Cerium nitrate treatment prevents progressive tissue necrosis in the zone of stasis following burn

Eski, Muhitdin; Özer, Fırat; Fırat, Cemal; Alhan, Doğan; Arslan, Nuri; Senturk, Tolga; Işık, Selçuk

doi:10.1016/j.burns.2011.08.008

Cited by 50 publications

(30 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3(a)) and are typically not differentiated clinically until several days after the burn injury [2][3][4]. Because earlier intervention has been shown to shorten hospital stays [7][8][9] and improve the healing response for patients [6], we examined these burn wounds with LSI and SFDI shortly after the initial burn and for three days post-burn to determine when these imaging techniques could reliably categorize burn severity.…”

Section: Discussionmentioning

confidence: 99%

“…This is largely due to the dynamic nature of burn wounds during the first 48 hours. This is also the reason that clinical assessments are typically made several days after the initial burn [2] even though earlier intervention has been shown to improve healing [6], reduce complication rates (infection, scarring) and shorten hospital stays for patients [7][8][9]. This highlights the rationale for developing new objective techniques that will enable more timely decision making related to burn wound severity and management.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI)

Ponticorvo¹,

Burmeister²,

Yang³

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

Accurate and timely assessment of burn wound severity is a critical component of wound management and has implications related to course of treatment. While most superficial burns and full thickness burns are easily diagnosed through visual inspection, burns that fall between these extremes are challenging to classify based on clinical appearance. Because of this, appropriate burn management may be delayed, increasing the risk of scarring and infection. Here we present an investigation that employs spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) as non-invasive technologies to characterize in-vivo burn severity. We used SFDI and LSI to investigate controlled burn wounds of graded severity in a Yorkshire pig model. Burn wounds were imaged starting at one hour after the initial injury and daily at approximately 24, 48 and 72 hours post burn. Biopsies were taken on each day in order to correlate the imaging data to the extent of burn damage as indicated via histological analysis. Changes in reduced scattering coefficient and blood flow could be used to categorize burn severity as soon as one hour after the burn injury. The results of this study suggest that SFDI and LSI information have the potential to provide useful metrics for quantifying the extent and severity of burn injuries. Durkin, "Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity," J. ©2014 Optical Society of America

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI)

Ponticorvo¹,

Burmeister²,

Yang³

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…In fact, rare earth elements have many applications in medicine such as cerium compounds being applied in burns treatment [20, 21]. Lanthanum, a light rare earth element, has potential applications in medicine [22] and lanthanum carbonate is used in the treatment of hyperphosphatemia [23, 24].…”

Section: Introductionmentioning

confidence: 99%

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Chen

Xiao

Xing

et al. 2017

Cell Physiol Biochem

4,205

View full text Add to dashboard Cite

Background/Aims: To investigate the regulation of LaCl₃ on lipopolysaccharides (LPS)-induced pro-inflammatory cytokines and adhesion molecules in human umbilical vein endothelial cells (HUVECs). Methods: Primary cultured HUVECs were pretreated with 2.5 µM LaCl₃ for 30 min followed by 1 µg/ml LPS for 2 h. Pro-inflammatory cytokine and adhesion molecule expressions were determined by real-time RT-PCR and ELISA. NF-κB/p65 nuclear translocation was examined by immunofluorescence and immuno-blot, and its DNA-binding activity was measured by chemiluminescence. Recruitment of NF-κB/p65, Jmjd3, and H3K27me3 to gene promoter regions was determined by ChIP-qPCR. Results: LaCl₃ exhibited no cytotoxic effects to primary HUVECs at concentrations ≤ 50 µM. LPS-mediated TNF-α, IL-1β, IL-6, MMP-9, and ICAM-1 production, nuclear translocation, and DNA-binding activity of NF-κB/p65, as well as Jmjd3 expression, were all reduced significantly by LaCl₃. Furthermore, LaCl₃ treatment significantly impaired LPS-induced enrichment of NF-κB/p65 to the promoter regions of TNF-α, MMP-9, IL-1β, ICAM-1, and IL-6; and of Jmjd3 to the promoter regions of TNF-α, MMP-9, IL-1β, and IL-6. H3K27me3 abundance in the promoter regions of TNF-α and ICAM-1 increased significantly in following LaCl₃ treatment. Conclusion: LaCl₃ inhibits pro-inflammatory cytokine and adhesion molecule expressions induced by LPS in HUVECs. NF-κB and histone demethylase Jmjd3 are involved in this effect.

show abstract

“…[24] TNF-α is known to induce neutrophil and endothelial cell activation. [25] Ce- rium nitrate [26] and N-acetylcysteine [27] was found to be effective in saving the zone of stasis by decreasing the level of TNF production.…”

Section: Discussionmentioning

confidence: 99%

Saving the zone of stasis in burns with melatonin: An experimental study in rats

Kayapınar

Seyhan

Avunduk

et al. 2015

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

Cerium nitrate treatment prevents progressive tissue necrosis in the zone of stasis following burn

Cited by 50 publications

References 27 publications

Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI)

Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI)

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Saving the zone of stasis in burns with melatonin: An experimental study in rats

Contact Info

Product

Resources

About