Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000‐2016 in the Stockholm region and Sweden

Haeggblom, Linnea; Attoff, Tove; Yu, Jingru; Holzhauser, Stefan; Vlastos, Andrea; Mirzae, Leila; Ährlund‐Richter, Andreas; Munck‐Wikland, Eva; Marklund, Linda; Hammarstedt‐Nordenvall, Lalle; Ye, Weimin; Ramqvist, Torbjörn; Näsman, Anders; Dalianis, Tina

doi:10.1002/hed.25585

Cited by 71 publications

(75 citation statements)

References 45 publications

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“…Human papillomavirus positive (HPV + ) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) generally have a better outcome than the corresponding HPV negative (HPV -) cancers and most other head neck squamous cell carcinoma (HNSCC), and their incidences have increased considerably (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Most HPV + TSCC/BOTSCC patients do therefore not need the intensified treatment, more recently given to HNSCC patients in general, and which has not improved survival for patients with HPV + TSCC/BOTSCC (5,(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

In�vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines

et al. 2019

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Human papillomavirus positive (HPV + ) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have better outcomes than corresponding HPVnegative (HPV -) cancer cases. Our previous study demonstrated that fibroblast growth factor receptor 3 (FGFR3) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a (PIK3CA) are often mutated in HPV + cancer. To investigate whether targeted therapy is an option for TSCC/BOTSCC, two HPV + and one HPV -TSCC/BOTSCC cell lines were tested for their sensitivity towards FGFR and PI3K inhibitors. The HPV + cell lines UM-SCC-47 and UPCI-SCC-154, and the HPVcell line UT-SSC-60A were tested by competitive allele-specific TaqMan-PCR for presence/absence of frequently occurring FGFR3 and PIK3CA mutations. All cells were then treated with FGFR inhibitor AZD4547 and PI3K inhibitors BEZ235 and BKM120 alone, or with AZD4547 and BEZ235 in combination. Viability was analyzed using a WST-1 assay, cytotoxicity tested by a CellTox Green cytotoxicity assay, apoptosis analyzed by a Caspase Glo 3/7 assay and proliferation examined with the xCELLigence system. HPV + UM-SCC-47 and UPCI-SCC-154 cells, and HPV -UT-SSC-60A cells, did not exhibit any common FGFR3 or PIK3CA mutations, but were all sensitive to FGFR inhibitor AZD4547 and PI3K inhibitors BEZ235 and BKM120. Notably, HPV + UPCI-SCC-154 cells were more sensitive than the other two cell lines. Furthermore, when AZD4547 and BEZ235 treatment was combined in HPV + UPCI-SCC-154 and HPV -UT-SSC-60A cells, potentiated combination effects were observed. HPV + UM-SCC-47 and UPCI-SCC-154 cells, and HPV -UT-SSC-60A cells had no common FGFR3 or PIK3CA mutations, but were sensitive to FGFR inhibitor AZD4547, and PI3K inhibitors BEZ235 and BKM120. Furthermore, the latter two cell lines were particularly sensitive to combinations of AZD4547 and BEZ235.

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Section: Introductionmentioning

confidence: 99%

In�vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines

et al. 2019

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“…The comparability of tongue cancer to mouth cancer could be alarming if it will be interpreted as health-seeking behavior due to new cases. This is comparable to the global increase in tongue cancer in developing (Cohen Goldemberg et al, 2018) and developed nations (Haeggblom et al, 2019). This cannot be verified by the data provided by the Philippines cancer registries as all types of oral cancer are grouped into one.…”

