The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Du, Qian; Liao, Qiushi; Chen, Changmei; Yang, Xiaoxu; Xie, Rui; Xu, Jingyu

doi:10.3389/fphys.2019.01064

Cited by 93 publications

(91 citation statements)

References 153 publications

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“…Transient receptor potential vanilloid-receptor-related (TRPV) channels 1-4 have been identified in murine and rat arteries and nerves (Earley and Brayden, 2015;Du et al, 2019). TRPV3 and TRPV4 are expressed both in endothelial and VSM cells, TRPV1 in endothelial cells and sensory nerve fibers, while TRPV2 were found only in VSM cells (Earley and Brayden, 2015).…”

Section: Menthol Actions On Trpv Channelsmentioning

confidence: 99%

Current Knowledge on the Vascular Effects of Menthol

Silva

2020

Front. Physiol.

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Menthol is a monoterpene alcohol, widely used in several food and healthcare products for its particular odor and flavor. For some decades, menthol has been known to act on the vasculature directly in the endothelium and vascular smooth muscle, with recent studies showing that it also evokes an indirect vascular response via sensory fibers. The mechanisms underlying menthol's vascular action are complex due to the diversity of cellular targets, to the interplay between signaling pathways and to the variability in terms of response. Menthol can evoke either a perfusion increase or decrease in vivo in different vascular territories, an observation that warrants a critical discussion. Menthol vascular actions in vivo seem to depend on whether the vascular territory under analysis has been directly provoked with menthol or is located deep/distant to the application site. Menthol increases perfusion of directly provoked skin regions due to a complex interplay of increased nitric oxide (NO), endothelium-derived hyperpolarization factors (EDHFs) and sensory nerve responses. In non-provoked vascular beds menthol decreases perfusion which might be attributed to heat-conservation sympatheticallymediated vasoconstriction, although an increase in tissue evaporative heat loss due the formulation ethanol may also play a role. There is increasing evidence that several of menthol's cellular targets are involved in cardiovascular diseases, such as hypertension. Thus menthol and pharmacologically-similar drugs can play important preventive and therapeutic roles, which merits further investigation.

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Section: Menthol Actions On Trpv Channelsmentioning

confidence: 99%

Current Knowledge on the Vascular Effects of Menthol

Silva

2020

Front. Physiol.

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“…This model also induces an increase in the proportion of capsaicin sensitive pancreas-specific DRG neurons, as well as the over expression of NGF, artemin, and GDNF (90,128). The increased expression of NGF and the GDNF artemin may thus activate TRPV1 on intrapancreatic nerves resulting in the release of substance P (SP) and the maintenance of the disease state (129).…”

Section: Neural Trp Channels In the Context Of Inflammation Trpv1mentioning

confidence: 99%

Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation

et al. 2020

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Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms. In the context of ion channels, they are unique for their broad diversity of activation mechanisms and their cation selectivity. TRP channels are involved in a diverse range of physiological processes including chemical sensing, nociception, and mediating cytokine release. They also play an important role in the regulation of inflammation through sensory function and the release of neuropeptides. In this review, we discuss the functional contribution of a subset of TRP channels (TRPV1, TRPV4, TRPM3, TRPM8, and TRPA1) that are involved in the body's immune responses, particularly in relation to inflammation. We focus on these five TRP channels because, in addition to being expressed in many somatic cell types, these channels are also expressed on peripheral ganglia and nerves that innervate visceral organs and tissues throughout the body. Activation of these neural TRP channels enables crosstalk between neurons, immune cells, and epithelial cells to regulate a wide range of inflammatory actions. TRP channels act either through direct effects on cation levels or through indirect modulation of intracellular pathways to trigger pro-or antiinflammatory mechanisms, depending on the inflammatory disease context. The expression of TRP channels on both neural and immune cells has made them an attractive drug target in diseases involving inflammation. Future work in this domain will likely yield important new pathways and therapies for the treatment of a broad range of disorders including colitis, dermatitis, sepsis, asthma, and pain.

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“…Capsaicin is a significant agonist for TRPV1 with an exquisite selectivity and allyl isothiocyanate (AITC), the pungent ingredient in garlic, is the prototypical agonist for TRPA1 (8,9). TRPV4 colocalizes with TRPV1, TRPA1, and protease-activated receptors 2 (PAR-2) in the GI tract, in response to strong acidosis, hypotonicity, warmth, and mechanical stimuli (10,11). TRPM2 is sensitive to heat stimulus while TRPM8 is essential to cold-induced pain (12).…”

Section: Trp Channels In the Gi Tract And Related Neuropeptidesmentioning

confidence: 99%

“…Upon stimulation, TRP channels in afferents can lead to autonomic reflex responses by transmitting signals to the central nervous system. Meanwhile, TRP channels can transduce sensory signal of G-protein coupled receptors (GPCRs) based on the phosphorylation sites in N-terminus for serine and threonine protein kinases, such as protein kinase A (PKA) and protein kinase C (PKC) (11,13).…”

Section: Trp Channels In the Gi Tract And Related Neuropeptidesmentioning

confidence: 99%

Transient Receptor Potential Channels and Inflammatory Bowel Disease

Chen

Zhu

et al. 2020

Front. Immunol.

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The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors. The activation of TRP channels triggers neurogenic inflammation with related neuropeptides and initiates immune reactions by extra-neuronally regulating immune cells, contributing to the GI homeostasis. However, under pathological conditions, such as inflammatory bowel disease (IBD), TRP channels are involved in intestinal inflammation. An increasing number of human and animal studies have indicated that TRP channels are correlated to the visceral hypersensitivity (VHS) and immune pathogenesis in IBD, leading to an exacerbation or amelioration of the VHS or intestinal inflammation. Thus, TRP channels are a promising target for novel therapeutic methods for IBD. In this review, we comprehensively summarize the functions of TRP channels, especially their potential roles in immunity and IBD. Additionally, we discuss the contradictory findings of prior studies and offer new insights with regard to future research.

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The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Cited by 93 publications

References 153 publications

Current Knowledge on the Vascular Effects of Menthol

Current Knowledge on the Vascular Effects of Menthol

Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation

Transient Receptor Potential Channels and Inflammatory Bowel Disease

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