Challenges and opportunities in early identification and intervention for children at-risk for autism spectrum disorders

Crais, Elizabeth R.; Watson, Linda R.

doi:10.3109/17549507.2013.862860

Cited by 23 publications

(13 citation statements)

References 44 publications

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“…Reducing the delay in diagnosis would enable children to begin intervention programmes earlier. If intervention occurs early, when neuronal plasticity is much greater, long-term positive results can be achieved (Crais & Watson, 2014a).…”

Section: Discussionmentioning

confidence: 99%

Early Detection, Diagnosis and Intervention Services for Young Children with Autism Spectrum Disorder in the European Union (ASDEU): Family and Professional Perspectives

Bejarano‐Martín

Canal‐Bedia

Magán‐Maganto

et al. 2019

J Autism Dev Disord

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Section: Discussionmentioning

confidence: 99%

Early Detection, Diagnosis and Intervention Services for Young Children with Autism Spectrum Disorder in the European Union (ASDEU): Family and Professional Perspectives

Bejarano‐Martín

Canal‐Bedia

Magán‐Maganto

et al. 2019

J Autism Dev Disord

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“…This testable clinical hypothesis serves to challenge our current thinking about interventions. A shift in focus may be required from intervention in school aged children to early prevention starting around 12 months of age, 139 during which time children shape and refine their neural circuitry in response to social stimuli. 140 Secondly, although the American Academy of Pediatrics' recommendation against television in children under the age of two years 141 stems from studies in a more general population of children, unfavorable neurodevelopmental and behavioral outcomes in children with ASD might be even more compounded by early media exposure.…”

Section: Discussionmentioning

confidence: 99%

A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism

Sonakya

Bigio

et al. 2014

Transl Psychiatry

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The prevalence of autism spectrum disorders (ASDs) has increased 20-fold over the past 50 years to >1% of US children. Although twin studies attest to a high degree of heritability, the genetic risk factors are still poorly understood. We analyzed data from two independent populations using u-statistics for genetically structured wide-locus data and added data from unrelated controls to explore epistasis. To account for systematic, but disease-unrelated differences in (non-randomized) genome-wide association studies (GWAS), a correlation between P-values and minor allele frequency with low granularity data and for conducting multiple tests in overlapping genetic regions, we present a novel study-specific criterion for ‘genome-wide significance'. From recent results in a comorbid disease, childhood absence epilepsy, we had hypothesized that axonal guidance and calcium signaling are involved in autism as well. Enrichment of the results in both studies with related genes confirms this hypothesis. Additional ASD-specific variations identified in this study suggest protracted growth factor signaling as causing more severe forms of ASD. Another cluster of related genes suggests chloride and potassium ion channels as additional ASD-specific drug targets. The involvement of growth factors suggests the time of accelerated neuronal growth and pruning at 9–24 months of age as the period during which treatment with ion channel modulators would be most effective in preventing progression to more severe forms of autism. By extension, the same computational biostatistics approach could yield profound insights into the etiology of many common diseases from the genetic data collected over the last decade.

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“…Others argue that there are many potential benefits from earlier intervention when significant risk markers are present (Crais & Watson, 2014). The blurring of diagnostic boundaries, especially in children under 5 years, has led some to call for a less rigid and more holistic approach to screening, diagnosis, and early intervention (Gillberg, 2010).…”

Section: Sensitivity and Specificity: Difficulties Of Screening Complmentioning

confidence: 99%

Effectiveness of the ADEC as a Level 2 screening test for young children with suspected autism spectrum disorders in a clinical setting

Dix

Fallows

Murphy

2015

Journal of Intellectual and Developmental Disability

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Challenges and opportunities in early identification and intervention for children at-risk for autism spectrum disorders

Cited by 23 publications

References 44 publications

Early Detection, Diagnosis and Intervention Services for Young Children with Autism Spectrum Disorder in the European Union (ASDEU): Family and Professional Perspectives

Early Detection, Diagnosis and Intervention Services for Young Children with Autism Spectrum Disorder in the European Union (ASDEU): Family and Professional Perspectives

A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism

Effectiveness of the ADEC as a Level 2 screening test for young children with suspected autism spectrum disorders in a clinical setting

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