Serum interleukin 8 and 12 levels predict severity and mortality in patients with alcoholic hepatitis

Patel, Onkar; Noor, Mohd Talha; Kumar, Ravindra; Thakur, Bhagwan Singh

doi:10.1007/s12664-015-0565-4

Cited by 10 publications

(13 citation statements)

References 29 publications

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“…After review of titles and abstracts, 71 records were relevant and full text manuscripts were obtained and reviewed. Survival data for patients with nonsevere alcoholic hepatitis were reported in 25 manuscripts (Figure ) . Additional data from a further four studies were requested by email from the corresponding authors.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, multivariable meta‐regression was not appropriate. Selection bias is likely as at least three studies included only male subjects …”

Section: Discussionmentioning

confidence: 99%

“…Selection bias is likely as at least three studies included only male subjects. 37,41,48 Given the clinical and research emphasis on severe alcoholic hepatitis only, patient selection bias and reporting bias are likely.…”

Section: Discussionmentioning

confidence: 99%

“…Survival data for patients with nonsevere alcoholic hepatitis were reported in 25 manuscripts ( Figure 1). 5,[11][12][13][14][15][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] Additional data from a further four studies were requested by email from the corresponding authors. One response was received but no additional data were available for that study.…”

Section: Re Sultsmentioning

confidence: 99%

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Systematic review with meta‐analysis: high mortality in patients with non‐severe alcoholic hepatitis

Bennett

Enki

Thursz

et al. 2019

Aliment Pharmacol Ther

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Summary Background Alcoholic hepatitis is a serious complication of alcohol misuse. Severe alcoholic hepatitis with its high mortality, has been investigated in detail but ‘nonsevere alcoholic hepatitis’ is poorly characterised. Survival of this group of patients is unknown. Aim To conduct a systematic review and meta‐analysis to determine 28‐day, 90‐day and 1‐year mortality of patients with nonsevere alcoholic hepatitis. Methods The protocol was registered on the PROSPERO database (CRD42018107451). Embase, Medline and Cochrane Central databases were searched until July 2018. All study designs reporting mortality rates in patients with nonsevere alcoholic hepatitis were eligible. Mortality data were extracted and meta‐analysis performed using a random effects model. Risk of bias was assessed by Cochrane risk of bias or National Institutes of Health quality assessment tool for case series studies. Results Twenty‐five studies (n = 1372 patients; 12 prospective) met criteria. Nonsevere was variably defined based on bilirubin, prothrombin time, and creatinine. Twenty‐eight day mortality (17 studies; n = 993) was 6% (95% CI 3%‐9%; I2 = 67.3%; P < 0.001), 90‐day mortality (15 studies; n = 755) was 7% (4%‐11%, I2 = 64.2%; P < 0.001) and 1‐year mortality (five studies; n = 234) was 13% (4%‐24%; I2 = 72%; P = 0.006). Subgroup analyses by method of diagnosis (histological vs clinical) or study design (prospective vs retrospective) did not reveal differences in mortality. Conclusion Nonsevere alcoholic hepatitis is not benign with 6% and 13% 28‐day and 1‐year mortality, respectively. This systematic review demonstrates the paucity of high quality studies in patients with nonsevere alcoholic hepatitis. Our analysis suggests that patients who do not meet criteria for severe alcoholic hepatitis are an important and hitherto overlooked clinical group. Full characterisation of clinical outcome and development of treatment strategies to reduce mortality in this group is a priority.

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Section: Resultsmentioning

confidence: 99%

“…Thus, multivariable meta‐regression was not appropriate. Selection bias is likely as at least three studies included only male subjects …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review with meta‐analysis: high mortality in patients with non‐severe alcoholic hepatitis

Bennett

Enki

Thursz

et al. 2019

Aliment Pharmacol Ther

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“…IL-8 and CXCL1/GROα are the two most important chemokines for neutrophil recruitment. Serum and hepatic levels of IL-8 and CXCL1/GROα are elevated in AH patients, and correlate with hepatic neutrophils infiltration, disease severity and mortality (Dominguez et al, 2009;Maltby et al, 1996; Patel et al, 2015; Sheron et al, 1993). Patients with alcoholic cirrhosis have increased frequency of the rs4074 A allele and enhanced CXCL1 serum levels, indicating the CXCL1 rs4074 A allele as a genetic risk factor for alcoholic cirrhosis (Nischalke et al, 2013).…”

Section: Pro-inflammatory Cytokines and Chemokinesmentioning

confidence: 99%

Targeting inflammation for the treatment of alcoholic liver disease

Zhou

Parker

et al. 2017

Pharmacology & Therapeutics

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Alcoholic liver disease (ALD) is a leading cause of chronic liver disease with a wide spectrum of manifestations including simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Liver injury in ALD is caused by chronic inflammation, which has been actively investigated as a therapeutic target for the treatment of ALD for over the last four decades. In this review, we summarize a wide variety of inflammatory mediators that have been shown to contribute to the pathogenesis of ALD, and discuss the therapeutic potential of these mediators for the treatment of ALD.

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Prevention and Management of Alcoholic Liver Disease

Singal¹,

Shah²

2018

Zakim and Boyer's Hepatology

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Serum interleukin 8 and 12 levels predict severity and mortality in patients with alcoholic hepatitis

Abstract: Serum IL-8 and -12 levels were markedly elevated in AH with increasing levels as the severity increases. Serum levels of IL-8 and -12 were better predictors of short-term mortality as compared to conventional prognostic scores.

Cited by 10 publications

References 29 publications

Systematic review with meta‐analysis: high mortality in patients with non‐severe alcoholic hepatitis

Systematic review with meta‐analysis: high mortality in patients with non‐severe alcoholic hepatitis

Targeting inflammation for the treatment of alcoholic liver disease

Prevention and Management of Alcoholic Liver Disease

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