Interleukin-18 and testosterone levels in men with metabolic syndrome

Angelova, Petya; Kamenov, Zdravko; Tsakova, Adelina; El‐Darawish, Yosif; Okamura, Haruki

doi:10.1080/13685538.2017.1401993

Cited by 18 publications

(9 citation statements)

References 57 publications

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“…In our study, we draw a conclusion that both obese men and metabolic unhealthy men had a higher risk of developing low serum TT levels than normal weight and metabolic healthy individuals, which is consistent with the results in previous study [8][9][10][11]13]. It demonstrated that serum TT levels in male population were associated with BMI and different components of metabolic syndrome.…”

Section: Discussionsupporting

confidence: 92%

“…The prevalence of metabolic syndrome ranges from 10 to 34 percent according to different de nitions or populations [7]. Several studies have pointed that metabolic syndrome can be regarded as an independent association with low levels of total testosterone in male population [8][9][10][11]. And low levels TT and SHBG can be considered as independent risk factors for metabolic syndrome [12][13].…”

Section: Introductionmentioning

confidence: 99%

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Association of Metabolic Obesity Phenotypes and Total Testosterone in Middle-aged and Elderly Male Population

Guan¹,

Liu²,

S³

et al. 2020

Preprint

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Objectives Obesity and metabolic syndrome have been reported to exert an impact on male reproductive system with decreasing levels of serum total testosterone (TT), however, the effect of different metabolic obesity phenotypes on testosterone has been poorly studied. We aimed to evaluate the association of metabolic obesity phenotypes and total testosterone levels in male population. Methods We performed a retrospective study based on an epidemiological investigation, a total of 4 081 middle-aged and elderly male individuals were recruited. The population was classified as metabolically healthy normal weight (MHNW); metabolically healthy obese (MHO); metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO) according to normal weight (BMI<25.0) and obesity (BMI≥25.0) with or without metabolic syndrome. Results We collected 563 hypotestosteronemia among 4 081 middle-aged and elderly male individuals. The odds ratios (ORs) (95% CIs) of hypotestosteronemia in obesity and metabolic syndrome was 3.072 (2.414-3.911) and 3.294 (2.631-4.125) respectively, after adjusting for age, luteinizing hormone, smoking status and alcohol consumption. Compared to MHNW group, male subjects in MHO, MUNW and MUO groups had a decreased serum TT levels. Additionally, MUO group have a lowest concentration of serum TT and a highest proportion of hypotestosteronemia. There was no significant difference of TT levels between MHO and MUNW group. Conclusions Obesity and metabolic syndrome are independent risk factor of hypotestosteronemia in middle-aged and elderly male populations. Our study also suggested that individuals with MHO, MUNW and MUO have a higher risk of developing hypotestosteronemia.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association of Metabolic Obesity Phenotypes and Total Testosterone in Middle-aged and Elderly Male Population

Guan¹,

Liu²,

S³

et al. 2020

Preprint

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“…Like other pro-inflammatory cytokines (such as IL-1β, TNFα, interleukin 6 (IL-6) ( 13 , 14 , 15 , 16 ) and high-sensitivity C-reactive protein (hs-CRP) ( 17 )), elevated IL-18 level is a characteristic of obesity and the metabolic syndrome ( 18 , 19 , 20 ), and is reduced by weight loss ( 19 , 21 ). The presence of the metabolic syndrome is associated with even higher IL-18 concentration than obesity alone, as has been shown for IL-6, TNFα and CRP ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

