Changes in circulating bile acid subtypes in response to weight-loss diets are associated with improvements in glycemic status and insulin resistance: The POUNDS Lost trial

Heianza, Yoriko; Wang, Xuan; Rood, Jennifer; Clish, Clary B.; Bray, George A.; Sacks, Frank M.; Qi, Lü

doi:10.1016/j.metabol.2022.155312

Cited by 6 publications

(1 citation statement)

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“…Accumulating evidence suggests that circulating BAs can be deeply influenced by diet. Intervention studies in adults have shown that mainly the amount of fat and fiber in the diet can modify circulating BAs, whereas observational studies have shown variable effects [29,30]. Here, we did not observe any association between dietary macronutrients or fiber intake with differentiated BAs.…”

Section: Discussioncontrasting

confidence: 81%

A dysregulated bile acids pool is associated with metabolic syndrome and gut microbial dysbiosis in early adolescence

Mancera‐Hurtado,

Lopez‐Contreras,

Flores‐Lopez

et al. 2023

Obesity

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Objective: The increased prevalence of childhood metabolic syndrome (MetS) is a public health issue. It has been shown that a dysregulated bile acid (BA) profile could be involved in the development of MetS, in which the gut microbiota could have a significant role in BA levels. This study aimed to evaluate differences in serum BA levels in children with and without MetS and whether these levels were associated with gut microbial composition.Methods: A total of 100 children aged 10 to 12 years were enrolled in this study, 42 children with MetS (cases) and 58 control participants. Serum BAs were measured by liquid chromatography-tandem mass spectrometry and gut microbiota was determined by 16S ribosomal RNA gene sequencing.Results: Children with MetS showed higher levels of total, secondary, and 12αhydroxylated BAs, as well as deoxycholic acid, and these were associated with dyslipidemia and insulin resistance markers. Interestingly, total BAs were negatively correlated with gut bacterial diversity (Shannon index: rho = À0.218, p = 0.035), whereas total, 12α-hydroxylated, and secondary BAs, as well as deoxycholic acid, showed negative correlations with genera known for their potential health effects, including Bifidobacterium, Akkermansia, and Faecalibacterium.Conclusions: This study suggests that childhood MetS is associated with a dysregulated BA pool and that these alterations could influence the abundance of potentially beneficial bacteria, thus contributing to gut microbial dysbiosis.

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Section: Discussioncontrasting

confidence: 81%