WVE WISH TO REPORT A CASE in which complete pancreatectomy was performed for hyperinsulinism due to a small islet-cell adenoma located in the head of the pancreas near the duodenum. The case has several interesting features justifying its report. It is probably the second or third total pancreatectomy, and the first reported case known to us of complete pancreatectomy with survival following operation for more than a few weeks. It is the first total pancreatectomy for a benign lesion of the pancreas. The adenoma discovered in the removed pancreas is one of the smallest functioning isletcell tumors reported, if not the smallest. Most important is the fact that the patient is living and well at the time that this paper is written, I6 months after the operation. Observations on the resulting diabetes and digestive disturbances are recorded.
CASE REPORTThe patient, a Jewish woman, age 49, registered at the Mayo Clinic July 6, I942. She complained of fainting spells which had occurred intermittently during the previous three years. There were several different types of attacks, consisting of unconsciousness, dizziness, blank spells and sweating spells, all of which had been relieved by the administration of carbohydrate varying from orange juice to intravenously injected glucose. During one of the patient's unconscious spells, her physician had obtained a concentration of sugar that was less than 30 mg. per IOO cc. of blood. There had been five severe attacks of unconsciousness lasting from one to five hours. The minor attacks were more frequent than those of more severe character, and varied from dizzy or blank spells to attacks of sweating. These lasted from five minutes to one hour. During the blank spells the patient would feel rather foolish and be somewhat confused. Sweating spells would occur almost every day between TO A.M. and I2 M. They were characterized by drenching perspiration, weakness and slight confusion followed by nausea. * Since this article was written, Doctor Priestley has been commissioned Lieut.Colonel in the Army of the United States. 211
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