Cerium Oxide Nanoparticles: the Regenerative Redox Machine in Bioenergetic Imbalance

Pezzini, Ilaria; Marino, Attilio; Turco, Serena Del; Nesti, Claudia; Doccini, Stefano; Cappello, Valentina; Gemmi, Mauro; Parlanti, Paola; Santorelli, Filippo M.; Mattoli, Virgilio; Ciofani, Gianni

doi:10.2217/nnm-2016-0342

Cited by 54 publications

(55 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, cerium oxide nanoparticles have been shown to protect primary cultured skin fibroblasts from hydrogen peroxide induced damage [7]. This is in line with earlier published data [6], showing that nanoceria protect human dermal fibroblast from another oxidative insult, namely paraquat.…”

Section: Cnp Treatment Decreases the Amount Of Total Atp In Melanoma supporting

confidence: 80%

“…Redox-based therapies show very promising results [1,2], especially the SOD-mimetic as well as the catalase mimetic activity of nanoceria [3,4]. Interestingly, CNP at concentrations of 150-300 μM show on one hand a selective antioxidative property in normal (healthy) cells protecting these cells against oxidative impacts such as paraquat or hydrogen peroxide, and on the other hand CNP show a prooxidative cytotoxic activity in tumor cells [5][6][7]. These unique features point to a promising therapeutic potential of CNP for further in vivo studies in the near future [1].…”

Section: Introductionmentioning

confidence: 99%

“…Fusion and fission are part of the mitochondrial quality control [24,25], and it has been published that morphological and ultrastructural changes, that lead to a disturbed quality control of mitochondria, are often induced by ROS [26,27]. CNP have been reported to diminish oxidant-induced ROS production in human dermal fibroblasts [6,7], concomitant with a rescue of mitochondrial membrane potential (MMP) and mitochondrial morphology, i.e. fusion and fission [7].…”

Section: Introductionmentioning

confidence: 99%

“…CNP have been reported to diminish oxidant-induced ROS production in human dermal fibroblasts [6,7], concomitant with a rescue of mitochondrial membrane potential (MMP) and mitochondrial morphology, i.e. fusion and fission [7]. In tumor cells, however, already elevated ROS level lead to a change in the cellular metabolism and signaling cascade [28,29], a phenomenon recently described as redox signaling [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction

et al. 2020

View full text Add to dashboard Cite

Cerium (Ce) oxide nanoparticles (CNP; nanoceria) are reported to have cytotoxic effects on certain cancerous cell lines, while at the same concentration they show no cytotoxicity on normal (healthy) cells. Redox-active CNP exhibit both selective prooxidative as well as antioxidative properties. The former is proposed to be responsible for impairment of tumor growth and invasion and the latter for rescuing normal cells from reactive oxygen species (ROS)-induced damage. Here we address possible underlying mechanisms of prooxidative effects of CNP in a metastatic human melanoma cell line. Malignant melanoma is the most aggressive form of skin cancer, and once it becomes metastatic the prognosis is very poor. We have shown earlier that CNP selectively kill A375 melanoma cells by increasing intracellular ROS levels, whose basic amount is significantly higher than in the normal (healthy) counterpart, the melanocytes. Here we show that CNP initiate a mitochondrial increase of ROS levels accompanied by an increase in mitochondrial thiol oxidation. Furthermore, we observed CNP-induced changes in mitochondrial bioenergetics, dynamics, and cristae morphology demonstrating mitochondrial dysfunction which finally led to tumor cell death. CNPinduced cell death is abolished by administration of PEG-conjugated catalase. Overall, we propose that cerium oxide nanoparticles mediate cell death via hydrogen peroxide production linked to mitochondrial dysfunction.

show abstract

Section: Cnp Treatment Decreases the Amount Of Total Atp In Melanoma supporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In the last decade, many in vitro and in vivo studies demonstrated the strong biological antioxidant properties of nanoceria, reducing both basal and stress‐induced ROS, and acting as prosurvival agents . Based on these excellent properties, cerium oxide nanoparticles have become a promising pharmacological tool for the treatment of many diseases associated with oxidative stress.…”

Section: Redox‐active Nanoparticlesmentioning

confidence: 99%

Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future

Genchi

Marino

Grillone

et al. 2017

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

The remote control of cellular functions through smart nanomaterials represents a biomanipulation approach with unprecedented potential applications in many fields of medicine, ranging from cancer therapy to tissue engineering. By actively responding to external stimuli, smart nanomaterials act as real nanotransducers able to mediate and/or convert different forms of energy into both physical and chemical cues, fostering specific cell behaviors. This report describes those classes of nanomaterials that have mostly paved the way to a "wireless" control of biological phenomena, focusing the discussion on some examples close to the clinical practice. In particular, magnetic fields, light irradiation, ultrasound, and pH will be presented as means to manipulate the cellular fate, due to the peculiar physical/chemical properties of some smart nanoparticles, thus providing realistic examples of "nanorobots" approaching the visionary ideas of Richard Feynman.

show abstract

Evaluation of Reactive Oxygen Species Scavenging of Polydopamine with Different Nanostructures

Zheng,

Chen,

Zhang

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Reactive oxygen species (ROS) play an important role in cellular metabolism and many oxidative stress‐related diseases, while excessive accumulation of ROS will lead to genetic changes in cells and promote the occurrence of inflammatory diseases or cell death. Nature‐inspired polydopamine (PDA) with tailored nanostructures emerges as an ROS scavenger and is considered as an effective approach to inflammation‐related diseases. However, the effects of nanoparticle structure on PDA scavenging efficacy and efficiency remain uncovered. In this work, three typical PDA nanoparticles including solid PDA, mesoporous PDA, and hollow PDA are synthesized, and of which physiochemical properties are characterized. Furthermore, their ROS scavenging performance is investigated by in vitro evaluation of radical removal. Among the three nanoparticles, mesoporous PDA is demonstrated to have the highest scavenging capability, mainly due to its specific surface area. Finally, the study on three in vivo inflammation models is constructed. The results confirm that mesoporous PDA is the most potent scavenger of ROS and more effective in reducing reperfusion injury, improving renal function, and preventing periodontitis progression, respectively. Together with the good biosafety and biocompatibility profiles, PDA nanoparticles, mesoporous PDA in particular, can be a promising avenue of ROS scavenging in fight against the inflammatory diseases.

show abstract

Cerium Oxide Nanoparticles: the Regenerative Redox Machine in Bioenergetic Imbalance

Abstract: Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.

Cited by 54 publications

References 59 publications

CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction

CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction

Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future

Evaluation of Reactive Oxygen Species Scavenging of Polydopamine with Different Nanostructures

Contact Info

Product

Resources

About