Cerium oxide nanoparticles: properties, biosynthesis and biomedical application

Singh, Kshitij RB; Nayak, Vanya; Sarkar, Tanushri; Singh, Ravindra Pratap

doi:10.1039/d0ra04736h

Cited by 246 publications

(119 citation statements)

References 201 publications

(230 reference statements)

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“…NMs can act as bioreceptors as well as transducers. For example, cerium oxide-based NMs exhibit biomimetic catalytic activity favorable for bioreceptors [ 69 ]. Due to their effective transduction capabilities, different inorganic materials, such as graphene and CNTs-based NMs, noble metal NPs, and QDs, have successfully been used as transducers.…”

Section: Biosensormentioning

confidence: 99%

A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

Naresh

Lee

2021

Sensors

960

427

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A biosensor is an integrated receptor-transducer device, which can convert a biological response into an electrical signal. The design and development of biosensors have taken a center stage for researchers or scientists in the recent decade owing to the wide range of biosensor applications, such as health care and disease diagnosis, environmental monitoring, water and food quality monitoring, and drug delivery. The main challenges involved in the biosensor progress are (i) the efficient capturing of biorecognition signals and the transformation of these signals into electrochemical, electrical, optical, gravimetric, or acoustic signals (transduction process), (ii) enhancing transducer performance i.e., increasing sensitivity, shorter response time, reproducibility, and low detection limits even to detect individual molecules, and (iii) miniaturization of the biosensing devices using micro-and nano-fabrication technologies. Those challenges can be met through the integration of sensing technology with nanomaterials, which range from zero- to three-dimensional, possessing a high surface-to-volume ratio, good conductivities, shock-bearing abilities, and color tunability. Nanomaterials (NMs) employed in the fabrication and nanobiosensors include nanoparticles (NPs) (high stability and high carrier capacity), nanowires (NWs) and nanorods (NRs) (capable of high detection sensitivity), carbon nanotubes (CNTs) (large surface area, high electrical and thermal conductivity), and quantum dots (QDs) (color tunability). Furthermore, these nanomaterials can themselves act as transduction elements. This review summarizes the evolution of biosensors, the types of biosensors based on their receptors, transducers, and modern approaches employed in biosensors using nanomaterials such as NPs (e.g., noble metal NPs and metal oxide NPs), NWs, NRs, CNTs, QDs, and dendrimers and their recent advancement in biosensing technology with the expansion of nanotechnology.

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Section: Biosensormentioning

confidence: 99%

A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

Naresh

Lee

2021

Sensors

960

427

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“…It is a convenient material for treating ROS mediated disorders such as neurogenerative disorder, retinal disorder, cancer, and inflammation, and others [ 39 , 40 ]. It is observed that CeO 2 acts as a catalyst that mimics the features of antioxidant enzymes such as superoxide dismutase (SOD), catalase, and oxidase, in terms of scavenging ROS and free radicals [ 31 , 41 , 42 ]. Nanoceria has been reported to cause selective toxicity towards human lung cancer cells and prostate cancer cells but has shown no toxicity to normal cells (L929).…”

Section: Features Of Metal Oxides Related To Biomedical Applicatiomentioning

confidence: 99%

Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

et al. 2021

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In the past few decades, curcumin, a natural polyphenolic phytochemical, has been studied for treating a wide variety of diseases. It has shown promising results as a potential curative agent for a variety of diseases. However, its inherent limitations, such as poor aqueous solubility, poor absorbability, fast metabolic rate, and quick elimination from the body, have limited its application beyond preclinical studies. A huge number of studies have been made to address the issues of curcumin and to maximally utilize its potentials. Many review articles have tried to assess and summarize different nanocarriers, especially organic nanocarriers, for nanoformulations with curcumin. Nevertheless, few exclusive reviews on the progress in nanoformulation of curcumin with inorganic nanomaterials have been made. In this review, we present an exclusive summary of the progress in nanoformulation of curcumin with metal oxide nanoparticles. The beneficial feature of the metal oxide nanoparticles used in the curcumin nanoformulation, the different approaches followed in formulating curcumin with the metal oxides, and the corresponding results, protective effect of curcumin from different metal oxide caused toxicities, and concluding remarks are presented in the review.

