Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial

McAlindon, Timothy E.; Nuite, Melynn; Krishnan, Nitya; Ruthazer, Robin; Price, Lori Lyn; Burstein, Deborah; Griffith, John; Flechsenhar, K.

doi:10.1016/j.joca.2011.01.001

Cited by 123 publications

(126 citation statements)

References 18 publications

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“…In several clinical trials, the efficacy of oral collagen peptide supplementation could be demonstrated in osteoarthritic patients (McAlindon et al 2011;Benito-Ruiz et al 2009;Adam 1991;Krug 1979;Oberschelp 1985;Bruyère et al 2012). After treatment, significantly reduced pain and increased mobility were reported.…”

Section: Discussionmentioning

confidence: 99%

“…However, the clinical relevance of the observed effects needs to be clarified. In a placebo-controlled trial, McAlindon et al (2011) demonstrated increased content of proteoglycan as part of the ECM of cartilage tissue in patients with mild osteoarthritis after 10 g of collagen peptide intake. In addition, clinical studies with patients suffering from degenerative joint diseases showed an improvement in pain symptoms (Bello and Oesser 2006;Benito-Ruiz et al 2009;Bruyère et al 2012;Moskowitz 2000).…”

Section: Introductionmentioning

confidence: 99%

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Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Zdzieblik

Oesser

Gollhofer

et al. 2017

Appl. Physiol. Nutr. Metab.

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this article has been changed to the CC BY 4.0 license. The PDF and HTML versions of the article have been modified accordingly. Abstract:The aim of the study was to evaluate the use of specific collagen peptides in reducing pain in athletes with functional knee problems during sport. Athletic subjects (n = 139) with functional knee pain ingested 5 g of bioactive collagen peptides (BCP) or a placebo per day for 12 weeks. The primary outcome of the study was a change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale (VAS). As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. The results revealed a statistically significant improvement in activity-related pain intensity in the verum group compared with placebo. (⌬VAS BCP = 19.5 ± 2.4; ⌬VAS Placebo = 13.9 ± 2.1; p = 0.046). The results were confirmed by the physician's assessment. (⌬VAS BCP = 16.7 ± 1.8; ⌬VAS Placebo = 12.2 ± 1.8; p = 0.021). Pain under resting conditions was also improved, but no significance compared with placebo was detected (⌬VAS BCP = 10.2 ± 18.4; ⌬VAS Placebo = 7.4 ± 15.2; p = 0.209). Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after BCP intake. The study demonstrated that the supplementation of specific collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity-related joint pain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Zdzieblik

Oesser

Gollhofer

et al. 2017

Appl. Physiol. Nutr. Metab.

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“…McAlindon and colleagues (31) showed that consuming 10 g collagen hydrolysate/d resulted in an increase in collagen within the knee. In agreement with this finding, a 24-wk randomized clinical trial in athletes showed that collagen hydrolysate significantly decreased knee pain (32).…”

Section: Discussionmentioning

confidence: 99%

Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

Shaw¹,

Lee-Barthel

Ross

et al. 2017

The American Journal of Clinical Nutrition

149

205

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“…Magnetic resonance imaging (MRI) scan has been increasingly used to confirm the diagnosis, define the stages and document the evolution of OCL [21,22]. The reliability of the method to recognize cartilage changes after collagen hydrolysate (Fortigel ® ) intake was demonstrated by McAlindon [23]. A single center, prospective, randomized, placebo-controlled, double blind trial included 30 patients with mild knee osteoarthritis, whose cartilage changes were followed by two MRI techniques (delayed gadolinium enhanced magnetic resonance imaging of cartilage -dGEMRIC or T2 mapping) before and after collagen hydrolysate nutritional supplementation.…”

Section: Discussionmentioning

confidence: 99%

Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series

Gonçalves¹

2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. We report three cases of OCL in athletes, which were diagnosed and followed with magnetic resonance imaging (MRI) scan after multidisciplinary treatment including nutritional supplementation with Fortigel® a specific collagen hydrolysate that contains bioactive collagen peptides. A literature review on the role of collagen hydrolysate and its nutritional aspect in supporting the regeneration of articular cartilage is also presented. Conclusion: MRI images of patients assessed in this study depict the recovery of the articular surfaces after the treatment. Also, studies in athletes presenting joint pain but otherwise not diagnosed with osteoarthritis or other osteoarticular diseases have demonstrated the beneficial effects of CH intake. IJCRI publishes

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Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial

Abstract: These preliminary results suggest that the dGEMRIC technique may be able to detect change in proteoglycan content in knee cartilage among individuals taking collagen hydrolysate after 24 weeks.

Cited by 123 publications

References 18 publications

Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis

Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series

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