CHA2DS2‐VASc scores predict major adverse cardiovascular events in patients with chronic obstructive pulmonary disease

Ooi, Hean; Chen, Li-Hsiou; Ni, Yung-Lun; Shen, Huan-Ting; Lee, Yen‐Hsien; Chu, Yi-Chun; Fang, Ke-Chih; Chen, I-Hung; Hsu, Shu-Lan; Chen, Hsing-Chun; Huang, Chienhsiu; Fan, Kuo-Sheng; Lai, Chun‐Liang; Hang, Liang‐Wen

doi:10.1111/crj.12624

Cited by 11 publications

(12 citation statements)

References 31 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; Ooi et al. ). A greater understanding of this pathway may contribute to the development of new therapeutic strategies.…”

Section: Discussionmentioning

confidence: 97%

“…A potential influence of activation of pulmonary spinal afferents is their contribution to the increased risk of cardiovascular events and reduced prognosis in patients with existing disease. For instance, those suffering from chronic obstructive pulmonary disease (COPD) are more likely to have major adverse cardiovascular events from cardiovascular comorbidities than those without COPD (Calverley and Scott 2006;Alvarez et al 2008;Zoccali et al 2013;Ooi et al 2018). A greater understanding of this pathway may contribute to the development of new therapeutic strategies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats

et al. 2018

View full text Add to dashboard Cite

The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological effects mediated by spinal sympathetic afferent fibers. We hypothesized that activation of sympathetic spinal afferent nerve fibers of the lung would result in an excitatory pressor reflex, similar to that previously characterized in the heart. In this study, we evaluated changes in renal sympathetic nerve activity (RSNA) and hemodynamics in response to activation of TRPV1‐sensitive pulmonary spinal sensory fibers by agonist application to the visceral pleura of the lung and by administration into the primary bronchus in anesthetized, bilaterally vagotomized, adult Sprague‐Dawley rats. Application of bradykinin (BK) to the visceral pleura of the lung produced an increase in mean arterial pressure (MAP), heart rate (HR), and RSNA. This response was significantly greater when BK was applied to the ventral surface of the left lung compared to the dorsal surface. Conversely, topical application of capsaicin (Cap) onto the visceral pleura of the lung, produced a biphasic reflex change in MAP, coupled with increases in HR and RSNA which was very similar to the hemodynamic response to epicardial application of Cap. This reflex was also evoked in animals with intact pulmonary vagal innervation and when BK was applied to the distal airways of the lung via the left primary bronchus. In order to further confirm the origin of this reflex, epidural application of a selective afferent neurotoxin (resiniferatoxin, RTX) was used to chronically ablate thoracic TRPV1‐expressing afferent soma at the level of T1–T4 dorsal root ganglia pleura. This treatment abolished all sympatho‐excitatory responses to both cardiac and pulmonary application of BK and Cap in vagotomized rats 9–10 weeks post‐RTX. These data suggest the presence of an excitatory pulmonary chemosensitive sympathetic afferent reflex. This finding may have important clinical implications in pulmonary conditions inducing sensory nerve activation such as pulmonary inflammation and inhalation of chemical stimuli.

show abstract

“…; Ooi et al. ). A greater understanding of this pathway may contribute to the development of new therapeutic strategies.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In addition, a potential influence of activation of pulmonary spinal afferents expressing TRPV1 is their contribution to the increased risk of cardiovascular events and a poor prognosis in patients with existing disease. For instance, those suffering from COPD are more likely to have major adverse cardiovascular events from cardiovascular comorbidities than those without COPD (Villar Alvarez et al, 2008; Ooi et al, 2018).…”

Section: Trpv1 and Diseasementioning

confidence: 99%

The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Liao

Chen

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.

show abstract

“…CHA 2 DS 2 -VASc scores are known to predict ischemic stroke risk in patients with atrial fibrillation. Moreover, a previous study validated the utility of CHA 2 DS 2 -VASc scores for predicting major adverse cardiovascular event risk in patients with COPD 24 . In the present study, patients with lower CHA 2 DS 2 -VASc scores or ORBIT scores had significant high VA risk than non-COPD patients with same score.…”

Section: Discussionmentioning

confidence: 89%

Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study

Chen

Lin

Hao

et al. 2021

npj Prim. Care Respir. Med.

View full text Add to dashboard Cite

The ventricular arrhythmia (VA)–chronic obstructive pulmonary disease (COPD) association and related risk factors remain unclear. Using 2001–2012 data from National Health Insurance Research Database, we retrospectively reviewed 71,838 patients diagnosed as having COPD and 71,838 age- and sex-matched controls. After adjustments for comorbidities, medication, urbanization level, and monthly income, patients with COPD had higher incidence rates of VA than did the controls (adjusted hazard ratio [aHR] [95% confidence interval (CI)]: 1.45 [1.25–1.68]). More hospitalization or emergency visits because of acute COPD exacerbation (aHRs [95% CIs] for first, second, and third visits: 1.28 [1.08–1.50], 1.75 [1.32–2.32], and 1.88 [1.46–2.41], respectively) and asthma–COPD overlap (aHR [95% CI]: 1.49 [1.25–1.79]) were associated with high VA risk in patients with COPD. In the multivariate analysis, heart failure (aHR [95% CI]: 2.37 [1.79–3.14]), diabetes (aHR [95% CI]:1.64 [1.29–2.08]), age ≥75 (aHR [95% CI]: 2.48 [1.68–3.67]), male (aHR [95% CI]: 1.69[1.34–2.12]), and class III antiarrhythmic drug use (aHR [95% CI]: 2.49 [1.88–3.28]) are the most significant risk factors of new onset of VA in patients with COPD.

show abstract

CHA2DS2‐VASc scores predict major adverse cardiovascular events in patients with chronic obstructive pulmonary disease

Abstract: Early lifestyle modifications and antithrombotic therapy may be essential for COPD patients at a high risk of MACEs, that is, those with CHA2DS2-VASc scores ≥ 6.

Cited by 11 publications

References 31 publications

Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats

Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats

The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Association between chronic obstructive pulmonary disease and ventricular arrhythmia: a nationwide population-based cohort study

Contact Info

Product

Resources

About