Immunolocalization of alpha-fetoprotein in the ovary and hypophysis of immature female rats

Castelli, D.; Aussel, Claude; Lafaurie, M.; Ayraud, N; Stora, C

doi:10.1007/bf01005230

Cited by 8 publications

(1 citation statement)

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“…AFP was first proposed and then confirmed to play a blocking role in genital cycling as well as the induction of follicular atreas (68). Prior to that report, AFP had been localized both in the ovary and hypophysis of prepubertal rats (69). During postnatal rat development, it is known that AFP serum levels drop to adult (low) concentrations coincident with achievement of ovarian maturity on Postnatal Day 35, and administration of supplemental AFP alters reproductive events at this time (70).…”

Section: Structural and Functional Aspects Of Afpmentioning

confidence: 98%

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Mizejewski

2007

Exp Biol Med (Maywood)

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The many physiologic roles of human alpha-fetoprotein (HAFP) and its correlation with perinatal distress/pregnancy outcome are rarely addressed together in the biomedical literature, even though HAFP has long been used as a biomarker for fetal birth defects. Although the well being of the fetus can be monitored by the measurement of gestational age-dependent HAFP in biologic fluid levels (serum, amniotic fluid, urine, and vaginal fluids) throughout pregnancy, the majority of clinical reports reflect largely second trimester and (less likely) first trimester testing due to regulatory clinical restrictions. However, reports of third-trimester and pregnancy term measurement of HAFP levels performed in clinical research and/or investigational settings have gradually increased over the years and have expanded our base knowledge of AFP-associated pregnancy disorders during these stages. The different structural forms of HAFP (isoforms, epitopes, molecular variants, etc.) detected in the various biologic fluid compartments have been limited by antibody recognition of specific epitopic sites developed by the kit manufacturers based on antibody specificity, sensitivity, and precision. Concomitantly, the advances in elucidating the various biologic actions of AFP are opening new vistas toward understanding the physiologic roles of AFP during pregnancy. The present review surveys HAFP as a biomarker for fetal distress during the perinatal period in view of its structural and functional properties. An attempt is then made to relate the AFP fluid levels to adverse pregnancy complications and outcomes. Hence, the present review was divided into two major sections: (I) AFP structure and function considerations and (II) the relationship of AFP levels to the distressed fetus during the third trimester and at term.

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Section: Structural and Functional Aspects Of Afpmentioning

confidence: 98%

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Mizejewski

2007

Exp Biol Med (Maywood)

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Immunocytochemical localization of albumin in ovarian follicles of fertile rats

Spanel‐Borowski

1987

Cell Tissue Res.

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The purpose of this study was to investigate whether albumin (Alb) can be detected in ovarian rat granulosa cells. Using immunocytochemistry and morphometrics, the percentages of Alb-positive follicles (follicle-index), of Alb-positive granulosa cells (granulosa-index), and of strongly reacting follicles (intensity-index) were evaluated in intact and regressing follicles of different diameter groups during different stages of the estrous cycle. In intact follicles, the follicle- and the granulosa-index increased from small-sized to large-sized follicles. Although the follicle-index did not change in any group during the stages of the estrous cycle, the granulosa-index was higher during proestrus than during the other stages. Intact follicles showed a stronger immunoreactivity than regressing follicles throughout the stages of the estrous cycle. Thus, Alb may be a requirement for the control of follicle growth in fertile rats. This Alb function may be attributable to Alb binding to specific cell-membrane components followed by the intracellular uptake of Alb-bound substances.

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Pelc¹

2017

Interceram. - Int. Ceram. Rev.

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Immunolocalization of alpha-fetoprotein in the ovary and hypophysis of immature female rats

Cited by 8 publications

References 12 publications

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome

Immunocytochemical localization of albumin in ovarian follicles of fertile rats

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