Changes in cytokine levels during admission and mortality in acute alcoholic hepatitis

González‐Reimers, Emilio; Sánchez-Pérez, María José; Santolaria-Fernández, F.; Abreu-González, Pedro; Vega-Prieto, Marı́a José de la; Viña-Rodríguez, J.; Alemán-Valls, María Remedios; Rodrı́guez-Gaspar, Melchor

doi:10.1016/j.alcohol.2011.10.001

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…A wide range of cytokines were assessed in samples of ALD patients. These include tumor necrosis factor (TNF)-α, various interleukins (IL) such as IL-1β, IL-4, IL-6, IL-10, and IL-12, and interferon (IFN)-γ, as well as high-sensitivity C-reactive protein (hsCRP), as described in Table 1 [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Several studies have uncovered relationships between cytokine levels and the severity of the disease, as well as the presence of co-morbidities.…”

Section: Alcohol and Cytokinesmentioning

confidence: 99%

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Alcoholic Liver Disease: Role of Cytokines

et al. 2015

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The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters the portal circulation, and is recognized by macrophages (Kupffer cells) and hepatocytes. In individuals with ALD, excessive levels of LPS in the liver affect immune, parenchymal, and non-immune cells, which in turn release various inflammatory cytokines and recruit neutrophils and other inflammatory cells. In this review, we elucidate the mechanisms by which alcohol contributes to the activation of Kupffer cells and the inflammatory cascade. The role of the stellate cells in fibrogenesis is also discussed.

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Section: Alcohol and Cytokinesmentioning

confidence: 99%

“…Table 1 summarizes levels of pro-inflammatory markers in ALD patients [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Alcohol and Cytokinesmentioning

confidence: 99%

Alcoholic Liver Disease: Role of Cytokines

et al. 2015

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“…Importantly, this increase is tightly related to the metabolic injuries in the liver due to ethanol intake. 16,24 More recently, Gonz alesReimers et al 25 found no difference in the plasma concentrations of IL-6 in stable alcoholic patients. Similarly, the absence of hepatic lesions observed in ethanol-preferring animals may be linked to the circulating levels of this cytokine.…”

Section: Discussionmentioning

confidence: 97%

Testosterone Therapy Differently Regulates the Anti‐ and Pro‐Inflammatory Cytokines in the Plasma and Prostate of Rats Submitted to Chronic Ethanol Consumption (UChB)

Mendes

Scarano

Rochel-Maia³

et al. 2014

American J Rep Immunol

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“…Serum IL-8 and IL-12 concentration in patients of AH indirectly reveals information about the degree of liver cell damage as indicated by significant correlation with serum bilirubin and INR. There were many studies done in the past, regarding the serum IL-8 and -12 levels in ALD [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Most of the studies have showed a positive correlation between various forms of ALD like steatosis, alcoholic cirrhosis, AH, and interleukin levels.…”

Section: Discussionmentioning

confidence: 98%

“…There were few studies done in the past which showed the correlation between serum IL-8 and -12 levels with various stages of ALD [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. However, there is no study correlating the serum interleukin levels (8 and 12) with the severity of AH (mild or severe in particular) and mortality in these patients.…”

Section: Introductionmentioning

confidence: 96%