Changes in Pneumococcal Serotypes and Antimicrobial Resistance after Introduction of the 13-Valent Conjugate Vaccine in the United States

Richter, Sandra; Diekema, Daniel J.; Heilmann, Kristopher P.; Dohrn, Cassie L.; Riahi, Fathollah; Doern, Gary V.

doi:10.1128/aac.03344-14

Cited by 141 publications

(109 citation statements)

References 17 publications

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“…39 Richter describes an increase in serotype 35B pneumococcal infection in children from 2% in 1999-2000 to 9.1% in 2012-2013. 40 Similarly, Desai found that 9% and 11% of IPD in studied children in Atlanta were caused by serotypes 35B and 15B/C, respectively. 35 By 2015, the CDC's Active Bacterial Core Surveillance program showed that serotypes 15B/ C and 35B have emerged as 2 of the top 4 most frequent causes of IPD in children less than 5 years of age.…”

Section: Discussionmentioning

confidence: 87%

Nasopharyngeal pneumococcal carriage rates among HIV-infected adults following widespread pediatric use of conjugate pneumococcal vaccine-13

Feola

Bonville

Cibula

et al. 2016

Human Vaccines & Immunotherapeutics

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Background: Nasopharyngeal pneumococcal carriage rates among HIV-infected adults has not been described since conjugate pneumococcal vaccine-13 (PCV13) was added to the universal infant and childhood vaccination schedule in 2010. Methods: HIV-infected adults presenting for routine health care visits to the Designated AIDS Center in Syracuse, NY between December 2013 and June 2015 were eligible for enrollment. Demographic, medical, and social history were recorded after obtaining informed consent. Nasopharyngeal samples were collected and cultured for the presence of Streptococcus pneumoniae using standard microbiologic techniques. Antibiotic susceptibility testing was performed using E-test!. Results: 707 nasopharyngeal samples were collected from 414 HIV-infected adults. 18 samples were culture positive for S. pneumoniae; 1 (6%) isolate was of vaccine-type, 9 (50%) were non-vaccine types, and 8 (44%) were non-typeable. The 18 isolates were recovered from 15 different patients (4% of those enrolled). Three patients were culture positive for pneumococcus isolated from 2 consecutive samples, with non-typeable pneumococci identified consecutively from 2 patients and serotype 35B identified consecutively from 1 patient. The most commonly identified non-vaccine serotypes were 35B and 15B/C. Identified pneumococci were penicillin and cefotaxime susceptible. Conclusion: Four percent of HIVinfected adults in our study population were colonized with S. pneumoniae. The non-vaccine serotypes 35B and 15B/C predominated.

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Section: Discussionmentioning

confidence: 87%

Nasopharyngeal pneumococcal carriage rates among HIV-infected adults following widespread pediatric use of conjugate pneumococcal vaccine-13

Feola

Bonville

Cibula

et al. 2016

Human Vaccines & Immunotherapeutics

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“…Among the most prevalent serotypes, 5 studies reported 22F ( 6.0%) 6,24,57,60,61 and 4 studies reported 11A ( 14.0%). 24,[61][62][63] Further, among the 4 studies reporting IPD-related pneumococcal illness, 6,24,57,58 serotypes 8 (range: 1.6-3.8%) and 12F (1.9-5.9%) were reported in all of them and 9N (3.8% and 4.2%) 6,58 and 10A (1.9% and 1.0%) 6,58 were reported in 2 studies. For non-IPD related carriage or illness, the most prevalent serotype was 11A in all 3 studies.…”

Section: Pneumococcal Serotype Distribution Among Adults Aged 65 Y Anmentioning

confidence: 94%

“…For non-IPD related carriage or illness, the most prevalent serotype was 11A in all 3 studies. [60][61][62] Prevalence of serotypes 15B (1.0-2.6%) and 10A (1.8-4.0%) were also noteworthy. 60,62 Prevalence of serotypes not covered by any pneumococcal vaccines was reported in only 2 IPD studies, which reported serotypes 38 (5.2%) 58 and 6C (2.7%) 24 to be the most prevalent.…”

