Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future

Genchi, Giada Graziana; Marino, Attilio; Grillone, Agostina; Pezzini, Ilaria; Ciofani, Gianni

doi:10.1002/adhm.201700002

Cited by 42 publications

(35 citation statements)

References 170 publications

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“…A consolidated method for the fine modulation of the activity of specific cell types is represented by optogenetics, which consists in the genetic sensitization of targeted cells to light through a promoter-driven expression of light-sensitive proteins. Alternatively, a new generation of smart nanomaterial-based approaches for the remote control of cell behavior has recently been proposed (Genchi et al, 2017a ). Smart nanomaterials can be externally/wirelessly activated by different energy sources [e.g., near-infrared (NIR) radiations, radiofrequency stimulations, magnetic fields, ultrasounds, etc.]…”

Section: Remote Cell Stimulation Through Smart Nanomaterialsmentioning

confidence: 99%

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Genchi

Marino

Tapeinos

et al. 2017

Front. Bioeng. Biotechnol.

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With the increasing advances in the fabrication and in monitoring approaches of nanotechnology devices, novel materials are being synthesized and tested for the interaction with biological environments. Among them, smart materials in particular provide versatile and dynamically tunable platforms for the investigation and manipulation of several biological activities with very low invasiveness in hardly accessible anatomical districts. In the following, we will briefly recall recent examples of nanotechnology-based materials that can be remotely activated and controlled through different sources of energy, such as electromagnetic fields or ultrasounds, for their relevance to both basic science investigations and translational nanomedicine. Moreover, we will introduce some examples of hybrid materials showing mutually beneficial components for the development of multifunctional devices, able to simultaneously perform duties like imaging, tissue targeting, drug delivery, and redox state control. Finally, we will highlight challenging perspectives for the development of theranostic agents (merging diagnostic and therapeutic functionalities), underlining open questions for these smart nanotechnology-based devices to be made readily available to the patients in need.

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Section: Remote Cell Stimulation Through Smart Nanomaterialsmentioning

confidence: 99%

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Genchi

Marino

Tapeinos

et al. 2017

Front. Bioeng. Biotechnol.

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“…The smartness of material development always comes from the inspiration and intelligence of nature. Smart materials can be defined as materials that incorporate the functions of sensing, actuation, and control [1,2]. Smart materials are attracting increasing interest especially in the era of the fourth industrial revolution (Industry 4.0) and circular economy.…”

Section: Introductionmentioning

confidence: 99%

Smart polymer nanocomposites: A review

Chow¹,

Ishak²

2020

Express Polym. Lett.

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The development of smart polymer nanocomposites (SPN) has been an area of high scientific and industrial interest in recent years, due to fantastic improvements achieved in these materials. SPN found potential applications in shape memory, self-healing, self-sensing, self-heating, self-cleaning, and energy harvesting. This mini-review highlights the current research and development on SPN, specifically on shape memory polymer (SMP) and self-healing polymer (SHP) nanocomposites. The processing techniques for SPN nanocomposites, for example, polymerization, melt-compounding, solution mixing, electrospinning, and thermoset-curing are discussed. Some of the potential strategies to modify the properties of SMP and SHP nanocomposites are highlighted. The future perspective and recommended works for the SPN nanocomposites are shared in this mini-review.

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“…NBMs are a special category of biomaterials, which possess a constituent or have a surface dimension in the nano range (i.e., 1–100 nm) [ 1 ]. These new materials can offer unprecedented technological benefits as their interactions with the biological systems can improve biocompatibility as well as clinical efficacy, while reducing adverse effects [ 2 , 3 , 4 , 5 ]. However, because of their more complex nature and nano-bio/eco interactions (i.e., interactions of the nano-sized component with biological molecules and structures, and with the surrounding environmental media in case of release in the environment), there are both scientific and societal concerns about their possible health and/or environmental risks.…”

Section: Introductionmentioning

confidence: 99%

Risk Management Framework for Nano-Biomaterials Used in Medical Devices and Advanced Therapy Medicinal Products

et al. 2020

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The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns that applications of NBMs for medical diagnostics, therapeutics and regenerative medicine could also pose health and/or environmental risks since the current understanding of their safety is incomplete. A scientific strategy is therefore needed to assess all risks emerging along the life cycles of these products. To address this need, an overarching risk management framework (RMF) for NBMs used in MD and ATMP is presented in this paper, as a result of a collaborative effort of a team of experts within the EU Project BIORIMA and with relevant inputs from external stakeholders. The framework, in line with current regulatory requirements, is designed according to state-of-the-art approaches to risk assessment and management of both nanomaterials and biomaterials. The collection/generation of data for NBMs safety assessment is based on innovative integrated approaches to testing and assessment (IATA). The framework can support stakeholders (e.g., manufacturers, regulators, consultants) in systematically assessing not only patient safety but also occupational (including healthcare workers) and environmental risks along the life cycle of MD and ATMP. The outputs of the framework enable the user to identify suitable safe(r)-by-design alternatives and/or risk management measures and to compare the risks of NBMs to their (clinical) benefits, based on efficacy, quality and cost criteria, in order to inform robust risk management decision-making.

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Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future

Cited by 42 publications

References 170 publications

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Smart polymer nanocomposites: A review

Risk Management Framework for Nano-Biomaterials Used in Medical Devices and Advanced Therapy Medicinal Products

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