Cerebral mucormycosis ? A case report

Rao, V. R. K.; Pillai, S M Shanmugham; Mathews, G.; Radhakrishnan, V. V.

doi:10.1007/bf00342923

Cited by 13 publications

(4 citation statements)

References 3 publications

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“…Meanwhile, cerebral angiography showed occlusion in the left posterior cerebral artery and hemorrhagic infarction lesions in the bilateral medial temporal lobe. Collectively, the diagnosis was finally adjusted to fungal cerebral (Rao et al 1978a). A systematic review of the fungal cerebral vasculitis was retrieved from Web of Science Core Collection, and up to May 28th, 2021, 20 papers had been published in total (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Infection-derived vasculitis is caused by angiogenic pathogens, including Aspergillus sp., Candida albicans, zygomycotina sp., Cryptococcus neoformans, and so on, and their etiopathogenesis can be summarized as follows: subarachnoidal meningitis, sinuses or orbital infection, and immune mechanism in the context of chronic infections (Lampros et al 2021;Herlin et al 2015;Thirunavukkarasu et al 2021). Early recognition and diagnosis of cerebral vasculitis can, to a great extent, alleviate the risk of its severity and improve prognosis (Rao et al 1978a;Jung et al 2018;Salvarani et al 2007;Sasaki et al 2010;Ellis et al 2018).…”

Section: Discussionmentioning

confidence: 99%

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Cerebral vasculitis caused by Talaromyces marneffei and Aspergillus niger in a HIV-positive patient: a case report and literature review

Gao

Chen

et al. 2022

J. Neurovirol.

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Cerebral vasculitis is a long-standing but flourishing and fadeless research topic. Infections are a frequent cause of cerebral vasculitis, vital to diagnose due to involvement of specific anti-infection treatments. A 65-year-old man visited the hospital for his neurological symptoms without obvious inducements. After admission, radiological examination and comprehensive conventional microbiological tests (CMTs) revealed suspected intracranial infectious vasculitis. Metagenomic next-generation sequencing (mNGS) and reverse transcription-polymerase chain reaction further confirmed that his cerebral vasculitis was caused by Talaromyces marneffei (T. marneffei) and Aspergillus niger (A. niger) co-infection. The patient’s final diagnosis changed from initial herpetic encephalitis, due to the past history of cephalosome and facial herpes and non-significant antiviral therapeutic effects, to fungal cerebral vasculitis. The patient was discharged after use of targeted antifungal therapies on day 18 of his admission, and his associated symptoms disappeared completely at follow-up 3 weeks later. We first illustrated the presence of uncommon cerebral vasculitis caused by T. marneffei and A. niger in a human immunodeficiency virus-positive patient. In clinically suspected patients with infectious cerebral vasculitis, mNGS should be performed to detect potential pathogens if CMTs may not provide useful pathogenic clues, highlighting the importance of mNGS in the diagnosis and treatment of infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cerebral vasculitis caused by Talaromyces marneffei and Aspergillus niger in a HIV-positive patient: a case report and literature review

Gao

Chen

et al. 2022

J. Neurovirol.

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“…All cases of patients with no predisposing factors (diabetes mellitus; immune suppression; intravenous drug abuse; iron overload or deferoxamine treatment; s/p trauma recently in the same area of mucormycosis infection) : Cases included were those with acute mucormycosis infection in the rhinocerebral region diagnosed by histology with or without a positive culture, when no known predisposing conditions for rhinocerebral mucormycosis were reported and data regarding outcome were available. Our search yielded a total of 73 cases including the present case [2,3,6–42] (Table 1).…”

Section: Case Reportmentioning

confidence: 99%

Rhinocerebral mucormycosis in patients without predisposing medical conditions: a review of the literature

Elinav

Zimhony

Cohen

et al. 2009

Clinical Microbiology and Infection

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Rhinocerebral mucormycosis is a rare disease, affecting almost exclusively patients with known predisposing conditions such as diabetes mellitus, immunocompromised status, haemochromatosis or major trauma. Subsequent to a case of rhinocerebral mucormycosis in a 78-year-old woman without any known risk factor, we reviewed the published English-language literature and found an additional 72 cases. Reviewing all the published case series of mucormycosis involving any site, the proportion of apparently normal hosts among cases of rhinocerebral mucormycosis was found to be 9.06% (95% confidence interval 6.7-11.8). These findings suggest that rhinocerebral mucormycosis in patients without known predisposing factors is more prevalent than was previously believed.

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“…Only a few cases of successfully treated primary mucor cerebral abscess have been reported. [1][2][3][4][5] Such abscesses are often associated with diabetes mellitus, intravenous drug misuse, craniofacial infections, or immunosuppression,6 with immunocompromised patients having an especially increased risk of opportunistic infections. Up to now, implanted reservoirs have been used to ensure high concentrations of antibiotics in CSF.…”

mentioning

confidence: 99%

Local application of antimycotics in mucormycosis cerebri: a case report.

Mohsenipour

Schirmer

Frank

et al. 1996

Journal of Neurology, Neurosurgery & Psychiatry

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A 65 year old man was found to have mucormycosis cerebri during immunosuppression after treatment of hairy cell leukaemia with 2-chlorodeoxyadenosine. Although mucormycosis cerebri has a poor prognosis, the patient survived after systemic administration of high dose amphotericin B, extensive excision of the abscess, and additional local application of amphotericin B with the help of an absorbable gelatin sponge.

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Cerebral mucormycosis ? A case report

Abstract: A case of cerebral fungal granuloma with histological evidence of vasculitis is reported and the literature briefly reviewed. The value of surgery and chemotherapy for this entity which cured the patient without any sequelae of the disease process or chemotherapeutic agent is emphasized.

Cited by 13 publications

References 3 publications

Cerebral vasculitis caused by Talaromyces marneffei and Aspergillus niger in a HIV-positive patient: a case report and literature review

Cerebral vasculitis caused by Talaromyces marneffei and Aspergillus niger in a HIV-positive patient: a case report and literature review

Rhinocerebral mucormycosis in patients without predisposing medical conditions: a review of the literature

Local application of antimycotics in mucormycosis cerebri: a case report.

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