed by post-dialysis multifrequency bioimpedance analysis (BIA), serum prealbumin and other nutritional biochemical parameters.Results: Mean age of patients was 57.4±15.1 years (range: 30-83 years) and mean dialysis duration was 68.3 ± 54.5 months (range: 3-240 months). When the patients were divided into two groups according to age of patients (<65 and ≥65), prealbumin (p=0.003), blood urea nitrogen (BUN) (p=0.000), serum creatinine (p=0.013), albumin (p=0.016), protein catabolic rate per normalized body weight (nPCR) (p=0.001), intracellular water (ICW)/total body weight (0.003) , body fat mass (p00.000), lean body mass (p=0.031), lean dry mass (p=0.001), illness marker (p=0.005), basal metabolism (p=0.007), body mass index (BMI) (p=0.028), body fat mass index (BFMI) (p=0.000), fat free mass index (FFMI) (p=0.040) values were significantly different between the groups. In the elderly patients (age ≥65), body fat mass, illness marker, BMI, BFMI were higher compared to adult patients (age <65). Additionally, in the elderly patients, prealbumin, BUN, creatinine, albumin, nPCR, ICW/ total body weight, lean body weight, lean dry weight, basal metabolism and FFMI were lower than adult patients.Conclusions: Our results indicate that BFMI were higher, albumin, prealbumin, nPCR and lean body mass and FFMI were lower in elderly patients compared to adults. These results imply that elderly HD patients may be prone sarcopenic obesity and may require special nutritional support.

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“…Measurement of hepatic proteins such as prealbumin has been repeatedly demonstrated to be useful for monitoring of malnutrition [2–14]. However, the presence of several kinds of inflammation is recognized to be the most important factor affecting the serum level of hepatic protein, due to capillary leakage or alteration of normal hepatic protein metabolism [7, 14–17].…”

Section: Discussionmentioning

confidence: 99%

“…However, the presence of several kinds of inflammation is recognized to be the most important factor affecting the serum level of hepatic protein, due to capillary leakage or alteration of normal hepatic protein metabolism [7, 14–17]. The inflammation-associated cytokines, especially IL-6 and TNF-α, were demonstrated to play a central role in the acute-phase response, which can include a decline in serum concentration of albumin and prealbumin and an increase in CRP [15].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to albumin, the half-life of rapid turnover proteins (RTPs), such as prealbumin (transthyretin), retinol binding protein and transferrin, is relatively short, and the levels of serum RTPs are changed by alterations in nutritional intake and nutritional risk [6, 7, 9–14]. Therefore, RTP has been recognized as a more sensitive indicator of nutritional status than albumin.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Corrected Rapid Turnover Protein Increment Index (CRII) for Early Detection of Improvement of Nutrition Status in Patients with Malnutrition

Suyama

Adachi

Notsu

et al. 2009

J. Clin. Biochem. Nutr.

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Serum prealbumin level is useful for assessment of changes in nutritional status but it is markedly affected by the inflammation. In this study, we examined the efficacy of the corrected rapid turnover protein increment index (CRII) for prealbumin, which is calculated as [prealbumin level/C-reactive protein (CRP) level on the assessment day]/[prealbumin level/CRP level on the day of starting nutritional care], for prediction of improvement of nutritional status in patients with malnutrition. The subjects were 50 hospitalized patients with low albuminemia, who were receiving nutritional care. Serum concentrations of albumin, prealbumin and CRP were measured every week for 5 weeks. We defined patients whose serum albumin level was elevated by more than 0.2 g/dl after 5 weeks as those showing improved nutritional status. There was a significant difference in the prealbumin level between improved and unimproved patients at 5 weeks after the start of nutritional support. On the other hand, the prealbumin CRII value showed a significant difference between the groups at 1 and 2 weeks after the start of nutritional support. In conclusion, assessment of prealbumin CRII is useful for early prediction of improved nutritional status in patients with malnutrition.

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Changes in Prealbumin, Nutrient Intake, and Systemic Inflammation in Elderly Recuperative Care Patients

Cited by 43 publications

References 23 publications

Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Comparison of Nutritional Parameters among Adult and Elderly Hemodialysis Patients

Efficacy of Corrected Rapid Turnover Protein Increment Index (CRII) for Early Detection of Improvement of Nutrition Status in Patients with Malnutrition

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