Alpha-fetoprotein and serum hormone levels following liver intoxication with carbon tetrachloride

Aussel, Claude; Stora, C; Krebs, B

doi:10.1016/0006-291x(80)90857-8

Cited by 8 publications

(3 citation statements)

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“…Thyroid: decreased thyroid hormones thyroxine (T4) and triiodothyronine (T3) in rats (34,(59)(60)(61); progesterone: increased progesterone levels in exposed rats (30)(31)(32)(33) Unknown Decreased ovarian weight and lack of healthy follicles in treated rats (62,63) DDTy (and related compounds)z…”

Section: Methodsmentioning

confidence: 99%

“…carbaryl (16)(17)(18)(19)(20)(21), dichlorodiphenyltrichloroethane (DDT) (22)(23)(24)(25), lindane (25)(26)(27), and mancozeb (28,29) affect the ovary by reducing the number of corpora lutea, disrupting ovarian cyclicity, and increasing the number of follicular cysts. These and other pesticides (carbon tetrachloride (30)(31)(32)(33)(34) and maneb (35,36)) act as reproductive hormone agonists or antagonists in both in vitro and in vivo studies. We examined data from the Agricultural Health Study, a longitudinal study of farmers and their wives residing in Iowa and North Carolina, to determine whether exposure to these specific hormonally active and ovotoxic pesticides was associated with timing of menopause among women between the ages of 35 and 55 years living and working on farms.…”

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confidence: 99%

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Pesticide Exposure and Timing of Menopause

Farr¹,

Cai²,

Savitz³

et al. 2006

American Journal of Epidemiology

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Age at menopause has implications for fertility and risk of hormonally related chronic diseases. Some pesticides disrupt reproductive hormones or are toxic to the ovary, but little is known about the association between pesticide exposure and timing of menopause. Cox proportional hazards modeling was used to examine the association between use of pesticides and age at menopause among 8,038 women living and working on farms in Iowa and North Carolina. Premenopausal women aged 35-55 years were followed from enrollment (1993-1997) to the date of their last menstrual period, or their follow-up interview (1999-2003) if still premenopausal. Women who experienced surgical menopause were censored at the date of surgery. Approximately 62% of the women reported ever mixing or applying pesticides; women who had never used pesticides were the comparison group for all analyses. After control for age, smoking status, and past use of oral contraceptives, the median time to menopause increased by approximately 3 months for women who used pesticides (hazard ratio = 0.87, 95% confidence interval: 0.78, 0.97) and by approximately 5 months for women who used hormonally active pesticides (hazard ratio = 0.77, 95% confidence interval: 0.65, 0.92). Pesticide use may be associated with a later age at menopause.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Pesticide Exposure and Timing of Menopause

Farr¹,

Cai²,

Savitz³

et al. 2006

American Journal of Epidemiology

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“…Expression of AFP is frequently seen during periods of rapid cell growth such as are observed in the developing fetus and in certain tumors. Additionally, certain benign liver abnormalities such as cirrhosis, chronic active hepatitis, or carbon tetrachloride intoxication, in which liver necrosis and subsequent regeneration occur, are also associated with increased production of AFP (Aussel et al, 1980;Vassella et al, 1984;Buamah et al, 1986). The appearance of AFP in these conditions has been assumed to be a cause rather than a n effect of the process.…”

Section: Discussionmentioning

confidence: 99%

Human α‐fetoprotein purified from amniotic fluid enhances growth factor‐mediated cell proliferation in vitro

Keel

Eddy

Cho

et al. 1991

Molecular Reproduction Devel

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Using a primary monolayer culture of porcine granulosa cells (pGC) as an in vitro cell proliferation assay, we have examined the growth-promoting activity of alpha-fetoprotein (AFP) purified from term cord blood and midtrimester amniotic fluid. Increasing concentrations (2.5-20%) of crude human cord blood (CB) increased pGC proliferation, while identical concentrations of crude amniotic fluid (AF) were ineffective. When the cell system was maximally stimulated, AF dose dependently decreased cell proliferation. AFP purified from AF and CB (1.25-5.0 micrograms/ml) was not mitogenic alone, but, in the presence of epidermal growth factor (EGF) + insulin-like growth factor (IGF-I) (10 ng/ml each), AFP dose dependently increased cell proliferation to nearly double that of EGF + IGF-I alone. The response of pGC to the proliferative effects of AF-AFP and CB-AFP were identical at each dose of AFP tested. These results indicate that although crude, pooled midtrimester AF does not display the mitogenic activity seen in cord blood, AFP purified from pooled AF significantly synergizes with growth factors to increase cell proliferation markedly.

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