Cerium, gallium and zinc containing mesoporous bioactive glass coating deposited on titanium alloy

Shruti, S.; Andreatta, F.; Furlani, Erika; Marin, Elia; Maschio, S.; Fedrizzi, L.

doi:10.1016/j.apsusc.2016.03.209

Cited by 31 publications

(15 citation statements)

References 33 publications

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“…In our preliminary experiments, it was found that the heat treatment that was essential for the formation of mesoporous structure of MBG could lead to a detrimental interface reaction between the Ti-based substrate and MBG coating, thereby resulting in a destroyed microstructure of the MBG coating. In addition to the interface reaction, the difference in thermal expansion coefficient between the metal substrate and amorphous MBG coating might cause damage to the MBG coating during the heat treatment [ 27 ]. Therefore, in the present study, we designed and developed a SiO 2 interlayer as a transition layer to ensure that the MBG coating maintained its structure and composition—an approach that has been used between the substrate and functional coating of other materials [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Mesoporous Bioactive Glass Functionalized 3D Ti-6Al-4V Scaffolds with Improved Surface Bioactivity

Leeflang

et al. 2017

Materials

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Porous Ti-6Al-4V scaffolds fabricated by means of selective laser melting (SLM), having controllable geometrical features and preferable mechanical properties, have been developed as a class of biomaterials that hold promising potential for bone repair. However, the inherent bio-inertness of the Ti-6Al-4V alloy as the matrix of the scaffolds results in a lack in the ability to stimulate bone ingrowth and regeneration. The aim of the present study was to develop a bioactive coating on the struts of SLM Ti-6Al-4V scaffolds in order to add the desired surface osteogenesis ability. Mesoporous bioactive glasses (MBGs) coating was applied on the strut surfaces of the SLM Ti-6Al-4V scaffolds through spin coating, followed by a heat treatment. It was found that the coating could maintain the characteristic mesoporous structure and chemical composition of MBG, and establish good interfacial adhesion to the Ti-6Al-4V substrate. The compressive strength and pore interconnectivity of the scaffolds were not affected by the coating. Moreover, the results obtained from in vitro cell culture experiments demonstrated that the attachment, proliferation, and differentiation of human bone marrow stromal cells (hBMSCs) on the MBG-coated Ti-6Al-4V scaffolds were improved as compared with those on the conventional bioactive glass (BG)-coated Ti-6Al-4V scaffolds and bare-metal Ti-6Al-4V scaffolds. Our results demonstrated that the MBG coating by using the spinning coating method could be an effective approach to achieving enhanced surface biofunctionalization for SLM Ti-6Al-4V scaffolds.

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Section: Discussionmentioning

confidence: 99%

Mesoporous Bioactive Glass Functionalized 3D Ti-6Al-4V Scaffolds with Improved Surface Bioactivity

Leeflang

et al. 2017

Materials

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“…Although some studies have been carried out describing the effects of Ga 3+ on the structure of MBGs [39][40][41][42], as well as haemostatic and antibacterial effects [43] , from the best of our knowledge no study has considered the effects of Ga containing MBGs on bone cells, such as osteoblasts or osteoclasts. This is quite surprising considering the very interesting synergy between Ga 3+ and MBGs for the treatment of osteoporotic bone fractures.…”

Section: Introductionmentioning

confidence: 99%

The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses

et al. 2018

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Osteoporosis is the most prevalent bone disease affecting millions of patients every year. However, there is a lack of bone grafts specifically designed for the treatment of bone defects occurred because of osteoporotic fractures. The consequence is that osteoporotic bone defects are commonly treated with the same biomaterials intended for high quality bone tissue. In this work we have prepared mesoporous bioactive glasses doped with gallium, demonstrating osteoinductive capability by promoting the differentiation of pre-osteoblast toward osteoblasts and partial inhibition of osteoclastogenesis. Through a deep study of the local environment of gallium within the mesoporous matrix, this work shows that gallium release is not required to produce this effect on osteoblasts and osteoclasts. In this sense, the presence of this element at the surface of the mesoporous bioactive glasses would be enough to locally promote bone formation while reducing bone resorption.

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“…Silica-based mesoporous nanospheres have shown a great potential for drug loading–deloading and bioactive properties [ [139] , [140] , [141] , [142] , [143] ]. Incorporation of various metallic ions and their influence on the characteristics of mesoporous host glasses are well known [ [144] , [145] , [146] , [147] , [148] ]. Magnetic mesoporous glass scaffolds were prepared by Zhu et al.…”

Section: Structure–property Relationshipmentioning

confidence: 99%

Bioactive glasses and glass–ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives

Danewalia

2021

Materials Today Bio

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Bioactive glasses and glass-ceramics are well-proven potential biomaterials for bone-tissue engineering applications because of their compositional flexibility. Many research groups have been focused to explore the utility of bioactive glass–ceramics beyond bone engineering to hyperthermia treatment of cancer. Hyperthermia refers to raising the temperature of tumor close to 44°C at which malignant cells perish with negligible harm to normal cells. Hyperthermia can be employed by many means such as by ultrasonic waves, electromagnetic waves, infrared radiations, alternating magnetic fields, etc. Magnetic bioactive glass–ceramics are advantageous over other potential candidates for thermoseeds such as nanofluids, superparamagnetic nanoparticles because they can bond not only to the natural bone but also with soft tissues in few cases, which helps regenerating the affected part due to its bioactive nature. Strict restrictions on clinical settings ( < ) force the research activities to be more focused on material characteristics to raise the implant temperature to required ranges. Lots of efforts have been made in past years to tackle these challenges and design best-suited glass–ceramics for hyperthermia treatment. This review aims to provide essential information on the concept of hyperthermia treatment of cancer and recent developments in the field of bioactive glass–ceramics for cancer treatment. The advantages and disadvantages of magnetic glass–ceramics over other potential thermoseed materials are highlighted. In this field, the major challenges are to develop magnetic glasses, which have fast and bulk crystallization with optimized magnetic phases with lower Curie and Neel temperatures.

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Cerium, gallium and zinc containing mesoporous bioactive glass coating deposited on titanium alloy

Cited by 31 publications

References 33 publications

Mesoporous Bioactive Glass Functionalized 3D Ti-6Al-4V Scaffolds with Improved Surface Bioactivity

Mesoporous Bioactive Glass Functionalized 3D Ti-6Al-4V Scaffolds with Improved Surface Bioactivity

The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses

Bioactive glasses and glass–ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives

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