Changes in Interleukin 18 in the Retinas of Otsuka Long-Evans Tokushima Fatty Rats, a Model of Human Type 2 Diabetes

Nagai, Noriaki; Ito, Yoshimasa; Okamoto, Norio; Shimomura, Yoshikazu; Okamura, Haruki

doi:10.5650/jos.62.513

Cited by 4 publications

(2 citation statements)

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“…We observed that in type 2 diabetic rats, which demonstrated insulin resistance, the level of IL-18 was significantly lower than in control healthy rats. Our results contradict the studies describing the elevated level of IL-18 in the Otsuka Long-Evans Tokushima Fatty rats and fructose-fed rats [75,76]. These differences may result from sexual dimorphism, as these studies were conducted on male rats [75,76] and not on female rats.…”

Section: Discussioncontrasting

confidence: 99%

“…Our results contradict the studies describing the elevated level of IL-18 in the Otsuka Long-Evans Tokushima Fatty rats and fructose-fed rats [75,76]. These differences may result from sexual dimorphism, as these studies were conducted on male rats [75,76] and not on female rats. Such gender discrepancies in the plasma IL-18 level were previously observed in wild-type mice injected intraperitoneally with LPS [77].…”

Section: Discussioncontrasting

confidence: 99%

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Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female Rats

et al. 2019

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Cardiovascular diseases are one of the most common complications of type 2 diabetes. They are considered the leading cause of death among diabetics. One of the mechanisms underlying diabetic cardiovascular complications is oxidative stress. Many phenolic acids are regarded as antioxidants. The aim of the study was to investigate the effect of rosmarinic acid (RA) and sinapic acid (SA) on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Additionally, the effect of these compounds on glucose homeostasis and lipid profile in the serum was evaluated. Type 2 diabetes was induced with high-fat diet and streptozotocin. RA at the doses of 10 and 50 mg/kg and SA at the doses of 5 and 25 mg/kg were administrated orally for 28 days. Untreated diabetic rats exhibited unfavorable changes in glucose metabolism and lipid profile. Changes in the enzymatic and non-enzymatic markers indicated the onset of oxidative stress in these animals. The results showed that the higher doses of the tested phenolic acids—50 mg/kg of RA and 25 mg/kg of SA—revealed beneficial effects on oxidative stress in the cardiac tissue of diabetic rats.

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