Ceria Nanozyme and Phosphate Prodrugs: Drug Synthesis through Enzyme Mimicry

Walther, Raoul; Huynh, Tin H.; Monge, Pere; Fruergaard, Anne Sofie; Mamakhel, Aref; Zelikin, Alexander N.

doi:10.1021/acsami.1c03890

Cited by 33 publications

(26 citation statements)

References 43 publications

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“…28,[34][35][36] On the other hand, ceria has a very high chemical affinity to phosphate species. [37][38][39] Upon interaction with phosphates, the redox cycling between Ce +3 /Ce +4 in nanoceria can be blocked, 40 preventing any potential positive cytoprotective effects of this material in cosmetic applications. Bearing in mind that organophosphates (e.g.…”

Section: Introductionmentioning

confidence: 99%

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

et al. 2022

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“…After confirming that the NO-generating activity was derived from the presence of cerium ions (Ce 3+ and Ce 4+ ) on the surface of ceria NPs, we further studied the internal roles of Ce 3+ and Ce 4+ on NO generation. The ratios of Ce 3+ /Ce 4+ were reported to be a decisive factor of different catalytic activities of ceria, including oxidase, [56] peroxidase, [69,70] superoxide dismutase, [64] catalase, [65] haloperoxidase, [71] phosphatase, [50] and glucuronidase. [72] We examined the ratio changes of Ce 3+ /Ce 4+ on the surface of ceria NPs before and after the interaction with GSNO by XPS.…”

Section: Catalytic Mechanismmentioning

confidence: 99%

“…The catalytic activity of ceria NPs is strongly influenced by the switching between the Ce 3+ and Ce 4+ oxidation states. [47][48][49][50] Due to the catalytic and the Ce 3+ /Ce 4+ switching nature of ceria NPs, it is reasonable to speculate the possibility of ceria NPs to induce NO release by acting as a catalyst to decompose NO donors, similar to gold, zinc oxide, and copper-based materials. To the best of our knowledge, ceria-mediated NO generation from S-nitrosothiols has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles as an Unexpected Catalyst to Generate Nitric Oxide from S‐Nitrosoglutathione

Luo

Zhou

Gao

et al. 2022

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half-life (<5 s) and diffusion distance (40-200 µm) in vitro and in vivo. [7] In addition, the biological functions of NO are pleiotropic and strongly dependent on its concentrations. At lower concentrations (pm to nm), NO promotes cell survival and proliferation, [8,9] while higher NO concentrations (µm to mm) cause cell apoptosis [10] with potential for anticancer, [11] antibacterial, [12] and antiviral applications. [13] To this end, researchers have developed a number of NO-releasing platforms where NO donors, denoted as substances that transport and release NO upon specific stimulus, are encapsulated into pre-fabricated scaffolds (e.g., silica nanoparticles, polymers, liposomes, hydrogels, and metal-organic frameworks). [8,[14][15][16][17] Even though these platforms have been demonstrated to enable controlled and sustained NO release profiles, [18][19][20] their NO payloads and duration of NO release principally rely on the finite amount of NO donors incorporated. To tackle this issue, NO delivery by catalytic approaches have been developed, which enables in situ continuous NO generation from naturally occurring endogenous NO donors S-nitrosothiols (RSNOs) mediated by catalytic reagents. [21] One of the well-known catalytic approaches for NO generation is the copper-facilitated decomposition of S-nitrosothiols, where transition Cu 2+ is reduced to Cu + by thiolate, and Cu + subsequently reacts with RSNO to release NO and regenerate Cu 2+ . [22] This discovery has led to the development of copper-based materials for NO release from S-nitrosoglutathione (GSNO), [23,24] S-nitrosocysteamine, [25,26] S-nitrosocysteine (CysNO), [27] and S-nitroso-Nacetyl-DL-penicillamine (SNAP). [28] Another representative catalytic agent for NO release is gold nanoparticles. Catalytic gold nanoparticles were reported to catalyze NO release from GSNO, SNAP, and S-nitrosopenicillamine, which was ascribed to the formation of Au-thiolate and the oxidation of Au 0 to Au [1] on the surface of gold nanoparticles. [29,30] Recently, Doverspike et al. [31] reported that zinc oxide particles enhanced NO release from GSNO, and our group [32,33] presented the ability of zinc oxide particles to catalytically decompose both endogenous (GSNO) and exogenous (β-gal-NONOate) donors to generate NO at physiological conditions. Intriguingly, the opposite capability, that is, NO-scavenging capability, of gold nanoparticles, [34] copper nanoparticles, [35] and zinc oxide particles [36,37] in the presence of excessive NO were also reported, which shows the multi-faceted functions of these transition metal nanoparticles.Ceria nanoparticles (NPs) are widely reported to scavenge nitric oxide (NO) radicals. This study reveals evidence that an opposite effect of ceria NPs exists, that is, to induce NO generation. Herein, S-nitrosoglutathione (GSNO), one of the most biologically abundant NO donors, is catalytically decomposed by ceria NPs to produce NO. Ceria NPs maintain a high NO release recovery rate and retain their crystalline structure for at least 4 w...

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“…The method was successfully applied to Abl and Src, the kinases that are involved in chronic myeloid leukemia [90]. Indeed, the ability of ceria to adsorb phosphate can be used to design phosphatasemimics and applied to the conversion of phosphate prodrugs into active therapeutics (Figure 9), including chemotherapeutics for advanced cancer therapy [91]. It also proved to be efficient in the dephosphorylation of thiamine pyrophosphate first to thiamine monophosphate, and then to thiamine, thus producing the free vitamin form [92].…”

Section: Phosphoproteomics and Phosphatase-like Nanozymesmentioning

confidence: 99%

“…Substrate scope of ceria nanozyme, in comparison with alkaline phosphatase, for the hydrolysis of organic phosphates in a study for the delivery of phosphate prodrugs. Reproduced with permission from [91], Copyright © 2021, American Chemical Society.…”

Section: Phosphoproteomics and Phosphatase-like Nanozymesmentioning

confidence: 99%

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

et al. 2021

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Ceria (CeO2) nanostructures are well-known in catalysis for energy and environmental preservation and remediation. Recently, they have also been gaining momentum for biological applications in virtue of their unique redox properties that make them antioxidant or pro-oxidant, depending on the experimental conditions and ceria nanomorphology. In particular, interest has grown in the use of biotemplates to exert control over ceria morphology and reactivity. However, only a handful of reports exist on the use of specific biomolecules to template ceria nucleation and growth into defined nanostructures. This review focusses on the latest advancements in the area of biomolecular templates for ceria nanostructures and existing opportunities for their (bio)applications.

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Ceria Nanozyme and Phosphate Prodrugs: Drug Synthesis through Enzyme Mimicry

Cited by 33 publications

References 43 publications

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

Ceria Nanoparticles as an Unexpected Catalyst to Generate Nitric Oxide from S‐Nitrosoglutathione

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

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