Cerebral sinovenous thrombosis in children: Clinical presentation and extension, localization and recanalization of thrombosis

Vieira, José Pedro; Luís, Catarina; Monteiro, José Paulo; Temudo, Teresa; Campos, Miguel; Quintas, Sofia; Nunes, Sofía

doi:10.1016/j.ejpn.2008.12.004

Cited by 61 publications

(44 citation statements)

References 21 publications

(53 reference statements)

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“…Yanı sıra trombosit-nötrofil etkileşimi lökositlerin adhezyon kapasitelerinde artışa yol açmakta ve her iki durum doku hasarının artışına neden olmaktadır (14). Periferal ven trombüsünde trombüsün yayılması muhtemelen kapaklar nedeniyle sınırlı kalırken dural sinüslerde kapak bulunmaması nedeniyle trombüsün yayılması sık görülmektedir ve bu durum prognoz üzerinde etkilidir (6,16). Kardiyovasküler hastalıklarda saptanan lökositozun sebep mi sonuç mu olduğu konusu tartışmalıdır.…”

Section: Discussionunclassified

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The prognostic value of increased leukocyte and neutrophil counts in the early phase of cerebral venous sinus thrombosis

Kamışlı¹,

Kamışlı²,

Gönüllü³

et al. 2012

Türk Beyin Damar Hast Derg

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Section: Discussionunclassified

“…Trombüsün oluşumunda, büyümesinde, organize olmasında veya rekanalize olmasında ise venöz staz, endoteliyal hasar, genetik ve kazanılmış protrombotik faktörler ve inflamasyon rol oynamaktadır (6). Bunların içinde bilhassa inflamasyonun önemi son yıllarda daha çok gündeme gelmiştir.…”

Section: Introductionunclassified

The prognostic value of increased leukocyte and neutrophil counts in the early phase of cerebral venous sinus thrombosis

Kamışlı¹,

Kamışlı²,

Gönüllü³

et al. 2012

Türk Beyin Damar Hast Derg

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“…A recent multi-center Portuguese study reported no influence of anticoagulation upon CSVT outcome 57. However, in a single center pediatric CSVT cohort, Mahendranath et.…”

Section: Therapymentioning

confidence: 94%

Cerebral Venous Thrombosis in the Mediterranean Area in Children

Menascu

Lotan²,

Zeev³

et al. 2011

Mediterr J Hematol Infect Dis

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Cerebral Venous Sinus (sinovenous) Thrombosis (CSVT) is a serious and rare disorder, increasingly recognized and diagnosed in pediatric patients. The etiology and pathophisiology has not yet been completely clarified, and unlike adults with CSVT, management in children and neonates remains controversial. However, morbidity and mortality are significant, highlighting the continued need for high-quality studies within this field. The following review will highlight aspects of CSVT in the mediteranian area in children.

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“…In the literature, prothombotic factors have been found with a rate of 24-64% in children in the post-neonatal period (1,2,8,(10)(11)(12). Conditions including head and neck traumas and infection (especially sinusitis, mastoiditis, meningitis) are in the first orders in the etiology (18,19,22). In our series, mastoiditis was observed in four patients.…”

Section: Discussionmentioning

confidence: 51%

“…6. and 12 th months in our patients. Although recanalization is a significant treatment objective in venous thrombosis, it has been reported to have no effect on the prognosis (22). Prophylactic anticoagulant treatment may be terminated in three months, if recanalization is observed in the early period (7).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cases with cerebral thrombosis in children

et al. 2016

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Aim: We aimed to evaluate the patients who were followed up in our clinic with a diagnosis of cerebral sinovenous thrombosis in terms of age, sex, clinical findings, etiology, thrombophilic factors, imaging findings, treatment and prognosis. Material and Methods:The files of 11 patients who were followed up in our pediatric neurology clinic with a diagnosis of cerebral thrombosis between 1 December 2010 and 31 December 2014 were retrospectively analyzed. Results:Seven of 11 patients were male (63.6%). The median age was 14 years (2-17 years). Six (54%) of the patients presented with a complaint of headache. Other complaints at presentation included diplopia (n:3), weakness and difficulty in speaking (n:1) and seizure (n:1). A diagnosis of pseudotumor cerebri was made in eight of the patients (72.7%). In the etiology, mastoiditis was found in three patients, mastoiditis and meningitis were found in combination in one patient, Behçet's disease was found in three patients and head trauma was found in one patient. In 3 patients, only prothrombotic genetic risk factors were present; one patient had deficiency of protein C and S, one patient had deficiency of antithrombin III and one patient had hyperhomosisteinemia in association with vitamin B12 deficiency. 1A homozygous MTFHR A1298C mutation was detected in the patient who had mastoiditis and meningitis and protein S deficiency and lupus anticoagulant were found in another patient who had mastoiditis. All patients received anticoagulant treatment and all patients recovered without neurological sequelae except one.Conclusions: Cerebral sinovenous thrombosis should be considered in patients who present with headache and focal neurological deficits. Appropriate utilization of imaging studies is necessary for the diagnosis. Detailed ear, nose and throat examination should be performed to detect mastoiditis. It is recommended that genetic risk factors should be investigated, because hereditary thrombophilis factors may have a role in children. Behçet's disease which is relatively common in our country should be considered in differential diagnosis. (Turk Pediatri Ars 2016; 51: 87-93)

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Cerebral sinovenous thrombosis in children: Clinical presentation and extension, localization and recanalization of thrombosis

Cited by 61 publications

References 21 publications

The prognostic value of increased leukocyte and neutrophil counts in the early phase of cerebral venous sinus thrombosis

The prognostic value of increased leukocyte and neutrophil counts in the early phase of cerebral venous sinus thrombosis

Cerebral Venous Thrombosis in the Mediterranean Area in Children

Evaluation of cases with cerebral thrombosis in children

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