Challenges in real-life diabetes translation research: Early lessons from BRIDGES projects

Quevedo, Isabel Garcia de; Siminerio, Linda M.; L’Heveder, Ronan; Narayan, K.M. Venkat

doi:10.1016/j.diabres.2011.10.013

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…Clinical trials have shown the value of an experienced recruitment team for planning and implementing recruitment strategies and convincing eligible individuals to participate in the program [16][17][18][19]. For this trial, the recruitment team consisted of 11 multitasking members, namely; a program coordinator, four field staff which included two health educators and two medical social workers, three phlebotomists who were responsible for biochemical testing, two data entry staff and one support staff to help in coordination of the camps.…”

Section: Recruitment Teammentioning

confidence: 99%

“…Challenges of recruiting and sustaining high-risk populations for a primary prevention translational trial in India have never been reported and literature from elsewhere is scant [17][18][19]. For the interventions like the highly effective U.S. Diabetes Prevention Program (DPP) [1] to work in LMIC settings like India, the interventions will need to be generalized to all people with prediabetes, culturally modified, made low cost and sustainable and be conducted in a 'real-life' setting.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Recruitment challenges in a diabetes prevention trial in a low- and middle-income setting

Ranjani

Weber

Anjana

et al. 2015

Diabetes Research and Clinical Practice

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Section: Recruitment Teammentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Recruitment challenges in a diabetes prevention trial in a low- and middle-income setting

Ranjani

Weber

Anjana

et al. 2015

Diabetes Research and Clinical Practice

Self Cite

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“…Esta permite avaliar os padrões de atendimento, entender as barreiras da sua implementação e intervir em todos os níveis de prestação de cuidados de saúde para melhorar a qualidade dos serviços, bem como a qualidade de vida. Existem pelo menos três aspectos necessários para o sucesso na implementação clínica da pesquisa translacional: o paciente, o provedor e o sistema de saúde atuando em conjunto de modo flexível para os ajustes necessários (19).…”

Section: Pesquisa Translacionalunclassified

Pesquisa translacional em diabetes melito gestacional e hiperglicemia gestacional leve: conhecimento atual e nossa experiência

Rudge

Pículo

Marini

et al. 2013

Arq Bras Endocrinol Metab

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RESUMOO diabetes materno constitui um ambiente desfavorável para o desenvolvimento embrionário e feto--placentário. É uma repercussão de importância na obstetrícia moderna, visto que está associado a um risco aumentado de morbidade materna e neonatal e continua a ser um desafio médico significativo. O aumento mundial na incidência do diabetes, o aumento do diabetes tipo 2 em mulheres em idade reprodutiva e a geração cruzada da programação intrauterina do diabetes tipo 2 são as bases para o interesse crescente na utilização de modelos experimentais diabéticos, a fim de obter conhecimento sobre os mecanismos que induzem as alterações de desenvolvimento no diabetes gestacional. Vários estudos têm demonstrado os benefícios da prevenção do diabetes com intervenções no estilo de vida, melhora metabólica e controle de fator de risco cardiovascular para evitar substancialmente as complicações devastadores da doença. Apesar desses achados e a revolução recente no conhecimento científico e infinidade de novas terapias do diabetes, continua a haver uma grande lacuna entre o que foi aprendido por meio da pesquisa e o que é feito na prática da saúde pública, clínica e comunitária. O iminente impacto econômico negativo dessa complacência nos indivíduos, nas famílias e nas economias nacionais é alarmante. Espera-se que a pesquisa translacional no binômio diabetes-gravidez seja implementada em centros de excelência tanto de pesquisa básica como aplicada e complementada por estudos clínicos multicêntricos, conduzidos de forma pragmá-tica para aumentar o nível de evidência científica com recursos diagnósticos e propedêuticos mais confiáveis. Arq Bras Endocrinol Metab. 2013;57(7):497-508 Descritores Diabetes; gestação; modelos animais; pesquisa translacional; incontinência urinária ABSTRACT Maternal diabetes constitutes an unfavorable environment for fetal-placental and embryonic development. It is has important repercussion in modern obstetrics, since it is associated to an increased risk of neonatal and maternal morbidity, and it still is a significant medical challenge. The increased occurrence of diabetes worldwide, the increase in diabetes type 2 in women at reproductive age and the crossed generation of intrauterine programming for diabetes type 2 are the bases for the growing interest in utilization of diabetic experimental samples, with the aim to acquire knowledge about the mechanisms that induce development alterations in gestational diabetes. Several studies have shown the benefits of diabetes prevention, with interventions in lifestyle, metabolic improvement and control of cardiovascular risk factors to substantially prevent the complications of this devastating disease. Despite these findings, the recent revolution in the scientific knowledge, and the infinite number of new therapies for diabetes, there is still a large gap between what was learned through research and what is really done in public, clinical and community health. The negative economic impact of this complacency in people, families, and national econom...

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“…In the last decade, there was a notable increase of diabetes around the world [104]. The islet transplantation to patients with severe diabetes has improved their quality of life [105, 106].…”

Section: Therapeutic Strategies Based On Polymeric Microparticlesmentioning

confidence: 99%

Therapeutic Strategies Based on Polymeric Microparticles

Vilos

Velásquez

2012

Journal of Biomedicine and Biotechnology

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The development of the field of materials science, the ability to perform multidisciplinary scientific work, and the need for novel administration technologies that maximize therapeutic effects and minimize adverse reactions to readily available drugs have led to the development of delivery systems based on microencapsulation, which has taken one step closer to the target of personalized medicine. Drug delivery systems based on polymeric microparticles are generating a strong impact on preclinical and clinical drug development and have reached a broad development in different fields supporting a critical role in the near future of medical practice. This paper presents the foundations of polymeric microparticles based on their formulation, mechanisms of drug release and some of their innovative therapeutic strategies to board multiple diseases.

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Challenges in real-life diabetes translation research: Early lessons from BRIDGES projects

Cited by 7 publications

References 34 publications

Recruitment challenges in a diabetes prevention trial in a low- and middle-income setting

Recruitment challenges in a diabetes prevention trial in a low- and middle-income setting

Pesquisa translacional em diabetes melito gestacional e hiperglicemia gestacional leve: conhecimento atual e nossa experiência

Therapeutic Strategies Based on Polymeric Microparticles

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