Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus

Park, Jong Chul; Han, Won Dong; Park, Jeong Ro; Choi, Seong Hee; Choi, Jong Won

doi:10.1016/j.jep.2005.06.023

Cited by 32 publications

(15 citation statements)

References 18 publications

(14 reference statements)

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“…However, gallic acid treatment significantly reversed these changes in mice. The inhibitory activity of gallic acid on free radical production could be due to its action on cytochrome P450‐dependent mono‐oxygenase activities and the enhancement of epoxide hydrolase activity [32,33] . Moreover, the free radical scavenging action of gallic acid is already well established from earlier investigations [10,11] …”

Section: Discussionmentioning

confidence: 93%

Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

Rasool

Sabina

Ramya

et al. 2010

Journal of Pharmacy and Pharmacology

146

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Section: Discussionmentioning

confidence: 93%

Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

Rasool

Sabina

Ramya

et al. 2010

Journal of Pharmacy and Pharmacology

146

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“…Orostachys japonicus (Crassulaceae), a perennial herb employed as a medicinal plant, has been used as a folk treatment for inflammatory, febrile, hemostatic, antidote, and variable cancers (Park, Han, Park, Choi, & Choi, 2005; Ryu, Lee, Lee, & Lee, 2012). Orostachys japonicus is reported to contain 16 types of flavonoid contents.…”

Section: Introductionmentioning

confidence: 99%

Orostachys japonicus induce p53‐dependent cell cycle arrest through the MAPK signaling pathway in OVCAR‐3 human ovarian cancer cells

Lee

Kim

Lee

2018

Food Science & Nutrition

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Orostachys japonicus (O. japonicus) is utilized as a traditional medicine for patients with various diseases. This study investigated the effect of the ethyl acetate fraction from O. japonicus extract (OJE) on the growth inhibition of OVCAR‐3 human ovarian cancer cells demonstrated to inhibit cell growth and arrest the cell cycle in OVCAR‐3 cells by blocking the sub‐G1 phase and decreasing cyclin E1/CDK2 expression. Cell cycle arrest was connected to the increased expression of the cell cycle regulating factors p53 and p21. Apoptosis was initiated through the intrinsic pathway by up‐regulating the expression of the Bcl‐2/Bax ratio and down‐regulating the expression of pro‐caspase‐3. Furthermore, OJE treatment elicited p‐p38 activation and p‐ERK1/2 inhibition. In conclusion, our results demonstrated that OJE reduced the growth of OVCAR‐3 human ovarian cancer cells mediated by arrest of the cell cycle and regulation of MAPK signaling pathways.

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“…Orostachys japonicus A. Berger (Crassulaceae), also referred to as Wa-song in Korea, is a perennial herb and a medicinal plant (7). It has been traditionally used as a general anti-inflammatory remedy to treat hepatitis, boils, and hemorrhoids; as a hemostatic agent to treat hematemesis, epistaxis, and hematochezia; and as an anti-cancer remedy (8).…”

Section: Introductionmentioning

confidence: 99%

Anti-oxidizing effect of the dichloromethane and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling pathway

Lee

Kim

et al. 2014

BMB Reports

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Orostachys japonicus shows various biological activities. However, the molecular mechanisms remain unknown in LPS-stimulated macrophages. Here, we investigated the anti-oxidizing effect of the dichloromethane (DCM) and hexane fractions from O. japonicus (OJD and OJH) against oxidative stress in RAW 264.7 cells stimulated by LPS. OJD and OJH significantly increased the expression of heme oxygenase-1 (HO-1) in a dose- and time-dependent manner. Additionally, it was found that the expression of HO-1 was stimulated by Nrf2 activated via degradation of Keap1. ERK and p38 inhibitors repressed HO-1 induced by OJD and OJH in LPS-stimulated cells, respectively. In conclusion, these results suggest that OJD and OJH may block oxidative damage stimulated by LPS, via increasing the expression of HO-1 and Nrf2, and MAPK signaling pathway. [BMB Reports 2014; 47(2): 98-103]

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Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus

Cited by 32 publications

References 18 publications

Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

Orostachys japonicus induce p53‐dependent cell cycle arrest through the MAPK signaling pathway in OVCAR‐3 human ovarian cancer cells

Anti-oxidizing effect of the dichloromethane and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling pathway

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