Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Gao, Cong; Zhang, Bin; Zhang, WeiZhi; S, Pu; Yin, Jun; Gao, Qingchun

doi:10.1007/s10238-010-0103-8

Cited by 40 publications

(25 citation statements)

References 17 publications

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“…Transthyretin was independently associated with functional outcome at discharge and one-year mortality in stroke patients, after adjusting for potential confounders. As a matter of fact, one research group explored the similar field but this study has several concerns [15]. Participants were young (the mean age was 39 years) and have been enrolled only from Chinese population.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of serum transthyretin for outcome in acute ischemic stroke

et al. 2017

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IntroductionThe impact of choroid plexus with its blood–cerebrospinal fluid barrier in the ischemic stroke pathology is poorly explored. Transthyretin (TTR) is a protein synthesized in liver and just in choroid plexus.ObjectivesThe current study was designed to assess the prognostic value of serum TTR for functional outcome (at the time of hospital discharge) and long-term (one-year) overall mortality in ischemic stroke patients.Patients and methodsWe conducted a prospective observational study. Patients (n = 81) with acute (< 24 hours of symptoms onset) ischemic stroke consecutively admitted to Stroke Unit were included. An unfavorable outcome was defined as a modified Rankin Scale (mRS) score ≥ 3. The relationships between serum TTR levels and clinical outcome were analyzed using multivariate analysis. One-year mortality was analyzed by Kaplan–Meier survival curves stratified by mean value of TTR.ResultsCompared with patients with mRS <3, patients with an unfavorable outcome at hospital discharge had significantly lower TTR levels on admission (P < 0.0001). In non-survivals serum TTR levels were significantly lower compared with patients who survive one year of observation (P = 0.009). Using multivariate analysis, transthyretin emerged as an independent predictor for unfavorable outcome at the day of hospital discharge (adjusted odds ratio = 0.96; 95% CI: 0.9–0.99, P <0.05). A one-year mortality of patients with the lower TTR levels was significantly higher than in patients with TTR levels above mean value (P = 0.02).ConclusionsSerum level of TTR at admission was a predictor of functional outcome after ischemic stroke and was also associated with one-year mortality in stroke survivals.

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Section: Discussionmentioning

confidence: 99%

Predictive value of serum transthyretin for outcome in acute ischemic stroke

et al. 2017

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“…In patients with heart failure, cancer, and cerebral infarction, prealbumin has been shown to be a good predictor of prognosis [6], [7], [8]. It has been reported that serum prealbumin also has predictive value for TBI [9].…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin and Prealbumin Predict the Poor Outcome of Traumatic Brain Injury

Bao

et al. 2014

PLoS ONE

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BackgroundSerum albumin and prealbumin are both negative acute-phase reactants, and usually at low levels in stress. We aim to determine their predictive values for poor outcome of traumatic brain injury (TBI).MethodsA total of 326 patients of TBI were enrolled and followed-up by telephone 6 months after discharge. They were divided into a favorable group (GOS: 3 to 5) and an unfavorable group (GOS: 1 to 2). Serum albumin and prealbumin were measured from vein blood within 24 h after admission.ResultsNinety one (27.9%) patients were with poor outcome (GOS: 1 to 2). The unfavorable group had lower albumin and prealbumin (P<0.001). Albumin and prealbumin were both positively correlated with GCS (r = 0.489, P<0.001; r = 0.222, P<0.001, respectively) and GOS (r = 0.518, P<0.001; r = 0.314, P<0.001, respectively). After adjustment for confounding factors, the odds ratios of albumin and prealbumin were 0.866, 95% CI: 0.829 to 0.904 and 0.990, 95% CI: 0.985 to 0.995, respectively. In subgroup of GCS≤8 (n = 101), the crude and adjusted odds ratios of serum albumin were both statistically significant (P = 0.027, P = 0.033, respectively), while prealbumin were not (P = 0.553, P = 0.576, respectively). The AUC of albumin for predicting poor outcome was 0.762, 95% CI: 0.712 to 0.807, which was significantly higher than that of prealbumin (0.664, 95% CI: 0.610 to 0.715). In analyses of all patients and subgroup of GCS≤8, the AUCs of serum albumin were both significantly higher than those of prealbumin (P = 0.001, P = 0.045, respectively).ConclusionsBoth serum albumin and prealbumin could predict the poor outcome of TBI, but the former is much better, especially, in patients with severe TBI.

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“…However, in patients with acute stroke, lower serum albumin concentration predicted mortality during hospitalization and the need for institutional care [12]. In young patients with ischemic stroke, serum prealbumin (transthyretin, PA) was also an independent predictor of clinical outcome [24]. …”

Section: Malnutrition As a Risk Factor For Adverse Outcomesmentioning

confidence: 99%

Malnutrition in Patients with Acute Stroke

Bouziana

Τζιόμαλος

2011

Journal of Nutrition and Metabolism

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Stroke is a devastating event that carries a potential for long-term disability. Malnutrition is frequently observed in patients with stroke, and dysphagia contributes to malnutrition risk. During both the acute phase of stroke and rehabilitation, specific nutritional interventions in the context of a multidisciplinary team effort can enhance the recovery of neurocognitive function. Early identification and management of malnutrition with dietary modifications or specific therapeutic strategies to ensure adequate nutritional intake should receive more attention, since poor nutritional status appears to exacerbate brain damage and to contribute to adverse outcome. The main purpose of nutritional intervention should be the prevention or treatment of complications resulting from energy-protein deficit. This paper reviews the evaluation and management of malnutrition and the use of specialized nutrition support in patients with stroke. Emphasis is given to enteral tube and oral feeding and to strategies to wean from tube feeding.

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Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Cited by 40 publications

References 17 publications

Predictive value of serum transthyretin for outcome in acute ischemic stroke

Predictive value of serum transthyretin for outcome in acute ischemic stroke

Serum Albumin and Prealbumin Predict the Poor Outcome of Traumatic Brain Injury

Malnutrition in Patients with Acute Stroke

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