Changes in Neuroglial Interactions in Nigrostriatal Brain Structures on Modeling of Dopamine System Dysfunction

Воронков, Д. Н.; Khudoerkov, R. M.; Доведова, Е. Л.

doi:10.1007/s11055-014-0027-y

Cited by 3 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In response to the physiological and pathological conditions, structural changes occur in astrocytes, which influence neurons through non-synaptic communication [45][46][47]. This altered neuroglial interaction is the underlying cause of neurodegenerative diseases like PD [48].…”

Section: Changes In Glial Cells In Pdmentioning

confidence: 99%

Biomarkers for Parkinson’s Disease: Recent Advancement

2017

View full text Add to dashboard Cite

As a multi-factorial degenerative disease, Parkinson's disease (PD) leads to tremor, gait rigidity, and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible. Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid, oxidative stress, neuroprotection, and inflammation. Also, biomarkers, alone or in combination, are used in the diagnosis and evolution of PD. This review encompasses various biomarkers available for PD and discusses recent advances in their development.

show abstract

Section: Changes In Glial Cells In Pdmentioning

confidence: 99%

Biomarkers for Parkinson’s Disease: Recent Advancement

2017

View full text Add to dashboard Cite

show abstract

“…[ 53 54 55 ] Altered neuroglial interaction may be the underlying cause for many neurological diseases including PD. [ 56 ] Glial response in PD offers both beneficial and hazardous effects. [ 57 ]…”

Section: Changes In Glial Cells In Parkinson's Diseasementioning

confidence: 99%

Neuroanatomical changes in Parkinson′s disease in relation to cognition: An update

Prakash

Bannur

Chavan

et al. 2016

J Adv Pharm Technol Res

View full text Add to dashboard Cite

The pathophysiological changes underlying impairment of cognition in Parkinson's disease (PD) are complex and not fully understood till date. Hence, understanding the structural changes responsible for cognitive decline in PD is essential for early diagnosis and to offer effective treatment. In this review, we discuss the neuroanatomical changes in major brain structures responsible for cognition in PD. We have included the key findings of various studies to provide up-to-date information for better understanding of pathophysiology of PD, which will help researchers and clinicians in planning and developing new treatment methods for the benefit of PD patients.

show abstract

“…Against the background of taking AP, synaptic denervation occurs due to a calcium-dependent depolymerization of microtubules in motor neurons [ 97 ]. It also increases the activity of glia and cells, leading to inflammation [ 98 , 99 ]. Motor ADR in the presence of APs may be the result of antagonism of D2 type dopamine receptors, resulting in the induction of oxidative stress and increased production of free radicals (ROS) [ 100 ] due to which the concentration of calcium ions increases both intracellularly and extracellularly [ 101 , 102 ].…”

Section: Introductionmentioning

confidence: 99%

Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism

et al. 2022

View full text Add to dashboard Cite

Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.

show abstract

Changes in Neuroglial Interactions in Nigrostriatal Brain Structures on Modeling of Dopamine System Dysfunction

Cited by 3 publications

References 6 publications

Biomarkers for Parkinson’s Disease: Recent Advancement

Biomarkers for Parkinson’s Disease: Recent Advancement

Neuroanatomical changes in Parkinson′s disease in relation to cognition: An update

Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism

Contact Info

Product

Resources

About