Cerebral hemangioma with glial neoplasia (angioglioma?)

Abstract

Two patients are reported who had intracerebral mass lesions composed of hemangioma and glial neoplasm. After excision, one recurred as an oligodendroglioma, and the remnant of the other remained static over a 5-year period. These lesions may represent a subgroup of cerebral hemangiomas that have the biological potential for future glial neoplastic growth. Reference is made to experimental work with polyoma virus which can induce cavernous hemangiomas in the central nervous system in mice, and which is a papovavirus. Other papovaviruses can induce ependymomas in hamsters.

Association between cavernous angioma and cerebral glioma. Report of two cases and literature review of so-called angiogliomas

“…Some authors 1,5,6,11,20,21 expressed different etiological hypothesis including: genetical predisposition 20 ; reactive or malformative nature 1,6,21 ; viral origin 5 ; and exceptional …”

“…Fisher in 1982 5 , reporting two cases of cavernous angioma associated with an oligodendroglioma and a pylocitic astrocytoma respectively, considered a viral cause as a possible pathogenesis. Indeed, cavernomas can be induced experimentally in rats after inoculation of Polyoma virus, while the neoplasm can be induced directly after inoculation of SV40 virus of the Papova family.…”

Association between cavernous angioma and cerebral glioma: Report of two cases and literature review of so-called angiogliomas

“…Some authors 1,5,6,11,20,21 expressed different etiological hypothesis including: genetical predisposition 20 ; reactive or malformative nature 1,6,21 ; viral origin 5 ; and exceptional . White et al 20 , sustained the hypothesis of a genetical predisposition of these mixed tumors after reporting the autopsy of a 45 year-old male patient with cerebral, lung and hepatic cavernomas deceased after surgery for a septum pellucidum astrocytoma.…”

Associação de malformação vascular e gliomas: estudo de quatro casos

“…Em uma revisão recente, Kasantikul e col. 9 relataram 10 casos e revisaram 31 casos da associação de MAV com glioma. A maioria dos casos 1,6,8,[10][11][12][13][14] tem ocorrência simultânea ou coexistente das lesões, no mesmo local ou eventualmente em diferentes lobos ou hemisférios. Entretanto, há descrições do desenvolvimento de um tumor no mesmo sítio de uma MV diagnosticada meses ou até anos antes 5,12 .…”

“…A maioria dos casos 1,6,8,[10][11][12][13][14] tem ocorrência simultânea ou coexistente das lesões, no mesmo local ou eventualmente em diferentes lobos ou hemisférios. Entretanto, há descrições do desenvolvimento de um tumor no mesmo sítio de uma MV diagnosticada meses ou até anos antes 5,12 . Em alguns casos, os exames de imagem pré-operatórios já sugerem o diagnóstico de MAV 7,13,14 .…”