Changes in Gastric Acidity in Peptic Ulcer, Cholecystitis and Other Diseases

Vanzant, Frances R.; Alvarez, Walter C.; Berkson, Joseph; Eusterman, George B.

doi:10.1001/archinte.1933.00160040122007

Cited by 47 publications

(4 citation statements)

References 6 publications

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“…In Table 3 are shown the percentages of men and women whose gastric contents did not contain free hydrochloric acid and the mean free acidity of the gastric contents of the remaining men and women, both for this series of small gastric cancer and for a series of gastric cancer of all sizes ; also shown are the differences of each from the cor¬ responding values for normal persons of the same age and sex. 4 These data show that gastric secretory activity in small gastric cancer is below normal but much nearer normal than in gastric cancer of all sizes.…”

Section: Relation Of Type To Duration Of Symptomsmentioning

confidence: 71%

Small Gastric Cancer

Comfort¹

1954

Arch Intern Med

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A GASTRIC cancer of small size always arouses the hope that it is more amenable to therapy and possesses a better prognosis than gastric cancer in general. Do the facts justify this hope? Does the small gastric cancer differ in any way from gastric cancers of all sizes ? Can it be removed more safely ? Are survival rates better for small cancers ? Analysis of records of a group of small gastric cancers has in general provided affirmative answers to these questions. MATERIALDuring the years 1940 to 1945, inclusive, 924 adenocarcinomas of the stomach were treated by gastric resection at the Mayo Clinic. In 226 of these, the greatest diameter measured 4 cm. or less. Thus, gastric cancer of this size accounts for about one quarter of all gastric cancer treated by resection. The importance of this group in the over-all survival rate of patients with gastric cancer is obvious.For purposes of study, these 226 small gastric cancers were subdivided according to size into four smaller groups, thus providing data about cancers of varying degrees of smallness. The greatest diameter measured 1.0 cm. or less in 18 cases (8%), from 1.1 to 2.0 cm. in 49 (21.7%), from 2,1 to 3.0 cm. in 67 (29.6%), and from 3.1 to 4.0 cm. in 92 (40.7%) of the 226 cases. Lymphosarcomas were excluded from the study so that survival rates would pertain only to adenocarcinomas.

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Section: Relation Of Type To Duration Of Symptomsmentioning

confidence: 71%

Small Gastric Cancer

Comfort¹

1954

Arch Intern Med

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“…In patients with ulcer, free hydrochloric acid has been generally found to be present in increased quantities (1,2). The work of Dragstedt (3) and of Mann and Bollman (4) have tended to emphasize the importance of hydrochloric acid.…”

Section: Introductionmentioning

confidence: 99%

The Role of Pepsin, Peptic Inhibitory Substances, and Hydrochloric Acid in Normal Subjects and in the Production of Peptic Ulcers 1

Veen¹,

Hallinger²

1947

J. Clin. Invest.

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“…However, we are no closer to an explanation than Hollander's [1] proposal that an ulcer is the result of an imbalance between the diges tive action of acid-pepsin and mucosal de fences. This general statement of the problem can only be regarded as a preliminary to the full explanation of why, for example, gastric ulcers are associated with hypoacidity [2] and occur in non-acid-secreting mucosa [3] or why hypersecretion of acid produces duode nal ulcers [4], We appear to be even further away from an explanation of why ulcers usually occur singly and as rounded, welldemarcated lesions which involve the full thickness of the gut wall. Details are available on secretory' alterations but there is a paucity of information on mucosal defence mecha nisms.…”

mentioning

confidence: 99%

The Possible Role of Bicarbonate in Mucosal Protection and Peptic Ulceration

Vadgama¹,

Alberti²

1983

Digestion

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The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust mucus pH to a range at which this barrier property is optimized. It is further proposed that a high content of luminal bicarbonate will promote the transfer of protons across mucus by a buffer shuttle mechanism, and that this may be the basis for the development of peptic ulceration.

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Changes in Gastric Acidity in Peptic Ulcer, Cholecystitis and Other Diseases

Cited by 47 publications

References 6 publications

Small Gastric Cancer

Small Gastric Cancer

The Role of Pepsin, Peptic Inhibitory Substances, and Hydrochloric Acid in Normal Subjects and in the Production of Peptic Ulcers 1

The Possible Role of Bicarbonate in Mucosal Protection and Peptic Ulceration

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