Cerebral cysticercosis: Clinical and pathological observations with emphasis on the encephalitic type

Srinivas, HV; Rao, T. Vasudev; Dv, Deshpande

doi:10.1016/0303-8467(80)90036-0

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…10,17,34,35 The angiogenesis observed in the brain tissue of infected rats has also been reported in human and porcine NCC. 12,13,36 The angiogenesis process probably plays a role in promoting and regulating other biological events, such as inflammation, fibroblast proliferation, extracellular matrix synthesis, and BBB disruption, which have all been reported in others studies.…”

Section: Neurocysticercosis Rat Modelmentioning

confidence: 87%

Novel Rat Model for Neurocysticercosis Using Taenia solium

Verástegui

Mejia

Clark

et al. 2015

The American Journal of Pathology

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Neurocysticercosis is caused by Taenia solium infecting the central nervous system and is the leading cause of acquired epilepsy and convulsive conditions worldwide. Research into the pathophysiology of the disease and appropriate treatment is hindered by lack of cost-effective and physiologically similar animal models. We generated a novel rat neurocysticercosis model using intracranial infection with activated T. solium oncospheres. Holtzman rats were infected in two separate groups: the first group was inoculated extraparenchymally and the second intraparenchymally, with different doses of activated oncospheres. The groups were evaluated at three different ages. Histologic examination of the tissue surrounding T. solium cysticerci was performed. Results indicate that generally infected rats developed cysticerci in the brain tissue after 4 months, and the cysticerci were observed in the parenchymal, ventricle, or submeningeal brain tissue. The route of infection did not have a statistically significant effect on the proportion of rats that developed cysticerci, and there was no dependence on infection dose. However, rat age was crucial to the success of the infection. Epilepsy was observed in 9% of rats with neurocysticercosis. In histologic examination, a layer of collagen tissue, inflammatory infiltrate cells, perivascular infiltrate, angiogenesis, spongy change, and mass effect were observed in the tissue surrounding the cysts. This study presents a suitable animal model for the study of human neurocysticercosis.

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Section: Neurocysticercosis Rat Modelmentioning

confidence: 87%

Novel Rat Model for Neurocysticercosis Using Taenia solium

Verástegui

Mejia

Clark

et al. 2015

The American Journal of Pathology

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“…Cerebellum and brainstem had the lesions least frequently. Recemose type large grape like multi lobulated cysts were seen in the subarachnoid space in the Sylvian fissures and basal cisterns as the cysts can grow unhindered by the parenchymal tissue resistance as has been observed by Srinivas et al [22].…”

Section: Discussionmentioning

confidence: 55%

“…This is mainly related to the topographic location, the numerical density and the host immune reaction to the cestode larval parasite. The host response and the resultant brain parenchymal changes, in tum are dependant on the morphological viability of the cysts [22].…”

Section: Discussionmentioning

confidence: 99%

“…The co-existence of cerebral cysticercosis has been found to enhance the morbidity and mortality due to JE [22,25]. Sabin et al [26] first suggested helminths as a possible intermediate host for the dissemination of the virus of the brain .…”

Section: Discussionmentioning

confidence: 99%

“…In the cases reported by Ahuja et al [24] there was no case resembling the encephalitic form of cerebral cysticercosis. Srinivas et al [22] described 5 cases and gave a detailed morphological description of changes which were distinct from those seen in a typical case of JE. In the present study also, we had 6 cases showing similar features of encephalitic picture, in the absence of serological evidence for JE.…”

Section: Discussionmentioning

confidence: 99%

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Neurocysticercosis – A Clinicopathological Appraisal

Kudesia

Santosh

Pal

et al. 1998

Medical Journal Armed Forces India

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Neurocysticercosis is the most common parasitic disease affecting the human central nervous system, with protean clinical manifestations. During the last 17 years, 153 cases of neurocysticercosis were histopathologically diagnosed on surgically resected and autopsied material. Variable number of cysts, from a solitary one to multiple were found invading different parts of the neuraxis (118 cases). These cestode larval forms had a prediliction for locating in the cerebral grey matter (98 cases), followed by subcortical nuclear area (12), cerebral ventricles and subarachnoid cisterns (26 cases). Patients harbouring parenchymal cysts manifested predominantly with seizures and encephalitis (113 cases) whereas those with ventricular and/or cisternal cysts presented with features of chronic meningitis and hydrocephalus. The unusual clinical presentations were psychiatric symptoms with behavioural abnormalities and stroke in the young as a result of cysticercal meningitis with associated arteritis. Primary cysticercal abscess in the brain parenchyma was an interesting pathological feature noted in 3 cases. In the endemic areas, the co-existence of neurocysticercosis appears to enhance the morbidity and mortality due to Japanese encephalitis (31 cases) . The surface glycoprotein of the cysticercal cyst has been identified to be the antigenic component to which the host immune system responds by forming antibody in the CSF. MJAFI 1998; 54: 13-18

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Cystic lesions of the brain. A classification based on pathogenesis, with consideration of histological and radiological features

Hew

Kamman

et al. 1993

European Journal of Radiology

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Cerebral cysticercosis: Clinical and pathological observations with emphasis on the encephalitic type

Cited by 5 publications

References 8 publications

Novel Rat Model for Neurocysticercosis Using Taenia solium

Novel Rat Model for Neurocysticercosis Using Taenia solium

Neurocysticercosis – A Clinicopathological Appraisal

Cystic lesions of the brain. A classification based on pathogenesis, with consideration of histological and radiological features

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