Section: Pneumococcal Serotype Distribution Among Adults Aged 65 Y Anmentioning

confidence: 98%

“…[60][61][62] Conjugate vaccine serotypes (i.e., serotypes included in PCV13) causing IPD among older adults were highly prevalent (> 60% of serotypes) in only 2 studies, one Polish 6 and one Spanish. 58 Conjugate vaccine serotypes were generally less prevalent among non-IPD conditions, the highest prevalence reported being 43% in a South Korean study.…”

Section: Pneumococcal Serotype Distribution Among Adults Aged 65 Y Anmentioning

confidence: 99%

“…60,62 Prevalence of serotypes not covered by any pneumococcal vaccines was reported in only 2 IPD studies, which reported serotypes 38 (5.2%) 58 and 6C (2.7%) 24 to be the most prevalent. Three non-IPD related carriage or illness studies, reported serotypes 15A (9.6%), 62 34 (6.1%) 60 and 6C (6.0%) 61 to be the most prevalent.…”

Section: Pneumococcal Serotype Distribution Among Adults Aged 65 Y Anmentioning

confidence: 99%

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Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

Cui

Patel²,

O’Neil³

et al. 2017

Human Vaccines & Immunotherapeutics

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Molecular characterization of Streptococcus pneumoniae isolated from pediatric patients in Shanghai, China

Wang

Cong

Huang

et al. 2020

Pediatric Pulmonology

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BackgroundStreptococcus pneumoniae is a major cause of bacterial infection among infants and young children with high morbidity and mortality. The serotype distribution of S. pneumoniae varies with geography, time, age, and disease.AimWe aimed to investigate the current status of molecular characteristics of S. pneumoniae strains isolated from pediatric patients in Shanghai, China.MethodsBetween 2016 and 2018, 73 clinical S. pneumoniae isolates were characterized by capsular serotype, multilocus sequence typing, antibiotic susceptibility, and resistant genes.ResultsThe most common serotypes were 19F (39.7%), 19A (16.4%), 6A (11.0%), 14 (9.6%), and 6B (8.2%). The coverage rates of the 7‐, 10‐ and 13‐valent pneumococcal conjugate vaccines were 64.4%, 64.4%, and 91.8%, respectively. The five predominant sequence types were ST271 (37.0%), ST320 (19.2%), ST3173 (11.0%), ST876 (6.8%), and ST81 (4.1%), which were mainly associated with serotypes 19F, 19A, 6A, 14, and 23F, respectively. The rates of resistance to penicillin and ceftriaxone were 21.9% and 39.7%, respectively. All strains displayed resistance to macrolides, 54.8% of which possessed both erm(B) and mef(A/E) genes, and 41.1% carried the erm(B) gene alone. Tn2010 (41.1%) was the most common transposon.ConclusionsClonal complex 271 (Taiwan19F‐14 clone) played a dominant role in the dissemination of pneumococcal isolates. The prevalent serotypes indicated a lack of the 7‐valent pneumococcal conjugate vaccine, which has not been included in national immunization programs in mainland China. The high rate of macrolide resistance made the empirical use of macrolides alone not suitable for treating pediatric pneumococcal disease.

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Changes in Pneumococcal Serotypes and Antimicrobial Resistance after Introduction of the 13-Valent Conjugate Vaccine in the United States

Cited by 141 publications

References 17 publications

Nasopharyngeal pneumococcal carriage rates among HIV-infected adults following widespread pediatric use of conjugate pneumococcal vaccine-13

Nasopharyngeal pneumococcal carriage rates among HIV-infected adults following widespread pediatric use of conjugate pneumococcal vaccine-13

Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

Molecular characterization of Streptococcus pneumoniae isolated from pediatric patients in Shanghai, China

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