Association between cavernous angioma and cerebral glioma. Report of two cases and literature review of so-called angiogliomas

Abstract

SummaryThe association between vascular malformations and cerebral gliomas is unusual. While the association between cavernous angioma with gliomatous lesions is even more rare, it is considered by certain authors to be a particular pathological entity termed angioglioma. The authors report on two cases of association of a cavernous angioma with a ganglioglioma and an oligodendroglioma respectively. Subsequent review of the literature on the so-called angiogliomas was conducted. In the author's opinion, the entity of angiogliomas represents a general spectrum of angiomatous neoplasms that include gliomatous tumors, in the majority low-grade gliomas, associated with a major vascular component. KEY WORDS. Brain tumor. Glioma. Cavernous angioma. AngiogliomaAsociación entre angioma cavernoso y glioma cerebral. Reporte de dos casos y revisión de la literatura acerca de los llamados angiogliomas Resumen La asociación entre las malformaciones vasculares y los gliomas cerebrales es inusual. Mientras que la asociación entre angioma cavernoso con lesiones gliomatosas es aún más rara, es por esto considerado por algunos autores como una entidad patológica particular llamada angioglioma.Los autores reportan dos casos de asociación de un angioma cavernoso con una ganglioglioma y un oligodendroglioma, respectivamente. Además se realizó una revisión de la literatura sobre los llamados angiogliomas.En opinión de los autores, la entidad de los angiogliomas se presenta dentro de un espectro general de neoplasias angiomatosas, que incluyen tumores cerebrales, en su mayoría gliomas de bajo grado, asociados a su vez, con un componente vascular importante.

Congenital glioblastoma coexisting with vascular developmental anomaly

“…In adults, the primary brain tumours may be accompanied by vascular malformations [27] and such rare coincidence involves mostly gliomas and meningiomas [10,11]. The pathogenetic suggestions consider such angiogliomatic lesions as a result of reactive astroglial neoplastic proliferation second ary to the preexisting vascular malformation.…”

Original article The coexistence of pleomorphic xanthoastrocytoma and arteriovenous malformation. A

“…The primary brain tumours may be accompanied by vascular malformations and such rare coincidence involves mostly gliomas and meningiomas [2,4,13,16,19,20,23,24,29].…”

“…The lesions, consisting of mixed tumours of glial and vascular origin, particularly of cavernous or arteriovenous type, have been often defined as angiogliomas [3,13,19,25,30,41]. The term "angioglioma" is confusing and according to some authors should not be used to determine the true coincidence of vascular and neoplastic glial lesions.…”

“…Vas cular malformations might be associated with different glial components including benign and anaplas tic astrocytoma, oligodendroglioma, mixed oligo-astrocytoma or glioblastoma [4,13,15,16,18,20,35,45]. The majority of vascular pathology in coexistence with gliomas consists of arteriovenous malformation (AVM), less often cavernous angioma.…”

“…Most frequently the lesion consists of mixed elements of glial and vascular origin and is determined as angiogliomas [13,19,25,30,41]. The coexistence of vascular malformation with PXA is extremely rare, especially in the context of these two patterns occurring within the same tumour mass.…”