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“…The biological synthesis of CeO2-NP was performed according to the common methods reported in the literature [6][7][8] yet with some modifications and optimization in the synthesis effectiveness variable, including the cerium salt concentration, extract volume, temperature, and time. Optimizations in the process of synthesizing CeO2-NP was based on achieving the highest absorption spectra intensity within 300-330 nm (due to charge transfer from O2P to Ce4f orbitals) [31], which was measured and recorded by a UV-Vis spectrophotometer.…”

Section: Biosynthesis Of Ceo2-npmentioning

confidence: 99%

“…In addition, the CeO2 prepared with these methods is toxic and unstable, reducing its efficiency [4,5]. Accordingly, in recent decades, a safe, non-toxic, eco-friendly, and low cost approach, known as biological (green) synthesis, is used by researchers for production of metal oxide nanoparticales, including CeO2 [6][7][8]. This approach employs various biological resources such as plants, microbes, or any other biological derivative (primary and secondary metabolites) believed to lead to reduction and stabilization.…”

Section: Introductionmentioning

confidence: 99%

Low-cost, simple and eco-friendly biosynthesis of CeO2-NPs using extract of Pelargonium hortorum for the photocatalytic and antioxidant applications

Mahabadi

Mirzakhani

Azizi

et al. 2021

Preprint

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In this paper, firstly the phytochemical composition in the aqueous extract of Pelargonium, growing wildly in the center of Iran, was studied. Folin–Ciocalteu and Aluminum chloride methods and the GC/MS technique were used to determine the total phenolic, flavonoid contents, and volatile constituents in the extract, respectively. The amounts of the total phenolic and flavonoid contents in the extract were found to be 136.5 mg GA/g and 63.9 mg RU/g, respectively. Twenty-one compounds, representing 15 (about 80.0%) of the total volatile constituents were identified. The main components of the volatile constituent were α-pinene (25.28%) and fenchyl acetate (20.63%). Secondly, a fast, simple, and eco-friendly biosynthesis of cerium oxide nanoparticles (CeO2-NPs) were investigated using the extract of Pelargonium as a natural reducing and stabilizing agent. Several advance techniques such as Ultraviolet-Visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Scanning electron microcopy (FESEM), Dynamic light scattering (DLS), and Brunaure Emmett-Teller (BET) were used for the analysis and characterization of the synthesized nanoparticles. The results of the characterization analysis showed that the prepared nanoparticles were spherical in shape, with an average size of 28 nm and zeta potential of -25.8 mV, and had 33.84 m2/g BET surface area, 9.31 nm mane diameter pore, and a total pore volume of 0.078 cm3/g. Finally, the practical applications including the antioxidant and photocatalyst activity of the biosynthesized CeO2-NPs were evaluated. An analysis of antioxidant and catalytic activities showed that the biosynthesized CeO2-NPs have a good ability of scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical with the IC50 value of 42.7 µg/mL and also good reduction ability of hexavalent chromium {Cr(VI)} ions with a reduction efficiency of 94% in an aqueous solution containing 10 mg/L of Cr(VI) of ion with natural pH of 5.5 and CeO2-NPs dose of 200 mg/L during 60 min.

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Cerium oxide nanoparticles: properties, biosynthesis and biomedical application

Abstract: Cerium oxide nanoparticles have revolutionized the biomedical field and is still in very fast pace of development. Hence, this work elaborates the physicochemical properties, biosynthesis, and biomedical applications of cerium oxide nanoparticles.

Cited by 246 publications

References 201 publications

A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

Low-cost, simple and eco-friendly biosynthesis of CeO2-NPs using extract of Pelargonium hortorum for the photocatalytic and antioxidant applications

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