Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

Atkinson, Irina; Seciu-Grama, Ana Maria; Petrescu, Simona; Culiță, Daniela C.; Mocioiu, Oana Cătălina; Voicescu, Mariana; Mitran, Raul−Augustin; Lincu, Daniel; Prelipcean, Ana-Maria; Crăciunescu, Oana

doi:10.3390/pharmaceutics14061169

Cited by 18 publications

(11 citation statements)

References 52 publications

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“…Ce-containing MBG-derived 3D scaffolds were also successfully developed with drug delivery ability for possible use in tissue engineering applications [ 108 ]. These scaffolds were fabricated by using poly(methyl methacrylate) (PMMA) as a sacrificial template, and the presence of Ce was confirmed in both oxidation states Ce 4+ /Ce 3+ , in the scaffolds.…”

Section: Mesoporous Bioactive Glasses (Mbgs) As Platforms For the Del...mentioning

confidence: 99%

Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

et al. 2022

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Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.

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Section: Mesoporous Bioactive Glasses (Mbgs) As Platforms For the Del...mentioning

confidence: 99%

Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

et al. 2022

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“…When the glass is dissolved in the bodily fluid, these ions are slowly released and interact with cells, inducing changes in their metabolism. Various metal ions with antibacterial assets can be included into the glass network, such as copper (Cu + and Cu 2+ ) [ 56 , 57 ], zinc (Zn 2+ ) [ 58 , 59 ], gallium (Ga 3 + ) [ 60 , 61 ], cerium (Ce 3+ and Ce 4 + ) [ 62 , 63 ], silver (Ag + ) [ 64 , 65 , 66 , 67 ], and magnesium (Mg 2+ ) [ 68 ].…”

Section: Mechanism Of Antibacterial Action Of Metal Ionsmentioning

confidence: 99%

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Atkinson

2022

Bioengineering

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One of the major clinical issues during the implantation procedure is the bacterial infections linked to biofilms. Due to their tissue localization and the type of bacteria involved, bacterial infections at implant sites are usually difficult to treat, which increases patient morbidity and even mortality. The difficulty of treating biofilm-associated infections and the emergence of multidrug-resistant bacteria are further challenges for the scientific community to develop novel biomaterials with excellent biocompatibility and antibacterial properties. Given their ability to stimulate bone formation and have antibacterial properties, metal ion-doped bioactive glasses (BGs) have received considerable research. This mini review aims to be successful in presenting the developments made about the role of biocide metal ions incorporated into BGs against the development of bacterial biofilms and the spread of nosocomial diseases.

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“…Composite scaffolds are a positive replica of a porous template that is usually a foam based on polyurethane (PU) [ 7 ]. After several coatings with a bioactive glass paste or a sol–gel solution of a glass [ 8 ], the porous template matrix is burned while the bioactive glass is heated at a high temperature. The final 3D structures own a highly open and interconnected porous network that mimics the actual architecture of the cancellous bone [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration

et al. 2023

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Silica-based ceramics doped with calcium and magnesium have been proposed as suitable materials for scaffold fabrication. Akermanite (Ca2MgSi2O7) has attracted interest for bone regeneration due to its controllable biodegradation rate, improved mechanical properties, and high apatite-forming ability. Despite the profound advantages, ceramic scaffolds provide weak fracture resistance. The use of synthetic biopolymers such as poly(lactic-co-glycolic acid) (PLGA) as coating materials improves the mechanical performance of ceramic scaffolds and tailors their degradation rate. Moxifloxacin (MOX) is an antibiotic with antimicrobial activity against numerous aerobic and anaerobic bacteria. In this study, silica-based nanoparticles (NPs) enriched with calcium and magnesium, as well as copper and strontium ions that induce angiogenesis and osteogenesis, respectively, were incorporated into the PLGA coating. The aim was to produce composite akermanite/PLGA/NPs/MOX-loaded scaffolds through the foam replica technique combined with the sol–gel method to improve the overall effectiveness towards bone regeneration. The structural and physicochemical characterizations were evaluated. Their mechanical properties, apatite forming ability, degradation, pharmacokinetics, and hemocompatibility were also investigated. The addition of NPs improved the compressive strength, hemocompatibility, and in vitro degradation of the composite scaffolds, resulting in them keeping a 3D porous structure and a more prolonged release profile of MOX that makes them promising for bone regeneration applications.

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Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

Cited by 18 publications

References 52 publications

Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration

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