Cerebral Venous Thrombosis in the Mediterranean Area in Children

Menascu, Shay; Lotan, Amit; Zeev, Ben; Gottl, U. Nowak; Kenet, Gili

doi:10.4084/mjhid.2011.029

Cited by 5 publications

(7 citation statements)

References 59 publications

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“…The diagnosis was made with brain MRI and MRV in all our patients. Although thrombosis in the sagittal sinus has been reported most frequently in the literature, thrombosis was found most commonly in the transverse and sigmoid sinuses in our series (13).…”

Section: Discussioncontrasting

confidence: 61%

“…The median age was 14 years (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Six of the patients (54.5%) presented with the complaint of headache.…”

Section: Resultsmentioning

confidence: 99%

“…There are no evidence-based recommendations for treatment of cerebral thrombosis in the pediatric age group because of lack of randomized controlled studies (13). The objective of antithrombotic treatment is to provide patency of the vascular bed and to prevent extension of thrombosis and formation of new thrombosis after acute treatment (13).…”

Section: Discussionmentioning

confidence: 99%

“…The objective of antithrombotic treatment is to provide patency of the vascular bed and to prevent extension of thrombosis and formation of new thrombosis after acute treatment (13). In the pediatric case series published in the last decade, antithrombotic agents used followTurk Pediatri Ars 2016; 51: 87-93 Ünver et al Cerebral thrombosis in children ing the diagnosis of cerebral thrombosis show variance (7).…”

Section: Discussionmentioning

confidence: 99%

“…Headache due to increased intracranial pressure (ICP) is the most common cause of presentation. Seizures, alterations in consciousness, encephalopathy, focal neurological findings (cranial nerve palsies, hemiparesis, sensory loss) may also be observed (7,13). Clinicians should be suspicious in any kind of acute neurological event and request necessary tests for making the diagnosis and adjusting treatment early.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of cases with cerebral thrombosis in children

et al. 2016

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Aim: We aimed to evaluate the patients who were followed up in our clinic with a diagnosis of cerebral sinovenous thrombosis in terms of age, sex, clinical findings, etiology, thrombophilic factors, imaging findings, treatment and prognosis. Material and Methods:The files of 11 patients who were followed up in our pediatric neurology clinic with a diagnosis of cerebral thrombosis between 1 December 2010 and 31 December 2014 were retrospectively analyzed. Results:Seven of 11 patients were male (63.6%). The median age was 14 years (2-17 years). Six (54%) of the patients presented with a complaint of headache. Other complaints at presentation included diplopia (n:3), weakness and difficulty in speaking (n:1) and seizure (n:1). A diagnosis of pseudotumor cerebri was made in eight of the patients (72.7%). In the etiology, mastoiditis was found in three patients, mastoiditis and meningitis were found in combination in one patient, Behçet's disease was found in three patients and head trauma was found in one patient. In 3 patients, only prothrombotic genetic risk factors were present; one patient had deficiency of protein C and S, one patient had deficiency of antithrombin III and one patient had hyperhomosisteinemia in association with vitamin B12 deficiency. 1A homozygous MTFHR A1298C mutation was detected in the patient who had mastoiditis and meningitis and protein S deficiency and lupus anticoagulant were found in another patient who had mastoiditis. All patients received anticoagulant treatment and all patients recovered without neurological sequelae except one.Conclusions: Cerebral sinovenous thrombosis should be considered in patients who present with headache and focal neurological deficits. Appropriate utilization of imaging studies is necessary for the diagnosis. Detailed ear, nose and throat examination should be performed to detect mastoiditis. It is recommended that genetic risk factors should be investigated, because hereditary thrombophilis factors may have a role in children. Behçet's disease which is relatively common in our country should be considered in differential diagnosis. (Turk Pediatri Ars 2016; 51: 87-93)

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Section: Discussioncontrasting

confidence: 61%

“…The median age was 14 years (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Six of the patients (54.5%) presented with the complaint of headache.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of cases with cerebral thrombosis in children

et al. 2016

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Zerebrovaskuläre Erkrankungen des Kindes- und Jugendalters

Hagel¹,

Panteliadis²,

von³

et al. 2014

Neuropädiatrie

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Trombosis de senos venosos cerebrales asociado a síndrome antifosfolípidos en un paciente pediátrico

Fonseca¹,

Schiller²

2015

Acta Neurol Colomb

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La trombosis de senos venosos cerebrales es un evento relativamente infrecuente en la población pediátrica. Su origen se ha asociado a múltiples condiciones y factores de riesgo como infecciones locales o sistémicas, malformaciones cardíacas, trauma, deshidratación, enfermedades crónicas y, en especial, a factores genéticos protrombóticos. La localización puede variar dependiendo de la etiología; además, puede cursar con una amplia variabilidad de signos y síntomas dependiendo de la edad del paciente. Se presenta el caso de un paciente masculino de 5 años, que desde los 2 años de edad presenta episodios de cefalea y ataxia de forma intermitente, con autorresolución. Posterior a un evento presenta crisis tónico-clónica del hemicuerpo derecho, seguida de un estado epiléptico súper refractario. En la neuroimagenes (RNM-angioresonancia) se evidencia trombosis de senos venosos cerebrales asociada a un accidente cerebrovascular isquémico en el globus pallidus, el mesencéfalo y los hemisferios cerebelosos. El paciente presenta el anticuerpo anticardiolipina IgM y es positivo para anticoagulante lúpico. Hematología y reumatología pediátrica confirman el diagnóstico de trombosis de senos venosos cerebrales secundario a síndrome antifosfolípidos. El paciente logra mejoría clínica con la implementación de inmunoterapia más anticoagulación.

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Cerebral Venous Thrombosis in the Mediterranean Area in Children

Cited by 5 publications

References 59 publications

Evaluation of cases with cerebral thrombosis in children

Evaluation of cases with cerebral thrombosis in children

Zerebrovaskuläre Erkrankungen des Kindes- und Jugendalters

Trombosis de senos venosos cerebrales asociado a síndrome antifosfolípidos en un paciente pediátrico

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