Changes in ovarian activity during hepatocarcinogenesis by n-2-fluorenylacetamide: Role of alpha-fetoprotein

During chemical carcinogenesis by N-2-fluorenylacetamide, the hormonal status of female Sprague Dawley rats is largely modified. Thyroids present a modified activity which is evidenced by the histological study as well as T4 and T3 assays. In hypophysis, thyrotropic cells were found in an hyperactive state, a fact which is in agreement with the changes observed in thyroid follicles size and epithelial cells demonstrating an hyperactivity of thyroid glands. Despite this histological result, T4 serum level was lowered. T3 level was also decreased but to a lesser extent. We suggest that the low thyroid hormone level play a role in the relative protection of females versus males toward liver cancer induction by chemicals.

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Thyroid activity during hepatocarcinogenesis by N-2-fluorenylacetamide

Stora

Aussel

Lafaurie

et al. 1981

J Cancer Res Clin Oncol

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Immunolocalization of alpha-fetoprotein in the ovary and hypophysis of immature female rats

et al. 1982

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Alpha-fetoprotein (AFP), an oestrogen-binding protein, has been localized in the ovary and hypophysis of prepuberal rats. In the ovary, AFP was localized in secondary follicles, its distribution being limited to the liquor folliculi and the zona pellucida. In the hypophysis, AFP was only found in blood vessels. The intra-ovarian localization of the protein is consistent with our previous hypothesis that AFP might act as a regulator of ovarian activity by decreasing the local free oestradiol level.

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Alpha-fetoprotein and serum hormone levels following liver intoxication with carbon tetrachloride

Aussel

Stora

Krebs

1980

Biochemical and Biophysical Research Communications

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Changes in ovarian activity during hepatocarcinogenesis by n-2-fluorenylacetamide: Role of alpha-fetoprotein

Cited by 7 publications

References 12 publications

Thyroid activity during hepatocarcinogenesis by N-2-fluorenylacetamide

Thyroid activity during hepatocarcinogenesis by N-2-fluorenylacetamide

Immunolocalization of alpha-fetoprotein in the ovary and hypophysis of immature female rats

Alpha-fetoprotein and serum hormone levels following liver intoxication with carbon tetrachloride

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