Zaharieva¹,

Kamenov²,

Velikova

et al. 2018

Endocrine Connections

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BackgroundInterleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects.Materials and methodsIL-18 was analyzed through enzyme-linked immunosorbent assay in 76 participants with T2D and 24 with LADA and 14 control subjects. Evaluation was also carried out in body mass index (BMI)- and glycemic control-matched diabetic patients.ResultsThe serum concentration of IL-18 was higher in patients with T2D (389.04 ± 203.44 pg/mL) and LADA (327.04 ± 144.48 pg/mL) than that in control subjects (219.88 ± 91.03 pg/mL), P < 0.05. However, it was not significantly different between both diabetic groups (P = 0.255) despite higher IL-6 (4.78 ± 5.84 vs 1.79 ± 0.96 pg/mL, P < 0.001) and hs-CRP (2.60 ± 1.70 vs 1.29 ± 1.20 mg/L, P = 0.002) level in T2D patients. The results were persistent in BMI-matched subjects with diabetes (IL-18 = 403.48 ± 226.32 vs 329.30 ± 146.30 pg/mL, respectively for T2D and LADA, P = 0.391). The correlations in T2D group concerning HDL cholesterol (r = −0.377, P = 0.001), postprandial glucose (r = 0.244, P = 0.043), IL-6 (r = 0.398, P < 0.001) and hs-CRP (r = 0.427, P = 0.001) were not confirmed in LADA and control subjects.ConclusionThe IL-18 serum level was higher in T2D and LADA than that in control subjects, but did not differ between both diabetic groups, even when they were BMI matched. Correlations with lipid, glycemic and inflammatory parameters were present in T2D only.

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“…In our study, we draw a conclusion that both overweight/obese men and metabolic unhealthy men had a higher risk of developing low serum TT levels than normal weight and metabolic healthy individuals, which is consistent with the results in previous studies. [8][9][10][11]13 It demonstrated that serum TT levels in the male population were associated with BMI and different components of metabolic syndrome. A Korean study has shown that serum TT levels were negatively associated with BMI, WC, FPG, TG, and blood pressure, and positively associated with HDL-L levels.…”

Section: Discussionmentioning

confidence: 99%

“…7 Several studies have pointed that metabolic syndrome can be regarded as an independent association with low levels of total testosterone in males. [8][9][10][11] And low levels of TT and SHBG can be considered as independent risk factors for metabolic syndrome. 12,13 However, the relationship of TT with metabolic syndrome remains inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association of Metabolic Obesity Phenotypes and Total Testosterone in Chinese Male Population

Liu

Song

et al. 2021

DMSO

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Objective Obesity and metabolic syndrome have been reported to exert an impact on the male reproductive system with decreasing levels of serum total testosterone (TT); however, the effect of different metabolic obesity phenotypes on testosterone has been poorly studied. We aimed to evaluate the association of metabolic obesity phenotypes and total testosterone levels in a Chinese male population. Methods We performed a retrospective study based on an epidemiological investigation, a total of 4,081 male individuals aged from 40–75 years old were recruited. The population was classified as metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO) according to normal weight (BMI<25.0) and overweight/obesity (BMI≥25.0) with or without metabolic syndrome. Results We collected 563 hypotestosteronemia among 4,081 male individuals. The odds ratios (ORs) (95% CIs) of hypotestosteronemia in obesity and metabolic syndrome were 3.072 (2.414–3.911) and 3.294 (2.631–4.125), respectively, after adjusting for age, luteinizing hormone, smoking status, and alcohol consumption. Compared to the MHNW group, male subjects in MHO, MUNW, and MUO groups had decreased serum TT levels. Additionally, the MUO group had a lowest concentration of serum TT and a highest proportion of hypotestosteronemia. There was no significant difference of TT levels between the MHO and MUNW groups. Conclusion Obesity and metabolic syndrome are independent risk factors of hypotestosteronemia in Chinese male populations. Our study also suggested that individuals with MHO, MUNW, and MUO have a higher risk of developing hypotestosteronemia.

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Interleukin-18 and testosterone levels in men with metabolic syndrome

Abstract: In this study, higher IL-18 levels were found in the presence of MS compared to healthy men, but they did not differ between men having MS with or without LOH.

Cited by 18 publications

References 57 publications

Association of Metabolic Obesity Phenotypes and Total Testosterone in Middle-aged and Elderly Male Population

Association of Metabolic Obesity Phenotypes and Total Testosterone in Middle-aged and Elderly Male Population

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

Association of Metabolic Obesity Phenotypes and Total Testosterone in Chinese Male Population

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