Section: Discussionmentioning

confidence: 70%

Analysis of the Filipinos’ Interest in Searching Online for Oral Cancer

Dalanon

Esguerra

Diano

et al. 2020

Asian Pac J Cancer Prev

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Objective: This study analyzed the health-seeking behavior of Filipinos through relative search volume in Google Trends using oral cancer, mouth cancer, tongue cancer, gum cancer, and lip cancer as predetermined search terms. Methods: Comma-separated values files containing relative search volumes of search trends pertaining to oral cancer from 2009 to 2019 were assessed. Brown-Forsythe one-way ANOVA was used to measure differences of oral cancer between years and among months. Repeated measures two-way ANOVA measured differences among the searches for mouth cancer, tongue cancer, gum cancer, and lip cancer through the years. Time series models were fitted and used to forecast search interests. Results: The results revealed that interests in oral cancer were significantly higher in 2019 (43.75±5.5, p<0.05) compared to 2009 (29.0 ± 6.7). In terms of months, searches were higher in February (45.0 ± 6.6) compared to May (24.8 ± 3.4, p=0.015), June (25.3 ± 4.4, p=0.020), and December (26.5 ± 4.0, p=0.038). Search interests for gum cancer and lip cancer remained significantly lower from 2011 to 2019, and tongue cancer from 2016 to 2018 but approximated mouth cancer in 2019. The forecast shows mouth cancer (31.67%), tongue cancer (23.75%), and lip cancer (3.83%) fluctuating through the year, while gum cancer (8%) will remain steady in 2020. Conclusion: Health-seeking behavior through search trends show an increased interest in oral cancer in 2019 and during February. Search interests will fluctuate in 2020, but at the end of the year will decrease for mouth cancer and tongue cancer, will increase for lip cancer, and will remain steady for gum cancer.

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“…3 HPV-16 plays a major role and indeed is responsible for >80% of HPV-associated OPCs. 4 The high HPV-attributable fraction, together with the rapid increase in the incidence of HPV-related OPC in several western countries, [5][6][7][8] means that interventions for the prevention of these tumors are of particular importance. Although the efficacy of the available HPV vaccines in preventing oral infection has been demonstrated, [9][10][11][12] and even a herd effect in men has been reported, 13 the vaccine has yet to be approved for the prevention of HPV-associated OPC.…”

Section: Introductionmentioning

confidence: 99%

Abnormal cytology in oropharyngeal brushings and in oral rinses is not associated with HPV infection: The OHMAR study

Benevolo

Rollo

Giuliani

et al. 2020

Cancer Cytopathology

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Background No screening is available for human papillomavirus (HPV)‐associated oropharyngeal cancers. The authors investigated whether cytology may be used as a screening tool and whether oral HPV infection is associated with cytologic abnormalities detected in oropharyngeal brushings and in oral rinse‐and‐gargle specimens from asymptomatic individuals at increased risk for oral HPV infection. Methods Specimens were collected from men who have sex with men at 6‐month intervals. Oropharyngeal samples and oral rinse‐and‐gargle specimens were collected using a cytobrush and mouthwash, respectively. Exfoliated cells were dispersed in PreservCyt. Liquid‐based slides were stained with Papanicolaou. An HPV genotyping test using a linear array was used for HPV detection. Associations with abnormal cytology were investigated using logistic regression. Results Overall, 631 brushings and 802 rinses collected from 310 individuals were evaluated; of these specimens, 2 brushings (0.3%) and 10 rinses (1.2%) were inadequate for morphologic evaluation. Of the adequate samples, 35 of 629 brushings (5.5%) and 19 of 792 rinses (2.4%) were abnormal. No associations of high‐risk HPVs or HPV‐16 infection with cytologic abnormalities were observed for oropharyngeal brushings (high‐risk HPVs: odds ratio [OR], 1.19; 95% CI, 0.41‐3.50; P = .75; HPV‐16: OR, 0.76; 95% CI, 0.10‐5.84; P = .79) or for oral rinses (high‐risk HPVs: OR, 1.13; 95% CI, 0.26‐4.98; P = .87; HPV‐16: OR, 0.62; 95% CI, 0.04‐10.60; P = .74). Concurrent moderate/heavy drinking and smoking significantly increased the risk of cytologic abnormalities in the brushings (hazard ratio, 4.84; 95% CI, 1.15‐20.43; P = .03). Conclusions Oral HPV infection by high‐risk HPVs and HPV‐16 does not confer an increased risk of cytologic abnormalities in oropharyngeal brushings and oral rinses. Abnormal cytology seems to be associated with smoking and drinking habits.

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Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000‐2016 in the Stockholm region and Sweden

Cited by 71 publications

References 45 publications

In�vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines

In�vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines

Analysis of the Filipinos’ Interest in Searching Online for Oral Cancer

Abnormal cytology in oropharyngeal brushings and in oral rinses is not associated with HPV infection: The OHMAR study

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